Role of oxidative stress-responsive miRNA on the variation of expression and function of protein regulating pharmacokinetics
| Project/Area Number |
23790206
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Mie University (2013)
Kinjo Gakuin University (2011-2012) |
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Principal Investigator |
IKEMURA Kenji 三重大学, 医学部附属病院, 助教 (70513935)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | マイクロRNA / P-糖タンパク質 / 薬物体内動態 / 小腸上皮細胞 / 転写後調節 / P－糖蛋白質 / 肝虚血再灌流障害 / 酸化ストレス / 薬物代謝酵素 / タイトジャンクション / P-糖蛋白質 / P-glycoprotein |
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| Research Abstract |
We found that microRNA-145 (miR-145) regulates the expression and function of P-glycoprotein (P-gp) in the small intestine. This result provide new insight into the post-transcriptional regulation of intestinal P-gp. Moreover, miRNAs regulate the expression and function of proteins regulating pharmacokinetics in intestinal epithelial cells. Therefore, miRNAs could be significant factors affecting inter- and intra-individual variations in the pharmacokinetics and intestinal absorption of drugs.
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Report
(4 results)
Research Products
(23 results)
