• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

olecular mechanisms of protein transport through photoreceptor cilia in light/dark adaptation

Research Project

Project/Area Number 23790348
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field General medical chemistry
Research InstitutionOsaka University (2012)
Osaka Bioscience Institute (2011)

Principal Investigator

OMORI Yoshihiro  大阪大学, 蛋白質研究所, 准教授 (90469651)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords網膜 / 視細胞 / 繊毛 / IFT / ゼブラフィッシュ
Research Abstract

We found that diversity of functional relationships between vertebrate ciliary kinesin motors, and our data shows that the repertoire of kinesin motors changes in some cilia during their differentiation. We also identified ectopic accumulation of transducin in the retinal outer nuclear layer of Mak deficient mice, suggesting the possibility that involvement of Mak in the molecular mechanism of transducin transport through cilia between the photoreceptor outer segments and inner segments.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (19 results)

All 2012 2011 Other

All Journal Article (8 results) (of which Peer Reviewed: 4 results) Presentation (10 results) Remarks (1 results)

  • [Journal Article] Presynaptic dystroglycan-pikachurin complex regulates the proper synaptic connection between retinal photoreceptor and bipolar cells2012

    • Author(s)
      Omori, et al
    • Journal Title

      J Neurosci

      Volume: 32 Issue: 18 Pages: 6126-6137

    • DOI

      10.1523/jneurosci.0322-12.2012

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Kinesin-2 family in vertebrate ciliogenesis2012

    • Author(s)
      Zhao C, Omori Y, et al
    • Journal Title

      Proc Natl Acad Sci USA

      Volume: 109 Issue: 7 Pages: 2388-2393

    • DOI

      10.1073/pnas.1116035109

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] OBIF, an osteoblast induction factor, plays an essential role in bone formation in association with osteoblastogenesis2012

    • Author(s)
      Mizuhashi K
    • Journal Title

      Development, growth and differentiation

      Volume: 54 Issue: 4 Pages: 474-480

    • DOI

      10.1111/j.1440-169x.2012.01333.x

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 一枚の写真館-ニューロンに生える繊毛:細胞のアンテナとしての機能2012

    • Author(s)
      大森義裕
    • Journal Title

      細胞工学

      Volume: 31 Pages: 399-399

    • Related Report
      2012 Final Research Report
  • [Journal Article] ニューロンに生える繊毛:細胞のアンテナとしての機能2012

    • Author(s)
      大森義裕
    • Journal Title

      細胞工学

      Volume: 31 Pages: 399-399

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Analysis of transcriptional regulatory pathways of photoreceptor genes by expression profiling of the Otx2-deficient retina2011

    • Author(s)
      Omori, Y., Katoh, K., Sato, S., Muranishi, Y., Chaya, T., Onishi, A.(代表), Minami, T., Fujikado, T., Furukawa, T.
    • Journal Title

      PLoS One

      Volume: 6(5) Issue: 5 Pages: e19685-e19685

    • DOI

      10.1371/journal.pone.0019685

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] 繊毛キナーゼMak と微小管結合蛋白質 RP1 による繊毛の長さ調節機構2011

    • Author(s)
      大森義裕 , 古川貴久
    • Journal Title

      細胞工学

      Volume: 30 Pages: 536-537

    • Related Report
      2012 Final Research Report
  • [Journal Article] 網膜視細胞の機能構築2011

    • Author(s)
      加藤君子, 荒木章之, 大森義裕, 古川貴久
    • Journal Title

      実験医学

      Volume: 29 Pages: 514-520

    • Related Report
      2012 Final Research Report
  • [Presentation] ICK is required for ciliogenesis in neural progenitor cells and Hedgehog signaling2012

    • Author(s)
      大森義裕
    • Organizer
      日本分子生物学会大会
    • Place of Presentation
      福岡
    • Year and Date
      2012-12-13
    • Related Report
      2012 Final Research Report
  • [Presentation] Photoreceptor degeneration caused by defects of a ciliary kinase2012

    • Author(s)
      Yoshihiro Omori
    • Organizer
      Cilia in development and disease
    • Place of Presentation
      London, UK
    • Year and Date
      2012-05-24
    • Related Report
      2012 Final Research Report
  • [Presentation] ICK is required for ciliogenesis in neural progenitor cells and Hedgehog signaling2012

    • Author(s)
      大森義裕
    • Organizer
      日本分子生物学会
    • Place of Presentation
      マリンメッセ福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Photoreceptor degeneration caused by defects of a ciliary kinase2012

    • Author(s)
      Yoshihiro Omori
    • Organizer
      国際繊毛会議(Cilia in development and disease)
    • Place of Presentation
      Kennedy Lecture Theatre, London, UK
    • Related Report
      2012 Annual Research Report
  • [Presentation] Antagonistic regulation of ciliary length by ciliary kinase Mak and RP1 is required for photoreceptor survival2011

    • Author(s)
      Yoshihiro Omori
    • Organizer
      北米神経科学会
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
    • Related Report
      2012 Final Research Report
  • [Presentation] 網膜視細胞における繊毛局在キナーゼ Mak と微小管結合蛋白質 RP1による繊毛長の制御メカニズム2011

    • Author(s)
      大森義裕
    • Organizer
      日本細胞生物学会大会
    • Place of Presentation
      北海道
    • Year and Date
      2011-06-19
    • Related Report
      2012 Final Research Report
  • [Presentation] A ciliary kinase Mak and a microtubule-associated protein RP1 antagonistically regulate ciliary length in retinal photoreceptor cells2011

    • Author(s)
      大森義裕
    • Organizer
      日本発生生物学会大会
    • Place of Presentation
      沖縄
    • Year and Date
      2011-05-20
    • Related Report
      2012 Final Research Report
  • [Presentation] Antagonistic regulation of ciliary length by ciliary kinase Mak and RP1 is required for photoreceptor survival2011

    • Author(s)
      大森義裕
    • Organizer
      米国神経科学会 年会
    • Place of Presentation
      Washington DC convention center
    • Related Report
      2011 Research-status Report
  • [Presentation] 網膜視細胞における繊毛局在キナーゼMakと微小管結合タンパク質RP1による繊毛長の制御メカニズム2011

    • Author(s)
      大森義裕
    • Organizer
      日本細胞生物学会
    • Place of Presentation
      北海道大学
    • Related Report
      2011 Research-status Report
  • [Presentation] A ciliary kinase Mak and a microtubule-associated protein RP1 antagonistically regulate ciliary length in retinal photoreceptor cells2011

    • Author(s)
      大森義裕
    • Organizer
      日本発生生物学会
    • Place of Presentation
      沖縄コンベンションセンター
    • Related Report
      2011 Research-status Report
  • [Remarks]

    • URL

      http://www.protein.osaka-u.ac.jp/furukawa_lab/

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi