Understanding of mechanisms underlying the expression changes of the therapeutic targets identified by quantitative proteomic analysis in renal cell carcinomas
| Project/Area Number |
23790209
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
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| Research Institution | Himeji Dokkyo University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 腎癌 / VHL / 低酸素 |
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| Research Abstract |
Previously, we detected the differences in protein expression between cancerous and noncancerous tissues of human renal cell carcinomas (RCC) by quantitative proteomic analysis, and identified many RCC-related proteins. Among them, the expression changes of the isozymes of phosphofructokinase and one of RNA-binding proteins were dependent on VHL status and were also found under hypoxic conditions in human renal and colorectal cancer cell lines. Those of these proteins under hypoxia occurred with or without their changes at mRNA level. Meanwhile, there were differences in the plasma concentrations of some RCC-related proteins between RCC patients and healthy controls, suggesting their use might represent a useful tool for primary detection of RCC.
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Report
(4 results)
Research Products
(44 results)
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[Journal Article] Potential tumor markers of renal cell carcinoma : α-Enolase for postoperative follow up, and galectin-1 and galectin-3 for primary detection2013
Author(s)
N. Kaneko, A. Gotoh, N. Okamura, E. Matsuo, S. Terao, M. Watanabe, Y. Yamada, G. Hamami, T. Nakamura, M. Ikekita, K. Okumura, O. Nishimura
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Journal Title
Int J Urol
Volume: 20
Pages: 530-5
Related Report
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[Journal Article] TNF-α -857C>T genotype is predictive of clinical response after treatment with definitive 5-fluorouracil/cisplatin-based chemoradiotherapy in Japanese patients with esophageal squamous cell carcinoma.2013
Author(s)
H. Omatsu, A. Kuwahara, M. Yamamori, M. Fujita, T. Okuno, I. Miki, T. Tamura, K. Nishiguchi, N. Okamura, T. Nakamura, T. Azuma, T. Hirano, K. Ozawa, M. Hirai.
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Journal Title
Int J Med Sci.
Volume: 10
Issue: 12
Pages: 1755-1760
DOI
Related Report
Peer Reviewed
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[Journal Article] THRB genetic polymorphisms can predict severe myelotoxicity after definitive chemoradiotherapy in patients with esophageal squamous cell carcinoma.2012
Author(s)
Miki I, Nakamra T, Kuwahara A, Ymamori M, Nishiguchi, Tamura T, Okuno T, Omatsu H, Mizuno S, Hirai M, Azuma T, Sakaeda T.
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Journal Title
Int. J. Med. Sci.
Volume: 9(9)
Issue: 9
Pages: 748-56
DOI
Related Report
Peer Reviewed
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