Roles of SYD-1 and SYD-2 proteins and neuronal trafficking in presynaptic formation

• Project/Area Number: 23790070
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Biological pharmacy
• Research Institution: Hokkaido University
• Principal Investigator: TARU Hidenori 北海道大学, 創成研究機構, 特任助教 (30533731)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 神経生物学 / 神経科学 / 脳・神経 / 薬学 / 遺伝学 / シナプス / シナプス形成

Research Abstract

Neuronal synapses are cell adhesion structures, which are fundamental units for functions of neuronal system. In nematode C.elegans, SYD (SYnapse Defective) -1 and SYD-2 have been identified as central regulators of presynaptic formation. Based on a large scale modifier screen and genetic analysis, we proposed a possibility that presynaptic components are precisely assembled by SYD-1/SYD-2 pathway under negative regulation involving a cadherin-like cell-adhesion molecule.

Research Products

• [Journal Article] Mechanism of intramembrane cleavage of Alcadeins by γ-secretase (2013)
  • Author(s): Piao, Y., Kimura, A., Urano, S., Saito, Y., Taru, H., Yamamoto, T., Hata, S. and Suzuki, T
  • Journal Title: PLoS One Volume: 8 Issue: 4 Pages: e62431-e62431
  • DOI: 10.1371/journal.pone.0062431
  • Peer Reviewed
• [Journal Article] The Liprin homology domain is essential for the homomeric interaction of SYD-2/Liprin-α protein in presynaptic assembly (2011)
  • Author(s): Hidenori Taru and Yishi Jin
  • Journal Title: J. Neuroscience Volume: 31 Issue: 45 Pages: 16261-16268
  • DOI: 10.1523/jneurosci.0002-11.2011
  • NAID: 120004043727
  • Peer Reviewed
• [Journal Article] Intracellular trafficking of the amyloid β-protein precursor (APP) regulated by novel function of X11-like (2011)
  • Author(s): Saito Y
  • Journal Title: PLoS One Volume: 6 Issue: 7 Pages: e22108-e22108
  • DOI: 10.1371/journal.pone.0022108
  • Peer Reviewed
• [Presentation] Identification of a cell adhesion molecule involved in negative regulation of presynaptic assembly in C.elegans (2013)
  • Author(s): Hidenori Taru
  • Organizer: Experimental Biology 2013
  • Place of Presentation: ボストン国際会議場(USA)
  • Year and Date: 2013-04-22
• [Presentation] 線虫(C.elegans)DDニューロンのプレシナプス除去に関わる遺伝子の探索 (2012)
  • Author(s): 星野裕子、多留偉功
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2012-12-15
• [Presentation] Identification of mutants involved in SYD-1-mediated presynaptic assembly in C.elegans (2012)
  • Author(s): Hidenori Taru
  • Organizer: 8th FENS Forum of Neuroscience
  • Place of Presentation: バルセロナ国際会議場(スペイン)
  • Year and Date: 2012-07-15
• [Presentation] The Liprin Homology Domain is Essential for the Homomeric Interaction of SYD-2/Liprin-alpha Protein in Presynaptic Assembly (2011)
  • Author(s): Hidenori Taru and Yishi Jin
  • Organizer: The American Society for Cell Biology, Annual Meeting
  • Place of Presentation: デンバー国際会議場(USA)
  • Year and Date: 2011-12-04
• [Presentation] Essential Role of a Conserved Homophilic Interaction Domain of SYD-2/Liprin-alpha Protein in Presynaptic Assembly in C.elegans (2011)
  • Author(s): Hidenori Taru
  • Organizer: The American Society for Cell Biology 2011 Annual Meeting
  • Place of Presentation: the Colorado Convention Center, Denver, Colorado, USA
• [Presentation] Identification of mutants involved in SYD-1-mediated presynaptic assembly in C.elegans
  • Author(s): Hidenori Taru
  • Organizer: 8th FENS Forum of Neuroscience
  • Place of Presentation: バルセロナ国際会議場（スペイン）
• [Presentation] 線虫 (C.elegans) DDニューロンのプレシナプス除去に関わる遺伝子の探索
  • Author(s): 星野 裕子
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場(福岡県）
• [Presentation] Identification of a cell adhesion molecule involved in negative regulation of presynaptic assembly in C.elegans
  • Author(s): Hidenori Taru
  • Organizer: EXPERIMENTAL BIOLOGY 2013
  • Place of Presentation: ボストン国際会議場（USA)
• [Remarks]
  • URL: http://www.cris.hokudai.ac.jp/taru/