Function analysis of SGSM family and RAB11 which associate with the vesicular transportation of prion protein

Research Project

Project/Area Number	23790418
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Human pathology
Research Institution	Keio University
Principal Investigator	YANG Hao 慶應義塾大学, 医学部, 特任助 (10464992)
Project Period (FY)	2011 – 2012
Project Status	Completed (Fiscal Year 2012)
Budget Amount *help	¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000) Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	脳・神経 / プリオンタンパク / SGSMファミリータンパク / 神経 / RABファミリータンパク
Research Abstract	SGSM family proteins interact with RAB11 which regulates the vesicular transportation of prion protein, and might participate in the pathogenesis of hereditary prion disease. The association between SGSM family and RAB family was analyzed by molecular bio