Determination of differential UGT expression in brain region and prediction of drug interaction via UGT

• Project/Area Number: 23790207
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Medical pharmacy
• Research Institution: Meijo University
• Principal Investigator: KATOH Miki 名城大学, 薬学部, 准教授 (70345594)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 脳 / グルクロン酸抱合 / UGT1a / mRNA / 誘導 / UGT1A / ｍRNA / タンパク質

Research Abstract

All UGT1A isoforms and UGT1A enzyme activities were detected in 9 regions of the rat brain. We showed that phenobarbital treatment induced UGT1A1, UGT1A6, and UGT1A7 mRNA expression and enzyme activities in some regions of the rat brain.

Research Products

• [Presentation] フェノバルビタールによる脳内解毒酵素の発現変動-UDP-グルクロン酸転移酵素の変動- (2012)
  • Author(s): 榊原有季子、加藤美紀、近藤裕也、灘井雅行
  • Organizer: フォーラム2012:衛生薬学・環境トキシコロジー
  • Place of Presentation: 名古屋
  • Year and Date: 2012-10-26
• [Presentation] Effects of Phenobarbital Treatment on UDP-glucuronosyltransferase 1A Subfamily in Rat Brain (2012)
  • Author(s): Yukiko Sakakibara, Miki Katoh, Yuya Kondo and Masayuki Nadai
  • Organizer: 19th Microsomes and DrugOxidations (MDO) and 12th European International Society for the Study of Xenobiotics (ISSX) meeting
  • Place of Presentation: Noordwijk aan Zee, Netherlands
  • Year and Date: 2012-06-18
• [Presentation] フェノバルビタールのよるラット脳内UDP-グルクロン酸転移酵素1aサブファミリーの誘導に関する研究 (2012)
  • Author(s): 榊原有季子、加藤美紀、近藤裕也、灘井雅行
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 札幌
  • Year and Date: 2012-03-30
• [Presentation] Effects of Phenobarbital Treatment on UDP-glucuronosyltransferase 1A Subfamily in Rat Brain. (2012)
  • Author(s): Yukiko Sakakibara, Miki Katoh, Yuya Kondo and Masayuki Nadai
  • Organizer: 19th Microsomes and Drug Oxidations (MDO) and 12th European International Society for the Study of Xenobiotics(ISSX) meeting
  • Place of Presentation: Noordwijk aan Zee, Netherlands
• [Presentation] フェノバルビタールによる脳内解毒酵素の発現変動 -UDP-グルクロン酸転移酵素の変動- (2012)
  • Author(s): 榊原有季子、加藤美紀、近藤裕也、灘井雅行
  • Organizer: フォーラム2012：衛生薬学・環境トキシコロジー（名古屋）
  • Place of Presentation: 名古屋