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The mechanism of diabetes development by impairment of VEGF signal between islet cells

Research Project

Project/Area Number 23790431
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionChiba University

Principal Investigator

KAWAMURA Harukiyo  千葉大学, 医学部附属病院, 助教 (70527902)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords糖尿病 / VEGF / 膵島 / 血管内皮細胞 / SDTラット / モデル動物
Research Abstract

SDT rats, a model of non-obese spontaneous diabetes mellitus, exhibit vascular abnormalities within pancreatic islets as the initial changes, followed by β-cell deterioration. The present study revealed that enhanced signaling of VEGF in vascular endothelial cells is induced by excessive IL-1β secretion from β-cells. Moreover, increased VEGF secretion has been shown to be occurred after enhanced VEGF signaling, which causes vicious cycle of VEGF signaling. These results elucidated the mechanism by which the failure of normal VEGF signaling induces β-cell injury, microvascular failure, and consequential diabetes.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (27 results)

All 2013 2012 Other

All Journal Article (6 results) (of which Peer Reviewed: 6 results) Presentation (18 results) Book (3 results)

  • [Journal Article] Atorvastatin ameliorates podocyte injury in patients with type 2 diabetes complicated with dyslipidemia.2013

    • Author(s)
      Takemoto M, Ishikawa T, Onishi S, Okabe E, Ishibashi R, He P, Kobayashi K, Fujimoto M, Kawamura H, Yokote K
    • Journal Title

      Diabetes Res Clin Pract

      Volume: 100 Issue: 1 Pages: e26-e29

    • DOI

      10.1016/j.diabres.2012.12.018

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sitagliptin successfully ameliorates glycemic control in werner syndrome with diabetes2012

    • Author(s)
      Kitamoto T, Takemoto M, Fujimoto M, Ishikawa T, Onishi S, Okabe E, Ishibashi R, Kobayashi K, Kawamura H, Yokote K
    • Journal Title

      Diabetes Care

      Volume: Diabetes Care Issue: 12 Pages: e83-e83

    • DOI

      10.2337/dc12-1179

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese diabetic patients with Werner syndrome exhibit high incidence of cancer.2012

    • Author(s)
      Onishi S
    • Journal Title

      Acta Diabetol

      Volume: 49 Issue: S1 Pages: 259-260

    • DOI

      10.1007/s00592-012-0424-z

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and characteristics of metabolic disorders and vascular complications in Werner syndrome patients in Japan2012

    • Author(s)
      Okabe E, Takemoto M, Onishi S, Ishikawa T, Ishibashi R, He P, Kobayashi K, Fujimoto M, Kawamura H, Yokote K
    • Journal Title

      J Am Geriatr Soc

      Volume: 60(5) Issue: 5 Pages: 997-998

    • DOI

      10.1111/j.1532-5415.2012.03944.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Japanese diabetic patients with Werner syndrome exhibit high incidence of cancer2012

    • Author(s)
      Onishi S,
    • Journal Title

      Acta Diabetol

      Volume: 49 Issue: 6 Pages: 259-260

    • DOI

      10.1002/biof.1038

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Incidence and characteristics of metabolic disorders and vascular complications in Werner syndrome patients in Japan2012

    • Author(s)
      Okabe E, et al.
    • Journal Title

      J. Am. Geriatr. Soc

      Volume: in press

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] 糖尿病治療を契機として有症状ビタミンB1欠乏症を発症した一例2013

    • Author(s)
      駒井絵里ら
    • Organizer
      第50回日本糖尿病学会関東甲信越地方会
    • Place of Presentation
      横浜
    • Year and Date
      2013-01-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎糸球体ポドサイトの炎症性障害に対するシロスタゾール/プロブコールの相加的保護作用2012

    • Author(s)
      賀鵬ら
    • Organizer
      第24回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 腎糸球体ポドサイトの炎症性障害に対するシロスタゾール/プロブコールの相加的保護作用2012

