| Project/Area Number |
23790373
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Pathological medical chemistry
|
|---|
| Research Institution | Fukushima Medical University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
|
|---|
| Keywords | β4インテグリン / 癌 / 糖鎖 / β４インテグリン / インテグリン |
|---|
| Research Abstract |
In this study, to elucidate the role of N-glycosylation on β4 integrin, we established the keratinocytes re-expressing wild-type or N-glycosylation-defective β4 integrin in β4 integrin null keratinocytes. The analysis using the keratinocytes indicated that N-glycosylation plays important roles for integrin-mediated cell adhesion and migration. In addition, we found that β4 integrin forms supramolecular complex with EGFR through cross-linking with galectin-3-mediated N-glycans, thereby promoting cellular signaling and the following cellular function.
|
