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Molecular mechanism of mineral transport related to cellular reactive oxygen species level

Research Project

Project/Area Number 23790264
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General physiology
Research InstitutionKanazawa University

Principal Investigator

KIKUCHI Akihiro  金沢大学, 医学系, 博士研究員 (90321752)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords活性酸素 / ミネラル / トランスポーター / X線吸収スペクトル / タンパク質結晶構造解析 / X線吸収スペクトル
Research Abstract

A fine-tuned balance between production and scavenging of reactive oxygen species (ROS) is crucial for living cells. Since minerals (essential trace elements) can be a factorin regulation of ROS level, mechanisms of mineral transport at molecular level are essential for understanding the tuning mechanism of the ROS level in living cells. In this study, techniques for analysis of local structure around mineral using X-ray absorption spectroscopy has been established. Also, micro crystals of selenoprotein P, a selenium transporter, have been obtained. Further crystallographic study will be contributed the finding of scavenging mechanism of ROS by selenium-sites in the protein.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (3 results)

All 2012

All Journal Article (1 results) (of which Peer Reviewed: 1 results) Book (2 results)

  • [Journal Article] Creation of a Binuclear Purple Copper Site within a de Novo Coiled-Coil Protein2012

    • Author(s)
      D. Shiga, Y. Funahashi, H. Masuda, A. Kikuchi, M. Noda, S. Uchiyama, K. Fukui, K. Kanaori, K. Tajima, Y. Takano, H. Nakamura, M. Kamei, T. Tanaka
    • Journal Title

      Biochemistry

      Volume: 51 Issue: 40 Pages: 7901-7907

    • DOI

      10.1021/bi3007884

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Book] 金属錯体の機器分析(下)2012

    • Author(s)
      大塩 寛紀(編著)、菊地 晶裕(共著)
    • Publisher
      三共出版
    • Related Report
      2012 Final Research Report
  • [Book] 金属錯体の機器分析(下)2012

    • Author(s)
      大塩寛紀(編著)、菊地晶裕(共著)
    • Total Pages
      398
    • Publisher
      三共出版
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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