    • Author(s)
      賀鵬ら
    • Organizer
      第27回日本糖尿病合併症学会
    • Place of Presentation
      福岡
    • Year and Date
      2012-11-02
    • Related Report
      2012 Final Research Report
  • [Presentation] 高intact PTH血症を契機に発見されたビタミンD欠乏症の1例2012

    • Author(s)
      岩田裕子ら
    • Organizer
      第56回日本老年病学会関東甲信越地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-09-29
    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性腎障害に対するシロスタゾール/プロブコールの保護作用2012

    • Author(s)
      賀鵬ら
    • Organizer
      第44回日本動脈硬化学会総会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2012-07-19
    • Related Report
      2012 Final Research Report
  • [Presentation] ウェルナー症候群における糖尿病と悪性腫瘍の相関解析2012

    • Author(s)
      河村治清ら
    • Organizer
      日本内科学会第588回関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-06-09
    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性腎障害に対するシロスタゾール/プロブコールの保護作用2012

    • Author(s)
      賀鵬ら
    • Organizer
      第55回腎臓病学会
    • Place of Presentation
      横浜
    • Year and Date
      2012-06-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 2型糖尿病症例における血管内皮機能に影響を及ぼす因子の検討2012

    • Author(s)
      北本匠ら
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Year and Date
      2012-05-19
    • Related Report
      2012 Final Research Report
  • [Presentation] 我が国のウェルナー症候群患者における代謝異常および心血管疾患の解析2012

    • Author(s)
      河村治清ら
    • Organizer
      日本内科学会第587回関東地方会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-12
    • Related Report
      2012 Final Research Report
  • [Presentation] 我が国のウェルナー症候群患者における代謝異常および心血管疾患の解析

    • Author(s)
      河村 治清
    • Organizer
      日本内科学会 第587回関東地方会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 2型糖尿病症例における血管内皮機能に影響を及ぼす因子の検討

    • Author(s)
      北本 匠
    • Organizer
      第55回日本糖尿病学会年次学術集会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] 炎症性腎障害に対するシロスタゾール/プロブコールの保護作用

    • Author(s)
      賀 鵬
    • Organizer
      第55回腎臓病学会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Presentation] ウェルナー症候群における糖尿病と悪性腫瘍の相関解析

    • Author(s)
      河村 治清
    • Organizer
      日本内科学会 第588回関東地方会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 炎症性腎障害に対するシロスタゾール/プロブコールの保護作用

    • Author(s)
      賀 鵬
    • Organizer
      第44回 日本動脈硬化学会 総会 学術集会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高intact PTH血症を契機に発見されたビタミンD欠乏症の1例

    • Author(s)
      岩田 裕子
    • Organizer
      第56回 日本老年病学会関東甲信越地方会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腎糸球体ポドサイトの炎症性障害に対するシロスタゾール/プロブコールの相加的保護作用

    • Author(s)
      賀 鵬
    • Organizer
      第27回 日本糖尿病合併症学会
    • Place of Presentation
      福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 腎糸球体ポドサイトの炎症性障害に対するシロスタゾール/プロブコールの相加的保護作用

    • Author(s)
      賀 鵬
    • Organizer
      第24回日本糖尿病性腎症研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 糖尿病治療を契機として有症状ビタミンB1欠乏症を発症した一例

    • Author(s)
      駒井 絵里
    • Organizer
      第50回 日本糖尿病学会関東甲信越地方会
    • Place of Presentation
      横浜
    • Related Report
      2012 Annual Research Report
  • [Book] Modern Physician2012

    • Author(s)
      河村治清、横手幸太郎
    • Total Pages
      5
    • Publisher
      新興医学出版社
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Book] Modern Physician2012

    • Author(s)
      河村 治清
    • Total Pages
      5
    • Publisher
      新興医学出版社
    • Related Report
      2012 Annual Research Report
  • [Book] 糖尿病・代謝疾患の分指標的と治療薬辞典

    • Author(s)
      河村治清、横手幸太郎
    • Publisher
      羊土社、印刷中
    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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