olecular mechanisms of protein transport through photoreceptor cilia in light/dark adaptation
| Project/Area Number |
23790348
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General medical chemistry
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| Research Institution | Osaka University (2012)
Osaka Bioscience Institute (2011) |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 網膜 / 視細胞 / 繊毛 / IFT / ゼブラフィッシュ |
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| Research Abstract |
We found that diversity of functional relationships between vertebrate ciliary kinesin motors, and our data shows that the repertoire of kinesin motors changes in some cilia during their differentiation. We also identified ectopic accumulation of transducin in the retinal outer nuclear layer of Mak deficient mice, suggesting the possibility that involvement of Mak in the molecular mechanism of transducin transport through cilia between the photoreceptor outer segments and inner segments.
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Report
(3 results)
Research Products
(19 results)
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[Journal Article] Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina2011
Author(s)
Omori, Y., Katoh, K., Sato, S., Muranishi, Y., Chaya, T., Onishi, A.(代表), Minami, T., Fujikado, T., Furukawa, T.
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Journal Title
PLoS One
Volume: 6(5)
Issue: 5
Pages: e19685-e19685
DOI
Related Report
Peer Reviewed
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