| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2013: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Research Abstract |
Mycoplasma pneumoniae induced pneumonia in human. Lipoproteins of M. pneumoniae and its receptor Toll-like Receptor (TLR) 2 were have been thought to be important to induce inflammation. However, in this study, we demonstrated that M. pneumoniae induced inflammatory responses through TLR2-independent pathway. TLR4 and autophagy played important roles in the induction of TLR2-independent pathway. Moreover, transposon mutagenesis revealed that cytadherence of M. pneumoniae was important factor for the induction. Overall, these results suggest that cytadherence of M. pneumoniae induces inflammatory responses through TLR4 and autophagy.
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