Transcriptome analysis of gastrointestinal metastasistissues and the significance of cancer stem cells in metastasis

• Project/Area Number: 23790402
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Human pathology
• Research Institution: Hiroshima University
• Principal Investigator: SENTANI Kazuhiro 広島大学, 医歯薬保健学研究院, 助教 (30508164)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 胃癌 / 癌幹細胞マーカー / 粘液形質 / 転移巣 / サイトケラチン

Research Abstract

In the present study, we searched for novel genes associated with tumor metastasis by comprehensive gene expression methods. We immunohistochemically examined expression and distribution of representative cancer stem cells (CSCs) markers ALDH1, CD44 and CD133 in primary tumors and lymph node metastasisof GC. ALDH1 positivity in diffuse-type GC was significantly higher in lymph node metastasis than in the primary tumor. Next, we screened for genes upregulated in GC from microarray and identified the HOXA10 gene. Immunohistochemically, 221 (30%) of 749 GCs were positive for HOXA10, and its expression showed a significant inverse correlation with the depth of invasion and was observed more frequently in the differentiated type of GC. HOXA10 expression was associated with GC with the intestinal mucin phenotype and correlated with CDX2 and MUC2 expression. Furthermore, the prognosis of patients with positive HOXA10 expression was significantly better than in the negative cases. MTT assay and wound healing assay using HOXA10 siRNA indicated that HOXA10 expression inhibits cell growth and motility. These results suggest that expression of HOXA10 may be a key regulator for GC with the intestinal mucin phenotype.

Research Products

• [Journal Article] Expression of miR-486 is a potential prognostic factor after nephrectomy in advanced renal cell carcinoma (2013)
  • Author(s): Goto K, Oue N, Shinmei S, Sentani K, Sakamoto N, Naito Y, Hayashi T, Teishima J, Matsubara A and Yasui W
  • Journal Title: Mol Clin Oncol Volume: 1 Pages: 235-240
  • Peer Reviewed
• [Journal Article] The search for secreted protein in prostate cancer by the Escherichia coli ampicillin secretion trap: Expression of NBL1 is highly restricted in prostate and related in progression. (2013)
  • Author(s): Hayashi T, Sentani K, Oue N, Ohara S, Teishima J, Anami K, Sakamoto N, Matsubara A and Yasui W
  • Journal Title: Pathobiology Volume: 80 Pages: 60-69
  • Peer Reviewed
• [Journal Article] Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: A characteristic pattern is associated with sessile serrated lesion. (2013)
  • Author(s): Kazuhiro Sentani
  • Journal Title: Histopathology Volume: In press
  • Peer Reviewed
• [Journal Article] Expression of miR-486 is a potential prognostic factor after nephrectomy in advanced renal cell carcinoma. (2013)
  • Author(s): Keisuke Goto
  • Journal Title: Molecular and Clinical Oncology Volume: 1 Pages: 235-240
  • Peer Reviewed
• [Journal Article] Infantile adenomyoma subclinically excreted in the diaper (2012)
  • Author(s): Anami K, Sentani K, Sakamoto N, Uraoka N, Oue N and Yasui W
  • Journal Title: Pathol Int Volume: 62 Pages: 532-537
  • Peer Reviewed
• [Journal Article] Primary mammary mucinous cystadenocarcinoma: cytological and histological findings (2012)
  • Author(s): Sentani K, Tashiro T, Uraoka N, Aosaki Y, Yano S, Takaeko F and Yasui W
  • Journal Title: Diagn Cytopathol Volume: 40 Pages: 624-628
  • Peer Reviewed
• [Journal Article] Reg IV is a direct target of intestinal transcription factor CDX2 in gastric cancer. (2012)
