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Molecular basis of hematopoietic stem and progenitor niche formation

Research Project

Project/Area Number 23790533
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Immunology
Research InstitutionKyoto University

Principal Investigator

OMATSU Yoshiki  京都大学, 再生医科学研究所, 助教 (80437277)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsサイトカイン / 造血幹細胞ニッチ / ニッチ / 造血幹細胞 / ケモカイン / 骨髄
Research Abstract

We have shown that CXC chemokine ligand (CXCL)12-abundant reticular (CAR) cells have potential to differentiate into adipocytes and osteoblasts,and play an essential role in maintenance of hematopoietic stem and progenitor cells (HSPCs) in vivo, meeting the criteria for “niche”. However, themolecular basis of the formation of cellular niches remain unclear. In this study, we found several candidate genes that play essential roles for developmentand maintenance of CAR cells, using microarrayandqRT-PCR analysis, and we generated conditional knock-out mice of these genes.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (4 results)

All 2012 2011

All Journal Article (4 results) (of which Peer Reviewed: 4 results)

  • [Journal Article] Extracellul- ar matrix protein Tenascin-C is req- uired in the bone marrow microenvio- nment primed for hematopoietic rege- neration2012

    • Author(s)
      Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasa- wa T, Suda T, Kubota Y
    • Journal Title

      Blood

      Volume: 119 Issue: 23 Pages: 5429-5437

    • DOI

      10.1182/blood-2011-11-393645

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Control of hematopoietic stem cells by the bone marrow stromal niche : the role of reticular cells2011

    • Author(s)
      Nagasawa, T., Omatsu, Y., Sugiyama, T.
    • Journal Title

      Trends Immunol.

      Volume: 32 Issue: 7 Pages: 315-320

    • DOI

      10.1016/j.it.2011.03.009

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero2011

    • Author(s)
      Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T
    • Journal Title

      J Exp Med

      Volume: 208 Issue: 5 Pages: 949-960

    • DOI

      10.1084/jem.20102187

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero.2011

    • Author(s)
      Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H, Suda T.
    • Journal Title

      J. Exp. Med.

      Volume: 208(5) Pages: 949-960

    • Related Report
      2011 Research-status Report
    • Peer Reviewed

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Published: 2011-08-05   Modified: 2019-07-29  

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