Design and Evaluation of Stable Hydrophilic Fullerene C60 Nanoparticlesas Next Generation Photoserlsitizer in Photodyrlamic Therapy
Project/Area Number |
23790062
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Physical pharmacy
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Research Institution | Sojo University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
|
Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | フラーレン / シクロデキストリン / がん光線力学療法 / 活性酸素種 / ナノ粒子 / 光増感剤 / フラーレンC60 / 2-ヒドロキシプロピル-β-シクロデキストリン / 光線力学療法 / 活性酸素 |
Research Abstract |
Fullerene C60 has been appealing as an efficient photosensitizer in photodynamictherapy.The objective of this study is to prepare C60 nanoparticles via 2-hydroxypropy1一β一cyclodextrin,which is clinically used as a safe solubilizing agent for several preparations.We elucidated its nanostructure,physical properties and biological activities.
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Report
(3 results)
Research Products
(17 results)