To reveal a cause of development of hypertension with long term measurement of sympathetic nerve activity

• Project/Area Number: 23790285
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology (including Physical medicine and Nutritional physiology)
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: YOSHIMOTO Misa 独立行政法人国立循環器病研究センター, 研究所, 研究員 (20418784)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 高血圧 / 神経性動脈圧調節 / 腎交感神経活動 / 腰部交感神経活動 / ラット / 交感神経 / 腰部交感神経 / 動脈圧

Research Abstract

Hypertension is a disease. One in four adults in the world have been diagnosed with high blood pressure. The aim of the present study was to explore a potential role of sympathetic nerve activity in the initial development of hypertension. The aim of the present study was to explore a potential role of sympathetic nerve activity in the initial development of hypertension. Salt sensitive hypersensitive rats and stroke-prone spontaneously hypertensive rats were used this experiments. The rats were chronically instrumented with a bipolar electrode for measurements of renal (RSNA) and lumbar sympathetic nerve activity (LSNA) and telemeter for measurements of arterial pressure (AP) and heart rate (HR). RSNA and LSNA apparently did not increase while development of hypertension occurred. It is therefor likely that possible contribution of sympathetic nerve activity to the initial development of hypertension in those hypersensitive rats remains uncertain.

Research Products

• [Journal Article] Role of cardiac sympathetic nerves in blood pressure regulation (2014)
  • Author(s): Erica A. Wehrwein, Misa Yoshimoto, Pilar Guzman, Amit Shah, David L. Kreulen and John W. Osborn
  • Journal Title: Autonomic Neuroscience Volume: S1566-0702(14) Pages: 35-41
  • DOI: 10.1016/j.autneu.2014.02.005
  • Peer Reviewed
• [Journal Article] Sympathetic nerve activity during sleep, exercise, and mental stress (2013)
  • Author(s): Miki, K., Yoshimoto, M.
  • Journal Title: Autonomic Neuroscience Volume: 174 Pages: 15-20
  • Peer Reviewed
• [Journal Article] Shifts in the baroreflex control of sympathetic nerve activity induced by exercise (2013)
  • Author(s): Miki, K., Yoshimoto, M.
  • Journal Title: J Phys Fitness Sports Med Volume: 2 Pages: 319-324
  • NAID: 10031179354
  • Peer Reviewed
• [Journal Article] The Serotonin Pathway-A Therapeutic Target For Pulmonary Hypertension? Assessing Vascular Function Using Synchrotoron Radiation Microangiography. (2013)
  • Author(s): Gray EA, Tsuchimochi H, Pearson JT, Sonobe T, Fujii Y, Yoshimoto M, Umetani K, Shirai M, Schwenke DO.
  • Journal Title: J Synchrotron Radiat Volume: 20(5) Issue: 5 Pages: 756-764
  • DOI: 10.1107/s0909049513021213
  • Peer Reviewed
• [Journal Article] Acute Rho-kinase inhibition improves coronary dysfunction in vivo, in th e early diabetic microcirculation. (2013)
  • Author(s): Pearson JT, Jenkins Mi. Edgley AJ, Sonobe T, Joshi M. Waddingham MT, Fujii V. Schwenkc DO, Tsuchi mochi H. Yoshimoto M, Umetani K, Kelly DJ, Shirai M.
  • Journal Title: Cardiovasc Diabetol Volume: 12 Issue: 1 Pages: 111-124
  • DOI: 10.1186/1475-2840-12-111
  • Peer Reviewed
• [Journal Article] Sympathetic nerve activity during sleep, exercise, and mental stress. (2013)
  • Author(s): Miki, K. and Yoshimoto, M
  • Journal Title: Autonomic Neuroscience Volume: 174 Issue: 1-2 Pages: 15-20
  • DOI: 10.1016/j.autneu.2012.12.007
  • Peer Reviewed
• [Journal Article] Functional Role of Diverse Changes in Sympathetic Nerve Activity in Regulating Arterial Pressure during REM Sleep (2011)
  • Author(s): Yoshimoto, M., Yoshida, I.,and Miki, K.
  • Journal Title: Sleep Volume: 011, 34(8) Pages: 1093-1101
  • Peer Reviewed
• [Journal Article] Functional Role of Diverse Changes in Sympathetic Nerve Activity in Regulating Arterial Pressure during REM Sleep (2011)
  • Author(s): Yoshimoto, M., Yoshida, I., and Miki, K
  • Journal Title: Sleep Volume: 011, 34(8) Issue: 8 Pages: 1093-1101
  • DOI: 10.5665/sleep.1168
  • Peer Reviewed
• [Journal Article] Imaging of the closed-chest mouse pulmonary circulation using synchrotron radiation microangiography (2011)
  • Author(s): Sonobe T, Schwenke DO, Pearson JT, Yoshimoto M, Fujii Y, Umetani K, Shirai M
  • Journal Title: J Appl Physiol Volume: 111 Issue: 1 Pages: 75-80
  • DOI: 10.1152/japplphysiol.00205.2011
  • Peer Reviewed
• [Presentation] Responses of renal and lumbar sympathetic nerve activity to chronic intermittent hypoxia in conscious rats (2014)
  • Author(s): 吉本光佐
  • Organizer: 第91回日本生理学会大会
  • Place of Presentation: 鹿児島大学郡元キャンパス
• [Presentation] Changes in renal sympathetic nerve activity during development of renovascularhypertensive ratshypertension in spontaneously hypertensive rats (2013)
  • Author(s): Misa Yoshimoto, Kenju Miki, Shirai Mikiyasu
  • Organizer: 90^<th> Annual Metting of the Physiological Society of Japan
  • Place of Presentation: Tokyo
  • Year and Date: 2013-03-28
• [Presentation] Sympathetic nerve activity during the development of hypertension in Dahl salt-sensitive rats (2013)
  • Author(s): M. Yoshimoto, N. Mineyama, M. Shirai1, K. Miki
  • Organizer: 37th Congress of IUPS
  • Place of Presentation: Birmingham, UK
• [Presentation] Time course of changes in sympathetic nerve activity during development of hypertension in spontaneously hypertensive rats (2013)
  • Author(s): Naoko Mineyama, Misa Yoshimoto, Mikiyasu Shirai and Kenju Miki
  • Organizer: Experimental Biology
  • Place of Presentation: Boston, USA(The FASEB Journal. 2013;27:1108.4)
• [Presentation] Sympathetic nerve activity and systemic arterial pressure during obstructive sleep apnea in conscious rats (2013)
  • Author(s): Chie Sukeguchi and Kenju Miki
  • Organizer: Experimental Biology
  • Place of Presentation: Boston, USA(The FASEB Journal. 2013;27:1117.5)
• [Presentation] Chronic effects of obstructive apnea on renal and lumbar sympathetic nerve activity in conscious rats (857.3) (2013)
  • Author(s): Kenju Miki, Chie Sukeguchi, and Misa Yoshimoto
  • Organizer: Experimental Biology
  • Place of Presentation: San Diego, USA(FASEB J April 2014 28:857.3)
• [Presentation] Time course of changes in sympathetic nerve activity and heart rate during development of hypertension in spontaneously hypertensive rats (2013)
  • Author(s): Naoko Mineyama, Misa Yoshimoto, Hiroko Awazu, Yumi Onishi, Asuka Shimazu, Mikiyasu Shirai, Kenju Miki
  • Organizer: 90^<th> Annual Metting of the Physiological Society of Japan
  • Place of Presentation: Tokyo
• [Presentation] Sympathetic nerve activity during the development of hypertension in Dahl salt-sensitive rats (2013)
  • Author(s): Misa Yoshimoto, Naoko MIneyama, Mikiyasu Shirai, Kenju MIki
  • Organizer: International Congress ofPhysiological Sciences
  • Place of Presentation: Birmingham UK
• [Presentation] Time course of changes in sympathetic nerve activity and heart rate during development of hypertension in spontaneously hypertensive rats (2013)
  • Author(s): Naoko Mineyama, Misa Yoshimoto, Yuko Onishi, Mikiyasu Sirai, Kenju Miki
  • Organizer: 第90回日本生理学会大会
  • Place of Presentation: タワーホール船堀、東京
• [Presentation] Sympathetic nerve activity during the development of hypertension in Dahl salt-sensitive rats (2013)
  • Author(s): Misa Yoshimoto, Mikiyasu Sirai, Kenju Miki
  • Organizer: IUPS 2013 (International Union of Physiological Sciences)
  • Place of Presentation: Birmingham, UK
• [Presentation] 高血圧発症に果たす交感神経活動の役割ー動物実験による検証 (2012)
  • Author(s): 吉本光佐
  • Organizer: 第65回日本自律神経学会総会
  • Place of Presentation: 都市センターホテル
  • Invited
• [Presentation] Long term measurement of renal sympathetic nerve activity and arterial pressure in two_kidney and one_clip hypertensive rats (2012)
  • Author(s): Misa Yoshimoto, Takashi Sonobe, Yutaka Fujii, Kenju Miki, Mikiyasu Shirai
  • Organizer: 第89回日本生理学会
  • Place of Presentation: 松本
• [Presentation] Changes in sympathetic nerve activity during initial development of hypertension in Dahl Salt Sensitive rats (2012)
  • Author(s): Naoko Mineyama, Misa Yoshimoto, Yuko Onishi, Mikiyasu Sirai, Kenju Miki
  • Organizer: 第89回日本生理学会
  • Place of Presentation: 松本
• [Presentation] Sympathetic nerve activity in rats with hypertension induced by a highsalt diet and angiotensin administration (2012)
  • Author(s): Misa Yoshimoto, Kenju Miki, Mikiyasu Shirai, John W. Osborn
  • Organizer: 第89回日本生理学会 （学会賞受賞発表）
  • Place of Presentation: 松本
• [Book] Cardiac-renal neural reflex operates as a primary negative feedback loop for maintaining body fluid homeostasis. In : The neural and hormonal regulation of kidney function (2012)
  • Author(s): Miki, K., Yoshimoto, M.( ed by J. Coote, H. M. Snow)
  • Publisher: Shaker Verla, Germany
• [Book] Cardiac-renal neural reflex operates as a primary negative feedback loop for maintaining body fluid homeostasis (2012)
  • Author(s): Kenju Miki and Misa Yoshimoto
  • Total Pages: 147
  • Publisher: Sharker Verlag, Aachen, Germany