| Project/Area Number |
23790115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Biological pharmacy
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
MAKINO Asami 独立行政法人理化学研究所, 小林脂質生物学研究室, 特別研究員 (20373368)
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 脂質ラフト / コレステロール / スフィンゴミエリン / インフルエンザ / ラフト / ニーマンピックＣ型 / ウイルス感染 |
|---|
| Research Abstract |
Lipid rafts are plasma membrane lipid domains enriched in sphingolipids and cholesterol. The size, composition and function of lipid rafts are matters of debate partially because of the lack of an appropriate probe to visualize them in situ. We identified a novel, non-toxic mushroom protein that specifically binds a complex of sphingomyelin (SM), a major sphingolipid in mammalian cells, and cholesterol. The purified protein, termed Nakanori, labeled cell surface domains in SM and cholesterol-dependent manner.
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