Structure-activity relationship of atpenin A5 derivatives as complex II selective inhibitors
| Project/Area Number |
23790140
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Drug development chemistry
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| Research Institution | Kitasato University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 構造活性相関 / complex II / 天然有機化合物 / 創薬化学 |
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| Research Abstract |
Structure-activity relationship of atpenin A5 focused on 2-position and substituents of the side chain has been achieved. On this study, the importance of stereochemistry and the presence of each methyl and chloro groups on the side chain were elucidated.
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Report
(3 results)
Research Products
(15 results)
