2014 Fiscal Year Final Research Report
Role of tissue-type plasminogen activator and matrix metalloproteinase in dementia
Project/Area Number |
23790289
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
General pharmacology
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Research Institution | Hamamatsu University School of Medicine |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
NAGAI Nobuo 長浜バイオ大学, アニマルバイオサイエンス学科, 教授 (90260281)
YAMAKAWA Kasumi 浜松医科大学, 医学部附属病院, 薬剤師 (70563287)
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Project Period (FY) |
2011-04-28 – 2015-03-31
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Keywords | 組織型プラスミノゲン活性化因子 |
Outline of Final Research Achievements |
We studied on vascular dementia by using mice with deficient of tissue-type plasminogen activator (t-PA). t-PA bound to a receptor of lipid metabolism, activated the endothelial cells, induced the vascular endothelial growth factor, changed the defense function of brain, induced and activated catabolic enzymes to cerebral cells by the synergistic action with reactive oxygen species induced by cell death. Endogenous t-PA may contribute to potential escape response and modulation of motivation in vascular dementia.
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Free Research Field |
中枢神経薬理
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