Protective Roles of Epithelial Cells in the Survival of Adult T-Cell Leukemia Cells
| Project/Area Number |
23790430
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Experimental pathology
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| Research Institution | Hokkaido University |
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Principal Investigator |
MIYATAKE Yukiko 北海道大学, 大学院・医学研究科, 助教 (10421984)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | ウイルス感染症 / HTLV-1 / ATL / 癌幹細胞 / CD44 / 細胞間相互作用 / 国際情報交流 |
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| Research Abstract |
Adult T-cell leukemia (ATL) is a highly invasive and intractable T-cell malignancy caused by HTLV-1 infection. We demonstrate here that normal tissue-derived epithelial cells (NECs) exert protective effects on the survival of leukemic cells, which may partially account for high resistance to anti-leukemic therapies in ATL patients. A propensity of leukemia cells to infiltrate into epithelial tissues might produce at least two pathologic outcomes in ATL patients: the survival of leukemia cells through acquisition of cancer stem cell-like phenotypes and the evasion of the host immune response.
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Report
(3 results)
Research Products
(26 results)
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[Journal Article] Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells.2013
Author(s)
Miyatake, Y., Oliveira, A. L. A., Jarboui, M.A., Ota, S., Tomaru, U., Teshima, T., Hall, W. W. and Kasahara, M
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Journal Title
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Peer Reviewed
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[Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities2012
Author(s)
Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
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Journal Title
Am.J.Pathol.
Volume: 180
Issue: 3
Pages: 963-972
DOI
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Peer Reviewed
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[Presentation] プロテアソーム機能に着目した老化,脂質代謝異常の病態解明2011
Author(s)
外丸詩野,高橋里美,宮武由甲子,小野綾子,小原次郎,紺野沙織,村田茂穂,田中啓二,石津明洋,笠原正典
Organizer
第44回北海道病理談話会
Place of Presentation
旭川市国際会議場(北海道)
Year and Date
2011-09-10
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[Presentation] New insights into cell-cell interactions between adult T-cell leukemia cells and endothelial cells. The XXV Symposium of the International Association for Comparative Research on Leukemia andRelated Diseases2011
Author(s)
Miyatake, Y., Tomaru, U., Oliveira, L.A., Sheehy, N., Hall, W.W. and Kasahara, M
Organizer
Molecular Pathogenesis and Translational Research in Leukemia and Lymphoma
Place of Presentation
Tokyo (The University of Tokyo)
Related Report
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[Presentation] Sromal cells help ATL cells to escape from apoptosis induced by histone deacetylase inhibitors Retrovirology 20118(Suppl 1)2011
Author(s)
Miyatake, Y., Tomaru, U., Oliveira, A.L.,Sheehy, N., Yoshiki, T., Kasahara, M. and Hall, W.W
Organizer
15th International Conference on Human Retrovirology: HTLV and Related Retroviruses Leuven
Place of Presentation
Belgium
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