Conformational change of X11L and its physiological functions
| Project/Area Number |
23790069
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
SAITO Yuhki 北海道大学, 大学院・薬学研究院, 助教 (70548180)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | アルツハイマー病 / X11L / リン酸化 / APP / X１１ / Alzheimer's Disease / Aβ / X11s |
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| Research Abstract |
The purpose of this research is to reveal the mechanism of AD pathogenesis. X11-like (X11L) protein has been identified as a suppressor of AD pathogenesis. We revealed in this project that the conformational change of X11L was correlated to the amount of Aβ generation and that its conformational change was regulated by the phosphorylation of calboxyl-terminal of X11L protein. Moreover, we identified a few candidate kinases of X11L protein.
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Report
(3 results)
Research Products
(35 results)
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[Presentation] Involvement of X11/X11L in Alzheimer's-related beta-amyloid generation and epileptogenesis2012
Author(s)
Kanada, Y., Saito, Y., Nishimura, M., Kimura, N. and Suzuki T
Organizer
Alzheimer's Association International Conference 2012
Place of Presentation
Vancourver Convention Center, Vancouver, British Columbia, Canada
Related Report
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[Presentation] Membrane microdomain localization of APP C-terminal fragments regulated by the phosphorylation at cytoplasmic Thr668 residue2012
Author(s)
Matsushima, T., Saito, Y., Nishimura, M., Kimura, N., Hata, S. and Suzuki T
Organizer
Alzheimer's Association International Conference 2012
Place of Presentation
Vancourver Convention Center, Vancouver, British Columbia, Canada
Related Report
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[Presentation] Identification of a gene which controls abeta accumulation using APP Tg mice with mixed genetic background splicing variant specific effect of kinesin light chain 1 (KLC1)2011
Author(s)
Mikiko Yokokoji, Morihara Takeshi, Noriyuki Hayashi, Masayasu Okochi, Toshiharu Suzuki, Yuhki Saito, Nobuyuki Kimura, Masatoshi Takeda, Hiroaki Kazui, Hiroyasu Akatsu, Akitaka Takamura, Taiichi Katayama, Naohiro Ito, Shinichi Tatsumi, Kiyoko Kato, Kanta Yanagida, Takashi Kodama, Shinji Tagami, Norihisa Tanaka, Takashi Kudo, Takashi Morihara
Organizer
Alzheimer's Association International Conference 2011, Paris Porte de Versailles Convention and Exhibition Center
Place of Presentation
Paris, France
Year and Date
2011-07-17
Related Report
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