The molecular basis of the Blood-Brain Barrier

• Project/Area Number: 23790236
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: General anatomy (including Histology/Embryology)
• Research Institution: Keio University
• Principal Investigator: KANDA Hiroshi 慶應義塾大学, 医学部, 助教 (60508597)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 血液脳関門 / BBB / ショウジョウバエ / 遺伝学 / グリア / スクリーニング / RNAi

Research Abstract

In order to address the molecular mechanismsfor regulating the integrity of Blood-Brain Barrier (BBB), we have utilized the Drosophila melanogaster, fruit fly, as a model system. We have performed an RNAi-based screen to identify genes that are involved i

Research Products

• [Journal Article] The Drosophila ortholog of MLL 3/MLL 4, trithorax related, functions as a negative regulator of tissue growth (2013)
  • Author(s): Kanda H, Nguyen A, Chen L, Okano H and Hariharan I
  • Journal Title: Mol. Cell Biol. Volume: 33 Pages: 1702-1710
  • Peer Reviewed
• [Journal Article] Conserved metabolic energy production pathways govern Eiger/TNF-induced nonapoptotic cell death (2011)
  • Author(s): Kanda H, Igaki T, Okano H, Miura M.
  • Journal Title: Proc Natl Acad Sci U S A. Volume: 108 Pages: 18977-82
  • Peer Reviewed
• [Journal Article] Conserved metabolic energy production pathways govern Eiger/TNF-induced non-apoptotic cell death (2011)
  • Author(s): Kanda, H., Igaki, T., Okano, H., and Miura, M.
  • Journal Title: Proc. Natl. Acad. Sci. USA Volume: 108 Issue: 47 Pages: 18977-18982
  • DOI: 10.1073/pnas.1103242108
  • Peer Reviewed
• [Presentation] Identification of genes required for the integrity of Blood-Brain Barrier in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: Neuro-Vascular Wiring Symposium 2012:ポスター発表
  • Place of Presentation: 奈良県新公会堂(奈良)
• [Presentation] A genetic approach for the organization and function of the Blood-Brain Barrier in Drosophila (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: The 4th Biennial Symposium on Brain and Mind Research in the Asia-Pacific (BMAP 2012):ポスター発表
  • Place of Presentation: 慶應義塾大学三田キャンパス(東京)
• [Presentation] MLL family proteins differently regulate cell growth and proliferation in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Alexander Nguyen, Hideyuki Okano and Iswar Hariharan.
  • Organizer: 第35回日本分子生物学会年会:ポスター発表
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡(福岡)
• [Presentation] RNAi-based genetic screen of genes required for the integrity of Blood-Brain Barrier in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: 第10回日本ショウジョウバエ研究会、口頭発表
  • Place of Presentation: 東京慈恵会医科大学(東京)
• [Presentation] MLL family proteins differently regulate cell growth and proliferation in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Alexander Nguyen, Hideyuki Okano and Iswar Hariharan.
  • Organizer: 35回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Presentation] Identification of genes required for the integrity of Blood-Brain Barrier in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano.
  • Organizer: Neuro-Vascular Wiring Symposium 2012
  • Place of Presentation: 奈良
• [Presentation] RNAi-based genetic screen of genes required for the integrity of Blood-Brain Barrier in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano.
  • Organizer: 第１０回日本ショウジョウバエ研究会
  • Place of Presentation: 東京
• [Presentation] A genetic approach for the organization and function of the Blood-Brain Barrier in Drosophila. (2012)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano.
  • Organizer: The 4th Biennial Symposium on Brain and Mind Research in the Asia-Pacific (BMAP2012)
  • Place of Presentation: 東京
• [Presentation] A Genetic Approach for the Organization and Function of the Blood-Brain Barrier in Drosophila (2011)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano.
  • Organizer: The 1st Asia Pacific Drosophila Research Conference:ポスター発表
  • Place of Presentation: Chientan Youth Activity Center(台湾・台北)
• [Presentation] Conserved metabolic energy production pathways govern Eiger/TNF-induced non-apoptotic cell death (2011)
  • Author(s): Hiroshi Kanda, Tatsuhi Igaki, Hideyuki Okano, and Masayuki Miura
  • Organizer: 第34回日本分子生物学会年会:ポスター発表
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] Molecular Basis of the integrity of Blood-Brain Barrier in Drosophila (2011)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: 第34回日本神経科学大会、口頭発表
  • Place of Presentation: パシフィコ横浜(横浜)
• [Presentation] A Genetic Approach for the Organization and Function of the Blood-Brain Barrier in Drosophila. (2011)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: 1st Asia Pacific Drosophila Research Conference
  • Place of Presentation: 台北（台湾）
• [Presentation] Molecular basis of the integrity of Blood-Brain Barrier in Drosophila. (2011)
  • Author(s): Hiroshi Kanda, Rieko Shimamura, and Hideyuki Okano
  • Organizer: 第34回日本神経科学大会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Presentation] Conserved metabolic energy production pathways govern Ei ger/TNF-induced non-apoptotic cell death. (2011)
  • Author(s): Hiroshi Kanda, Tatsushi Igaki, Hideyuki Okano, and Masayuki Miura.
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: パシフィコ横浜（神奈川県）
• [Remarks] 慶應義塾大学 医学部 生理学教室
  • URL: http://www.okano-lab.com/
• [Remarks]
  • URL: http://www.okano-lab.com/