| Project/Area Number |
23790507
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Virology
|
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | RS ウイルス / hTERT 導入ヒト正常細胞 / 自然免疫 / RSウイルス / ｈTERT導入ヒト正常鼻細胞 / ｈＴＥＲＴ導入ヒト正常鼻粘膜上皮細胞 / IFN-lambda |
|---|
| Research Abstract |
We reported that IFN-λ is the predominant IFN induced from RSV infected nasal epithelial cells. However, there were no-significant difference between IFN-λand IFN-βin nasal discharge of RSV-infected child. Streptococcus pneumonia and chemokines in nasal discharge were detected. Humuleone, the main constituent of hop bitter acids, inhibited RSV replication and chemokines production, and Clarithromycis, antimicrobial agent, inhibited chemokines production and PAF expressioni, which is the receptor of S. pneumonia. These results suggested new treatment approach to RSV infection.
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