  • Author(s): Naito Y, Oue N, Hinoi T, Sakamoto N, Sentani K, Ohdan H, Yanagihara K, Sasaki H and Yasui W
  • Journal Title: PLoS One Volume: 7(11)
  • Peer Reviewed
• [Journal Article] Clinicopathologic features of minute pharyngeal lesions diagnosed by narrow banding imaging endoscopy and biopsy. (2012)
  • Author(s): Kumamoto T, Sentani K, Oka S, Tanaka S and Yasui W
  • Journal Title: World J Gastroenterol Volume: 18 Pages: 6468-6474
  • Peer Reviewed
• [Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer (2012)
  • Author(s): Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Oo HZ, Naito Y, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H and Yasui W
  • Journal Title: Cancer Sci Volume: 103 Pages: 1744-1750
  • Peer Reviewed
• [Journal Article] Upregulation of HOXA10 in gastric cancer with the intestinal mucin phenotype: Reduction during tumor progression and favorable prognosis. (2012)
  • Author(s): Sentani K, Oue N, Naito Y, Sakamoto N, Anami K, Oo HZ, Uraoka N, Aoyagi K, Sasaki H and Yasui W
  • Journal Title: Carcinogenesis Volume: 33 Pages: 1081-1088
  • NAID: 120005308208
  • Peer Reviewed
• [Journal Article] Cytokeratin expression profiling in gastric carcinoma: clinicopathologic significance and comparison with tumor-associated molecules (2012)
  • Author(s): Takami H, Sentani K, Matsuda M, Oue N, Sakamoto N and Yasui W:
  • Journal Title: Pathobiology Volume: 79 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Cytokeratin 7 is a predictive marker for survival in patients with esophageal squamous cell carcinoma. (2012)
  • Author(s): Oue N, Noguchi T, Anami K, Kitano S, Sakamoto N, Sentani K, Uraoka N, Aoyagi K, Yoshida T, Sasaki H and Yasui W
  • Journal Title: Ann Surg Oncol Volume: 19 Pages: 1902-1910
  • Peer Reviewed
• [Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1beta, and atrophic gastritis in mice (2012)
  • Author(s): Hayashi D, Tamura A, Tanaka H, Yamazaki Y, Watanabe S, Suzuki K, Suzuki K, Sentani K, Yasui W, Rakugi H, Isaka Y and Tsukita S
  • Journal Title: Gastroenterology Volume: 142 Pages: 292-304
  • Peer Reviewed
• [Journal Article] Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer (2012)
  • Author(s): Wakamatsu Y, Sakamoto N, Oo HZ, Naito Y, Uraoka N, Anami K, Sentani K, Oue N and Yasui W
  • Journal Title: Pathol Int Volume: 62 Pages: 112-119
  • NAID: 10031185176
  • Peer Reviewed
• [Journal Article] MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma. (2012)
  • Author(s): Shinmei S, Sakamoto N, Goto K, Sentani K, Anami K, Hayashi T, Teishima J, Matsubara A, Oue N, Kitadai Y, Yasui W.
  • Journal Title: Int J Urol Volume: - Issue: 5 Pages: 468-477
  • DOI: 10.1111/j.1442-2042.2012.03182.x
  • Peer Reviewed
• [Journal Article] Infantile adenomyoma subclinically excreted into the patient's diaper. (2012)
  • Author(s): Anami K, Sentani K, Sakamoto N, Uraoka N, Oue N, Yasui W.
  • Journal Title: Pathol Int Volume: 62 Issue: 8 Pages: 532-537
  • DOI: 10.1111/j.1440-1827.2012.02829.x
  • Peer Reviewed
• [Journal Article] Primary mammary mucinous cystadenocarcinoma: cytological and histological findings. (2012)
  • Author(s): Kazuhiro Sentani
  • Journal Title: Diagnostic Cytopathology Volume: 40 Issue: 7 Pages: 624-628
  • DOI: 10.1002/dc.21638
  • Peer Reviewed
• [Journal Article] Reg IV is a direct target of intestinal transcriptional factor CDX2 in gastric cancer. (2012)
  • Author(s): Naito Y, Oue N, Hinoi T, Sakamoto N, Sentani K, Ohdan H, Yanagihara K, Sasaki, H, Yasui W.
