Approach to a new target for pancreatic cancer therapy to elevate the response of anti-cancer drugs

• Project/Area Number: 23790198
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Keio University
• Principal Investigator: NISHI Koji 慶應義塾大学, 医学部, 特任講師 (00398249)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: オーダーメイド医療 / ゲムシタビン / メタボローム / 核酸代謝 / EMT / 膵癌

Research Abstract

Metabolomics analysis using human pancreatic cancer cell lines showed that CTP synthase was involved in the action of gemcitabine. In addition, gemcitabine was observed to be involved in the sensitivity to these cancer cell lines. Epithelial - mesenchymal

Research Products

• [Presentation] Title: A metabolomic analysis revealed the involvement of deoxycytidine kinase and CTP synthase in the sensitivity of human pancreatic cancer cells to gemcitabine (2012)
  • Author(s): Koji Nishi, Yurika Fujimura, Akito Nishimuta, Masahiro Sugimoto, Tomoyoshi Soga, Yusuke Tanigawara
  • Organizer: American Association of Cancer Research, Annual meeting2012
  • Place of Presentation: Chicago, USA
  • Year and Date: 2012-03-31
• [Presentation] A metabolomic analysis revealed the involvement of deoxycytidine kinase and CTP synthase in the sensitivity of human pancreatic cancer cells to gemcitabine (2012)
  • Author(s): 西 弘二
  • Organizer: American Association of Cancer Research Annual Meething
  • Place of Presentation: Chicago, USA
• [Presentation] 演題「ゲムシタビン曝露ヒト膵癌細胞の網羅的メタボローム解析」 (2011)
  • Author(s): 西弘二、藤村由梨香、西牟田章戸、杉本昌宏、曽我朋泰、谷川原祐介
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
  • Year and Date: 2011-10-03
• [Presentation] ゲムシタビン曝露ヒト膵癌細胞の網羅的メタボローム解析
  • Author(s): 西弘二、藤村由梨香、西牟田章戸、杉本昌弘、曽我朋義、谷川原祐介
  • Organizer: 日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場（愛知）
• [Presentation] A metabolomic analysis revealed the involvement of deoxycytidine kinase and CTP synthase in the sensitivity of human pancreatic cancer cells to gemcitabine
  • Author(s): 西弘二、藤村由梨香、西牟田章戸、杉本昌弘、曽我朋義、谷川原祐介
  • Organizer: American Association of Cancer Research Annual Meeting 2012
  • Place of Presentation: McCormick Place West (シカゴ、アメリカ)