Role of tissue-type plasminogen activator and matrix metalloproteinase in dementia
Project/Area Number |
23790289
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
NAGAI Nobuo 長浜バイオ大学, アニマルバイオサイエンス学科, 教授 (90260281)
YAMAKAWA Kasumi 浜松医科大学, 医学部附属病院, 薬剤師 (70563287)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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Keywords | 組織型プラスミノゲン活性化因子 / 血液脳関門透過性 / 組織型プラスミノーゲン活性化因子 / マトリックスメタロプロテアーゼ |
Outline of Final Research Achievements |
We studied on vascular dementia by using mice with deficient of tissue-type plasminogen activator (t-PA). t-PA bound to a receptor of lipid metabolism, activated the endothelial cells, induced the vascular endothelial growth factor, changed the defense function of brain, induced and activated catabolic enzymes to cerebral cells by the synergistic action with reactive oxygen species induced by cell death. Endogenous t-PA may contribute to potential escape response and modulation of motivation in vascular dementia.
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Report
(5 results)
Research Products
(6 results)
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[Journal Article] Urokinase-type plasminogen activator and plasminogen mediate activation of macrophage phagocytosis during liver repair in vivo.2012
Author(s)
Kawao N, Nagai N, Tamura Y, Horiuchi Y, Okumoto K, Okada K, Suzuki Y, Umemura K, Yano M, Ueshima S, Kaji H, Matsuo O.
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Journal Title
Thromb Haemost
Volume: 107
Issue: 04
Pages: 749-59
DOI
Related Report
Peer Reviewed
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