analysis of transposable genes in the tumors of hypersensitive individuals

• Project/Area Number: 23790439
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Experimental pathology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: KURABE Nobuya 浜松医科大学, 医学部, 助教 (60466737)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ゲノム不安定性 / レトロトランスポゾン / LINE-1 / インバース PCR / 次世代シーケンサー / インバースPCR

Research Abstract

Genomic instability is one of the important regulatory mechanisms in the tumor development. The regulations of chromosome segregation and centrosome amplification are known to be involved in the genomic instability. Transposable genes “retrotransposons” are also implicated in it. In this study, although we used the more faster and high throughput technique compared with previous one, we could not find the tumor specific long interspersed element-1 (LINE-1, L1).