  • Journal Title: PLoS One Volume: 7(11) Issue: 11 Pages: 47545-47545
  • DOI: 10.1371/journal.pone.0047545
  • Peer Reviewed
• [Journal Article] Clinicopathologic features of minute pharyngeal lesions diagnosed by narrow banding imaging endoscopy and biopsy. (2012)
  • Author(s): Takashi Kumamoto
  • Journal Title: World Journal of Gastroenterology Volume: 18 Issue: 44 Pages: 6468-6474
  • DOI: 10.3748/wjg.v18.i44.6468
  • Peer Reviewed
• [Journal Article] Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer (2012)
  • Author(s): Sakamoto N, Oue N, Sentani K, Anami K, Uraoka N, Naito Y, Oo HZ, Hinoi T, Ohdan H, Yanagihara K, Aoyagi K, Sasaki H, Yasui W.
  • Journal Title: Liver-intestine cadherin induction by epidermal growth factor receptor is associated with intestinal differentiation of gastric cancer Volume: 103(9) Issue: 9 Pages: 1744-50
  • DOI: 10.1111/j.1349-7006.2012.02353.x
  • Peer Reviewed
• [Journal Article] Cytokeratin expression profiling in gastric carcinoma: clinicopathologic significance and comparison with tumor-associated molecules. (2012)
  • Author(s): Takami H, Sentani K, Matsuda M, Oue N, Sakamoto N, Yasui W.
  • Journal Title: Pathobiology Volume: 79 Issue: 3 Pages: 154-161
  • DOI: 10.1159/000335694
  • Peer Reviewed
• [Journal Article] Deficiency of claudin-18 causes paracellular H+ leakage, up-regulation of interleukin-1β, and atrophic gastritis in mice. (2012)
  • Author(s): Hayashi, D., Tamura, A., Tanaka, H., Yamazaki, Y., Watanabe S. Suzuki, K., Suzuki, K. Sentani, K., Yasui, W., Rakugi, H., Isaka, Y., and Tsukita, S.
  • Journal Title: Gastroenterology Volume: 142 Issue: 2 Pages: 292-304
  • DOI: 10.1053/j.gastro.2011.10.040
  • Peer Reviewed
• [Journal Article] Expression of cancer stem cell markers ALDH1, CD44 and CD133 in primary tumor and lymph node metastasis of gastric cancer. (2012)
  • Author(s): Wakamatsu Y, Sakamoto N, Oo HZ, Naito Y, Uraoka N, Anami K, Sentani K, Oue N, Yasui W.
  • Journal Title: Pathol Int Volume: 62 Issue: 2 Pages: 112-119
  • DOI: 10.1111/j.1440-1827.2011.02760.x
  • Peer Reviewed
• [Journal Article] Claudin-based paracellular proton barrier in the stomach. (2012)
  • Author(s): Tamura A., et al
  • Journal Title: Ann N Y Acad Sci. Volume: 1,258 Issue: 1 Pages: 108-114
  • DOI: 10.1111/j.1749-6632.2012.06570.x
  • Peer Reviewed
• [Journal Article] Cytokeratin 7 is a Predictive Marker for Survival (2012)
  • Author(s): Naohide Oue et al.
  • Journal Title: Annals of Surgical Oncology Volume: -
  • Peer Reviewed
• [Journal Article] Cytokeratin expression profiling in gastric (2012)
  • Author(s): Hokuto Takami et al.
  • Journal Title: Pathobiology Volume: 79 Pages: 154-161
  • Peer Reviewed
• [Journal Article] Upregulation of HOXA10 in gastric cancer (2012)
  • Author(s): Kazuhiro Sentani et al.
