Protective Roles of Epithelial Cells in the Survival of Adult T-Cell Leukemia Cells

• Project/Area Number: 23790430
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Hokkaido University
• Principal Investigator: MIYATAKE Yukiko 北海道大学, 大学院・医学研究科, 助教 (10421984)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000); Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ウイルス感染症 / HTLV-1 / ATL / 癌幹細胞 / CD44 / 細胞間相互作用 / 国際情報交流

Research Abstract

Adult T-cell leukemia (ATL) is a highly invasive and intractable T-cell malignancy caused by HTLV-1 infection. We demonstrate here that normal tissue-derived epithelial cells (NECs) exert protective effects on the survival of leukemic cells, which may partially account for high resistance to anti-leukemic therapies in ATL patients. A propensity of leukemia cells to infiltrate into epithelial tissues might produce at least two pathologic outcomes in ATL patients: the survival of leukemia cells through acquisition of cancer stem cell-like phenotypes and the evasion of the host immune response.

Research Products

• [Journal Article] Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. (2013)
  • Author(s): Miyatake, Y., Oliveira, A. L. A., Jarboui, M.A., Ota, S., Tomaru, U., Teshima, T., Hall, W. W. and Kasahara, M
  • Journal Title: Am.J. Pathol Volume: 182
  • Peer Reviewed
• [Journal Article] Protective roles of epithelial cells in the survival of adult T-cell leukemia/lymphoma cells. (2013)
  • Author(s): Miyatake Yukiko
  • Journal Title: The American Journal of Pathology Volume: 182 Issue: 5 Pages: 1832-1842
  • DOI: 10.1016/j.ajpath.2013.01.015
  • Peer Reviewed
• [Journal Article] Decreased proteasomal activity causes age-related phenotypes and promotes the development of metabolic abnormalities (2012)
  • Author(s): Tomaru U, Takahashi S, Ishizu A, Miyatake Y, Gohda A, Suzuki S, Ono A, Ohara J, Baba T, Murata S, Tanaka K, Kasahara M
  • Journal Title: Am.J.Pathol. Volume: 180 Issue: 3 Pages: 963-972
  • DOI: 10.1016/j.ajpath.2011.11.012
  • Peer Reviewed
• [Presentation] Inactivationof Skint1 in hominoids but not in Old World monkeys (2013)
  • Author(s): Mohamed, R. H., Sutoh, Y., Otsuka, N., Miyatake, Y. and Kasahara, M.
  • Organizer: 第32回日本胸腺研究会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2013-02-09
• [Presentation] 胎盤形成と妊娠維持へのNKG2Dリガンドの関与 (2012)
  • Author(s): 山本菜見子,大塚紀幸,宮武由甲子,吉田繁,笠原正典
  • Organizer: 第27回日本生殖免疫学会
  • Place of Presentation: 大阪医科大学(高槻市)
  • Year and Date: 2012-12-08
• [Presentation] Contact with epithelial cells induces cancer stem cell-like properties in adult T-cell leukemia/lymphoma cells (2012)
  • Author(s): Miyatake, Y., Tomaru, U., Hall, W. W. and Kasahara, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際展示場(兵庫県)
  • Year and Date: 2012-12-07
• [Presentation] Involvement of an NKG2D ligand H60c in epidermal dendritic T cell-mediated wound repair (2012)
  • Author(s): Rania, H. M., Yoshida, S., Miyatake, Y., Otsuka, N. and Kasahara, M.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場(兵庫県)
  • Year and Date: 2012-12-05
• [Presentation] 胎盤形成と妊娠維持へのNKG2Dリガンドの関与 (2012)
  • Author(s): 山本菜見子,大塚紀幸,宮武由甲子,吉田繁,笠原正典
  • Organizer: 第45回北海道病理談話会
  • Place of Presentation: 札幌医科大学(札幌市)
  • Year and Date: 2012-10-13
• [Presentation] 上皮細胞は接着している成人T細胞白血病細胞を細胞静止状態にして保護する (2012)
  • Author(s): 宮武由甲子,外丸詩野,笠原正典
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌(北海道)
  • Year and Date: 2012-09-19
• [Presentation] 成人T細胞白血病における上皮細 胞の潜在的役割 (2012)
