The role of FGF signaling in genital development: for understanding the mechanisms underlying hypospadias.
| Project/Area Number |
23790229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General anatomy (including Histology/Embryology)
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
HARADA Masayo 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (80555756)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
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| Keywords | 外生殖器 / FGF / 尿道 / 尿道下裂 |
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| Research Abstract |
The goal of this research is to understand the developmental mechanisms of external genitalia in which congenital malformations such as hypospadias occur at a high frequency. The roles of FGF signaling during the external genitalia outgrowth and urethral tubulogenesis were investigated using genetically modified mice. This research demonstrated that 1)mesenchymal FGF signaling is required for the GT outgrowth, 2)Ectodermal FGF signaling is required for urethral tube formation,3)Endodermal FGF signaling contributes to stratification of urethral epithelium. These findings will contribute to the understanding of the molecular mechanisms of hypospadias.
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Report
(3 results)
Research Products
(6 results)
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[Presentation] FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion to mediate joint development2012
Author(s)
Harada M, Murakami H, Okawa A, Okimoto N, Hiraoka S, Nakahara T, Akasaka R, Siraishi Y, Futatsugi N, Mizutani-Koseki Y, Kuroiwa A, Shirouzu M, Yokoyama S, Taiji M, Iseki S, Ornitz DM, Koseki H, Nimura A, Yamaguchi K, Akita K.
Organizer
Hong Kong Society for Developmental Biology Symposium From Embryology to Disease Mechanisms
Place of Presentation
Hong Kong
Related Report
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[Presentation] FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion to mediate joint development2011
Author(s)
Harada M, Murakami H, Okawara A, Okimoto N, Hiraoka S, Nakahara T, Akasaka R, Shiraishi Y, Futatsugi N, Kuroiwa A, Yokoyma S, Taiji M, Iseki S, Ornitz DM, Yamaguchi K, Akita K, Koseki H.
Organizer
Molecular Genetics
Place of Presentation
Hinxton, Cambridge, UK
Related Report
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[Presentation] FGF9 monomer-dimer equilibrium regulates extracellular matrix affinity and tissue diffusion to mediate joint development2011
Author(s)
Harada M, Murakami H, Okawar A, Okimoto N, Hiraoka S, Nakahara T, Akasaka R, Shiraishi Y, Futatsugi N, Kuroiwa A, Yokoyma S, Taiji M, Iseki S, Ornitz DM, Yamaguchi K, Akita K, Koseki H
Organizer
Molecular Genetics 20th - 23rd Sep 2011
Place of Presentation
Wellcome Trust Conference Centre, Hinxton, Cambridge, UK
Related Report
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