  • Journal Title: Carcinogenesis Volume: -
  • Peer Reviewed
• [Journal Article] Identification of transmembrane protein in prostate cancer by the Escherichia coli ampicillin secretion trap: Expression of CDON is involved in tumor cell growth and invasion (2011)
  • Author(s): Hayashi T, Oue N, Sakamoto N, Anami K, Oo HZ, Sentani K, Ohara S, Teishima J, Matsubara A and Yasui W
  • Journal Title: Pathobiology Volume: 78 Pages: 277-284
  • Peer Reviewed
• [Journal Article] Desmocollin 2 is a new immunohistochemical marker indicative of squamous cell carcinoma differentiation in urothelial carcinoma (2011)
  • Author(s): Hayashi T, Sentani K, Oue N, Anami K, Sakamoto N, Ohara S, Teishima J, Noguchi T, Nakayama H, Taniyama, Matsubara A and Yasui W
  • Journal Title: Histopathology Volume: 59 Pages: 710-721
  • Peer Reviewed
• [Journal Article] Serum concentration and expression of Reg IV in patients with esophageal cancer: age-related elevation of serum Reg IV concentration (2011)
  • Author(s): Oue N, Noguchi T, Anami K, Sentani K, Sakamoto N, Uraoka N, Wakamatsu Y, Sasaki H and Yasui W
  • Journal Title: Oncol Lett Volume: 2 Pages: 235-239
  • Peer Reviewed
• [Journal Article] Cytokeratin 7 is a Predictive Marker for Survival in Patients with Esophageal Squamous Cell Carcinoma (2011)
  • Author(s): Naohide Oue, Tsuyoshi Noguchi, Wataru Yasui.(他8名, 2番目)
  • Journal Title: Ann Surg Oncol. Volume: 19 Issue: 6 Pages: 1902-1910
  • DOI: 10.1245/s10434-011-2175-4
  • Peer Reviewed
• [Journal Article] Identification of transmembrane protein in prostat (2011)
  • Author(s): Tetsutaro Hayashi et al.
  • Journal Title: Pathobiology Volume: 78 Pages: 277-284
  • Peer Reviewed
• [Journal Article] Molecular pathology of gastric cancer: research and practice. (2011)
  • Author(s): Yasui W, Sentani K, Sakamoto N, Anami K, Naito Y, Oue N.
  • Journal Title: Pathol Res Pract Volume: 207 Issue: 10 Pages: 608-612
  • DOI: 10.1016/j.prp.2011.09.006
  • Peer Reviewed
• [Journal Article] Desmocollin 2 is a newimmunohistochemical marker indicative ofsquamous differentiation in urothelialcarcinoma (2011)
  • Author(s): Hayashi T, Ohara S, Teishima J, MatsubaraA, Yasui W
  • Journal Title: Histopathology Volume: 59 Issue: 4 Pages: 710-721
  • DOI: 10.1111/j.1365-2559.2011.03988.x
  • Peer Reviewed
• [Journal Article] Deficiency of claudin-18 causes paracellular H+ (2011)
  • Author(s): Daisuke Hayashi et al.
  • Journal Title: Gastroenterology Volume: 142 Pages: 292-304
  • Peer Reviewed
• [Journal Article] Expression of olfactomedin 4 and claudin-18 in serrated neoplasia of the colorectum: A characteristic pattern is associated with sessile serrated lesion.
  • Author(s): Sentani K, Sakamoto N, Shimamoto F, Anami K, Oue N and Yasui W
  • Journal Title: Histopathology Volume: (in press)
  • Peer Reviewed
• [Journal Article] MicroRNA-155 is a predictive marker for survival in patients with clear cell renal cell carcinoma
  • Author(s): Shinmei S, Sakamoto N, Goto K, Sentani K, Anami K, Hayashi T, Teishima J, Matsubara A, Oue N Kitadai Y and Yasui W
  • Journal Title: Int J Urol Volume: (in press)
  • NAID: 10031177678
  • Peer Reviewed
• [Presentation] 大腸鋸歯状病変におけるolfactomedin 4とclaudin-18の発現パターンの検討 (2012)
  • Author(s): 仙谷和弘,坂本直也,大上直秀,嶋本文雄,安井 弥
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 乳腺原発mucinous cystadenocarcinoma の一例 (2012)
  • Author(s): 仙谷和弘,浦岡直礼,田代 敬,坂本直也,大上直秀,安井 弥
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 大腸鋸歯状病変におけるolfactomedin 4とclaudin-18の発現パターンの検討． (2012)
  • Author(s): 仙谷 和弘
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 乳腺原発mucinous cystadenocarcinoma の一例． (2012)
  • Author(s): 仙谷 和弘
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 食道癌術後補助療法の効果予測マーカーとしてのサイトケラチン7． (2012)
  • Author(s): 大上 直秀
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 胃癌におけるDNAメチル化によるmiR-148aの発現低下とMMP7を介した浸潤への関与． (2012)
  • Author(s): 坂本 直也
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] スキルス胃癌におけるmicroRNA-143の発現と機能解析． (2012)
  • Author(s): 内藤 寛
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 進行腎細胞癌におけるmiR-486の発現上昇と予後との相関． (2012)
  • Author(s): 後藤 景介
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 乳児の発生し、便中に自然排泄されたAdenomyomaの1例． (2012)
  • Author(s): 阿南 勝宏
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 食道扁平上皮癌を用いたSAGE法による解析：新規マーカーNRD1の同定． (2012)
  • Author(s): 浦岡 直礼
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] エクソソーム構成分子TSPAN8の胃癌における発現と予後との関連および生物学的機能に関する検討． (2012)
  • Author(s): 阿南 勝宏
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 高腹膜播種能を有するスキルス胃癌細胞株を用いたCAST法による解析． (2012)
  • Author(s): Htoo Zarni Oo
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 進行性腎細胞癌における予後因子としてのmiR-155の意義． (2012)
  • Author(s): 神明 俊輔
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 大腸癌パラフィン切片を用いたmiR-21の発現解析と薬剤感受性・予後との関連． (2012)
  • Author(s): 大上 直秀
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] 子宮頸部病変におけるDNAメチル化異常の検討（第2報）． (2012)
  • Author(s): 坂根 潤一
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 東京
• [Presentation] Transcriptome analysis of esophageal squamous cell carcinoma by SAGE identifies a new biomarker, NRD1. (2012)
  • Author(s): Naohiro Uraoka
  • Organizer: The 103rd Annual Meeting of the American Association for Cancer Research
  • Place of Presentation: Chicago, USA
• [Presentation] SPC（SEC11A）によるEGF、TGF-aの分泌促進と胃癌における意義． (2012)
  • Author(s): 大上 直秀
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: 広島
• [Presentation] MiR-148aの胃癌における発現低下とMMP7を介した浸潤への関与． (2012)
  • Author(s): 坂本 直也
  • Organizer: 第21回日本がん転移学会学術集会・総会
  • Place of Presentation: 広島
• [Presentation] SAGE法で同定された食道扁平上皮癌の新規マーカーNRD1の解析． (2012)
  • Author(s): 浦岡 直礼
  • Organizer: 第31回分子病理学会研究会
  • Place of Presentation: 岐阜
• [Presentation] microRNA-143のスキルス胃癌における機能解析． (2012)
  • Author(s): 内藤 寛
  • Organizer: 第9回日本病理学会カンファレンス
  • Place of Presentation: 山口
• [Presentation] 高腹膜播種能を有するスキルス胃癌細胞株を用いたCAST法による解析：ZDHHC14の細胞生物学的機能への影響． (2012)
  • Author(s): Htoo Zarni Oo
  • Organizer: 第9回日本病理学会カンファレンス
  • Place of Presentation: 山口
• [Presentation] スキルス胃癌におけるmicroRNA-143の機能解析と腫瘍マーカーとしての有用性． (2012)
  • Author(s): 内藤 寛
  • Organizer: 第32回日本分子腫瘍マーカー研究会
  • Place of Presentation: 札幌
• [Presentation] エクソソーム構成分子TSPAN8の胃癌における発現と分子病理学的検討． (2012)
  • Author(s): 阿南 勝宏
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] スキルス胃癌におけるmiR-143の機能解析． (2012)
  • Author(s): 内藤 寛
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 食道扁平上皮癌に対するAdjuvant therapy効果予測因子としてのサイトケラチン7 (2012)
  • Author(s): 大上 直秀
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] SAGE法により同定された食道扁平上皮癌の新規マーカーNRD1の解析． (2012)
  • Author(s): 浦岡 直礼
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 胃癌で発現が低下しているmiR-148aはMMP7を標的とし、浸潤に関与する． (2012)
  • Author(s): 坂本 直也
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 進行腎細胞癌におけるmiR-486発現の予後予測因子としての意義． (2012)
