Development of test for central nervous system developmental toxicity using in vitro organization from human pluripotent stem cells.

Research Project

Project/Area Number	23790150
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Environmental pharmacy
Research Institution	Tokyo Medical University (2012) The University of Tokyo (2011)
Principal Investigator	IMANISHI Satoshi 東京医科大学, 医学部, ポストドクター (50462479)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000) Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords	発生毒性 / 多能性幹細胞 / 中枢神経毒性 / 毒性評価 / 神経毒性
Research Abstract	The most important point is the regulation of uniformity of differentiation in establishment the test developmental toxicity using pluripotent stem cells. In this study, the timing and efficiency of nervous differentiation from mouse ES cell were successfully made uniform. The central nervous system developmental toxicityof chemical can be detected in the system. Additionally, shortening of period for neural differentiation was achieved by the modification of culture condition of human ES cells.

Report

(3 results)