  • Author(s): 宮武由甲子,Andre, L. A. O,Noreen, S.,大塚紀幸,外丸詩野,Hall , W. W., 笠原正典
  • Organizer: 第92回北海道医学大会
  • Place of Presentation: 北海道大学(札幌市)
  • Year and Date: 2012-09-08
• [Presentation] VLRC defines a population of lamprey lymphocytes distinct from that expressing VLRA or VLRB (2012)
  • Author(s): Sutoh, Y., Kasamatsu, J., Otsuka, N., Miyatake, Y. and Kasahara, M
  • Organizer: The 12th International Congress of the International Society for Developmental and ComparativeImmunology
  • Place of Presentation: Fukuoka (Hilton Fukuoka SeaHawk Hotel)
  • Year and Date: 2012-07-10
• [Presentation] 成人T細胞白血病(ATL)の病態における上皮細胞の役割の検討 (2012)
  • Author(s): 宮武由甲子,外丸詩野,Noreen Sheehy,石津明洋,William W. Hall,笠原正典
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 京王プラザホテル(東京都)
  • Year and Date: 2012-04-28
• [Presentation] Contact with epithelial cells induces cancer stem cell-like properties in adult T-cell leukemia/lymphoma cells． (2012)
  • Author(s): 宮武 由甲子
  • Organizer: 第４１回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（兵庫県）
• [Presentation] 上皮細胞は接着している成人T細胞白血病細胞を細胞静止状態にして保護する (2012)
  • Author(s): 宮武 由甲子
  • Organizer: 第７１回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] 成人T細胞白血病における上皮細胞の潜在的役割 (2012)
  • Author(s): 宮武 由甲子
  • Organizer: 第92回北海道医学大会
  • Place of Presentation: 北海道大学（札幌市）
• [Presentation] 成人T細胞白血病（ATL）の病態における上皮細胞の役割の検討 (2012)
  • Author(s): 宮武 由甲子
  • Organizer: 第101回日本病理学会総会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] プロテアソーム機能に着目した老化,脂質代謝異常の病態解明 (2011)
  • Author(s): 外丸詩野,高橋里美,宮武由甲子,小野綾子,小原次郎,紺野沙織,村田茂穂,田中啓二,石津明洋,笠原正典
  • Organizer: 第44回北海道病理談話会
  • Place of Presentation: 旭川市国際会議場(北海道)
  • Year and Date: 2011-09-10
• [Presentation] New insights into cell-cell interactions between adult T-cell leukemia cells and endothelial cells. The XXV Symposium of the International Association for Comparative Research on Leukemia andRelated Diseases (2011)
  • Author(s): Miyatake, Y., Tomaru, U., Oliveira, L.A., Sheehy, N., Hall, W.W. and Kasahara, M
  • Organizer: Molecular Pathogenesis and Translational Research in Leukemia and Lymphoma
  • Place of Presentation: Tokyo (The University of Tokyo)
• [Presentation] Sromal cells help ATL cells to escape from apoptosis induced by histone deacetylase inhibitors Retrovirology 20118(Suppl 1) (2011)
  • Author(s): Miyatake, Y., Tomaru, U., Oliveira, A.L.,Sheehy, N., Yoshiki, T., Kasahara, M. and Hall, W.W
  • Organizer: 15th International Conference on Human Retrovirology: HTLV and Related Retroviruses Leuven
  • Place of Presentation: Belgium
• [Presentation] 胸腺プロテアソームの異所性発現によるT細胞分化の異常 (2011)
  • Author(s): 小原次郎,外丸詩野,鈴木小百合,高橋里美,宮武由甲子,村田茂穂,田中啓二,石津明洋,笠原正典
  • Organizer: 第100回日本病理学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] プロテアソームの機能異常による病理作用:脂質代謝や脂肪肝との関連性について (2011)
  • Author(s): 高橋里美,外丸詩野,合田文,小野綾子,小原次郎,宮武由甲子,村田茂穂,田中啓二,石津明洋,笠原正典
  • Organizer: 第100回日本病理学会
  • Place of Presentation: パシフィコ横浜(神奈川県)
• [Presentation] 間質細胞はHDAC阻害剤によって誘導されるアポトーシスを回避を助ける (2011)
  • Author(s): 宮武 由甲子
  • Organizer: 第15回国際レトロウイルス学会
  • Place of Presentation: ルーベン大学、ベルギー
• [Presentation] ＡＴＬ細胞と上皮細胞との細胞間相互作用における新しい作用 (2011)
  • Author(s): 宮武 由甲子
  • Organizer: 第25回国際比較白血病学会
  • Place of Presentation: 東京大学、東京
• [Presentation] ＡＴＬ細胞と上皮細胞との細胞間相互作用における新しい作用 (2011)
  • Author(s): 宮武 由甲子
  • Organizer: 第４回HTLV-1研究会
  • Place of Presentation: 東京大学、東京
• [Presentation] HTLV-1持続潜伏感性における上皮系細胞の役割 (2011)
  • Author(s): 宮武 由甲子
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 幕張メッセ、千葉
• [Remarks]
  • URL: http://www.path1-hokudai.jp/path1/Welcome.html