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analysis of transposable genes in the tumors of hypersensitive individuals

Research Project

Project/Area Number 23790439
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Experimental pathology
Research InstitutionHamamatsu University School of Medicine

Principal Investigator

KURABE Nobuya  浜松医科大学, 医学部, 助教 (60466737)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywordsゲノム不安定性 / レトロトランスポゾン / LINE-1 / インバース PCR / 次世代シーケンサー / インバースPCR
Research Abstract

Genomic instability is one of the important regulatory mechanisms in the tumor development. The regulations of chromosome segregation and centrosome amplification are known to be involved in the genomic instability. Transposable genes “retrotransposons” are also implicated in it. In this study, although we used the more faster and high throughput technique compared with previous one, we could not find the tumor specific long interspersed element-1 (LINE-1, L1).

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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