  • Author(s): 後藤 景介
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] CAST法によるスキルス胃癌組織における遺伝子発現解析． (2012)
  • Author(s): 今本 奈緒
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 大腸がんにおけるTransmembrane 9 super family member 3（TM9SF3）発現の重要性． (2012)
  • Author(s): 山本 利枝
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] 子宮頸癌スクリーニング液状細胞診検体を用いたエピジェネティック異常の検出． (2012)
  • Author(s): 坂根潤一
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] Identification of gene expression profile in scirrhous type gastric cancer cell lines by CAST method． (2012)
  • Author(s): Htoo Zarni Oo
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] microRNA-155発現の腎細胞癌における予後予測因子としての意義． (2012)
  • Author(s): 神明 俊輔
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] CAST法で同定したTMEM50Bの発現は前立腺癌の進展と相互する． (2012)
  • Author(s): 林 哲太郎
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: 札幌
• [Presentation] NBI拡大内視鏡検査により診断された食道微小病変の臨床病理学的検討． (2012)
  • Author(s): 熊本 隆
  • Organizer: 第84回日本消化器内視鏡学会
  • Place of Presentation: 神戸
• [Presentation] 急激に全身状態の悪化を来たし死亡したpseudomesotheliomatous carcinomaの1例 (2012)
  • Author(s): 坂本 直也
  • Organizer: 第58回日本病理学会秋期特別総会
  • Place of Presentation: 名古屋
• [Presentation] インテグリンα8β1は活性化星細胞に発現し肝線維化を促進する． (2012)
  • Author(s): 西道 教尚
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Presentation] スキルス胃癌におけるmicroRNA-143の機能の解析． (2012)
  • Author(s): 内藤 寛
  • Organizer: 第35回日本分子生物学会年会
  • Place of Presentation: 福岡
• [Presentation] Upregulation of HOX10 in intestinal phenotype gastric cancer: Reduction during tumor progression and favorable prognosis. (2011)
  • Author(s): Sentani K, Oue N, Sakamoto N, Naito Y, Anami K, Oo HZ, Uraoka N and Yasui W
  • Organizer: The 21stInternational Symposium of the Hiroshima Cancer Seminar "Recent Progress in Carcinogenesis, Progression and Management of Upper GI Cancer"
  • Place of Presentation: Hiroshima (Japan)
  • Year and Date: 2011-11-06
• [Presentation] 大腸鋸歯状病変におけるolfactomedin4とclaudin-18の発現パターンの検討 (2011)
  • Author(s): 仙谷和弘,大上直秀,坂本直也,阿南勝宏,安井 弥
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] 遺伝子発現プロファイルで同定したHOXA10は胃癌の予後良好因子である (2011)
  • Author(s): 仙谷和弘,大上直秀,坂本直也,浦岡直礼,安井 弥
  • Organizer: 第20回日本がん転移学会学術集会・総会
  • Place of Presentation: 浜松
• [Presentation] 大腸鋸歯状病変におけるolfactomedin4とclaudin-18の発現と臨床病理学的意義 (2011)
  • Author(s): 仙谷和弘,大上直秀,坂本直也,阿南勝宏,安井 弥
  • Organizer: 第100回日本病理学会総会
  • Place of Presentation: 横浜
• [Presentation] 遺伝子発現プロファイルで同定したHOXA10は胃癌の予後良好因子である (2011)
  • Author(s): 仙谷 和弘
  • Organizer: 第20回日本がん転移学会学術集会
  • Place of Presentation: 浜松
• [Presentation] Upregulation of HOX10 in intestinal phenotype (2011)
  • Author(s): Kazuhiro Sentani
  • Organizer: The 21st International Symposium of the Hiroshima
  • Place of Presentation: 広島
• [Book] Principle of molecular diagnostics and personalized cancer therapy (2013)
  • Author(s): Wataru Yasui
  • Publisher: Lippincott Williams & Wilkins
• [Book] Molecular diagnostics of esophageal and gastric cancer. In: Principle of molecular diagnostics and personalized cancer therapy
  • Author(s): Yasui W, Oue N and Sentani K
  • Publisher: Lippincott Williams & Wilkins, Philadelphia(In press)
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byori1/
• [Remarks] 広島大学大学院医歯薬保健学研究院分子病理学研究室
  • URL: http://home.hiroshima-u.ac.jp/byori1/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/byori1/