Regiocontrol of heteroaryne reactions by redox change
| Project/Area Number |
23790017
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
IKAWA Takashi 静岡県立大学, 薬学部, 助教 (20453061)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | ピリダイン / イソキノリン / Diels-Alder 反応 / 位置選択性 / ケイ素官能基 / フラン / 複素環 / カップリング / Diels-Alder反応 / アライン / アライン前駆体 / シリル基 / スタニル基 / ヘテロ環合成 / フッ素アニオン |
|---|
| Research Abstract |
A new synthetic route to isoquinoline derivatives consisting regioselective Diels-Alder reactions of 3,4-pyridynes with furans and following functional group transformations is reported. The key for the regioselectivity of the cycloaddition reactions is electropositive silicon atom of the 2-position of 3,4-pyridyne. This directing group can also be substituted with various functional groups.
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Report
(3 results)
Research Products
(44 results)
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[Journal Article] Generation of 3-Borylbenzynes, Their Regioselective Diels-Alder Reactions, and Theoretical Analysis2013
Author(s)
Takashi Ikawa, Akira Takagi, Yurio Kurita, Kozumo Saito, Kenji Azechi, Masahiro Egi, Yuji Itoh, Hiroaki Tkiwa, Yasuyuki Kita, and Shuji Akai
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Journal Title
Tetrahedron
Volume: 69
Issue: 21
Pages: 4338-4352
DOI
Related Report
Peer Reviewed
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