Control of regular structure and functionalization of oligomers of bicyclic beta-proline derivative
| Project/Area Number |
23790006
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
OTANI Yuko 東京大学, 大学院・薬学系研究科, 助教 (60451853)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | オリゴマー / シス-トランス異性化 / NMR / 三級アミド / 分子動力学計算 / 規則 構造 / 二環性骨格 / 分子の架橋化 / シスートランス異性化 / 規則構造 / βｰアミノ酸 / ヘリックス / チオアミド / 非天然アミノ酸 |
|---|
| Research Abstract |
Methods for synthesis of conformationally constrained β-proline mimics, that is, bridgehead-substituted7-azabicyclo[2.2.1]heptane-2-endo-carboxylic acids was established. The oligomers take ordered structure with trans-amide bonds in solution. And cis-trans equilibrium of the cis-amide-type bicyclic dimer substituted at the bridgehead position is controlled dynamically by cross-linking reaction.
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Report
(3 results)
Research Products
(54 results)
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[Journal Article] Attenuated desensitization of b-adrenergic receptor by water-soluble N-nitrosamines that induce S-nitrosylation without NO release2013
Author(s)
Noriko Makita*, Yoji Kabasawa*, Yuko Otani, Firman, Junichiro Sato, Makiko Hashimoto, Michio Nakaya, Hiroaki Nishihara, Masaomi Nangaku, Hitoshi Kurose, Tomohiko Ohwada, Taroh Iiri
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Journal Title
Circ. Res
Volume: 112
Issue: 2
Pages: 327-334
DOI
Related Report
Peer Reviewed
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[Journal Article] GPR34 is a receptor for lysophosphatidylserine with a fatty acid at the sn-2 position2012
Author(s)
Kitamura H, Makide K, Shuto A, Ikubo M, Inoue A, Suzuki K, Sato Y, Nakamura S, Otani Y, Ohwada T, Aoki J
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Journal Title
J Biochem
Volume: 151
Issue: 5
Pages: 511-518
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Development of a vaccinia H1-related (VHR) phosphatase inhibitor with a nonacidic phosphate-mimicking core structure2011
Author(s)
Hirai, G., Tsuchiya, A., Koyama, Y., Otani, Y., Oonuma, K., Dodo, K., Simizu, S., Osada, H. & Sodeoka, M
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Journal Title
ChemMedChem
Volume: 6
Issue: 4
Pages: 617-622
DOI
Related Report
Peer Reviewed
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