Synthesis and application of asterolaurins having anti-cancer activity
Project/Area Number |
23790018
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Multi-year Fund |
Research Field |
Chemical pharmacy
|
Research Institution | Tohoku Pharmaceutical University |
Principal Investigator |
|
Project Period (FY) |
2011-04-28 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
Keywords | 抗がん活性物質 / 抗HIV活性物質 / アステロラウリン類 / キセニカン骨格 / 環拡大反応 / アステロラウリン / トシル化 / ワンポット環化 / コンホマー / 抗がん活性 / 全合成 / 生物活性相関研究 |
Outline of Final Research Achievements |
Synthesis of the xenialactol-methylacetal core and the unsaturated fatty acid side chain of 9-deoxyxenialactol C (asterolaurins analogue) were achieved. The synthetic method involved the following key step: i) [1,3]-sigmatropic rearrangement, ii) isomerization of nitrile and iii) acid-induced domino deprotection/lactol cyclization/methylacetalization in one step.
|
Report
(5 results)
Research Products
(21 results)