Regulatory role of CRTAM+CD4+T cells in the mucosal immunity

• Project/Area Number: 23790551
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Immunology
• Research Institution: The Institute of Physical and Chemical Research
• Principal Investigator: TAKEUCHI Arata 独立行政法人理化学研究所, 統合生命医科学研究センター, 研究員 (00360579)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2012: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 細胞接着因子 / 細胞傷害活性 / 粘膜免疫 / 免疫学

Research Abstract

We previously identified an adhesion molecule CRTAM that is expressed on activated lymphocytes. Most of the T cells belong to one of two subset, these are CD8+ cytotoxic T cells and CD4+ helper T cells. In this study, we found that a small fraction of activated CD4+T cells express CRTAM. The gene expression profiles revealed that CRTAM+CD4+T cells shear both characteristics of helper and cytotoxic T cells. CRTAM+CD4+T cells are accumulated to intestine, and function during immune response. However, they worsen a symptom when colitis is induced.

Research Products

• [Presentation] CRTAM+CD4+T cells represent a lineage of CD4+ cells with CTL function (2013)
  • Author(s): 竹内新
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 幕張メッセ
  • Year and Date: 2013-12-12
• [Presentation] CRTAM expression regulates localization and differentiation of CD4+T cells in vivo (2012)
  • Author(s): 竹内新
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-07
• [Presentation] CRTAM陽性CD4+T細胞の生体内における機能 (2012)
  • Author(s): 竹内新
  • Organizer: 第22回Kyoto T cell Conference
  • Place of Presentation: 和順会館・京都
  • Year and Date: 2012-07-07
• [Presentation] CRTAM陽性CD4+T細胞の生体内における機能 (2012)
  • Author(s): 竹内 新
  • Organizer: Kyoto T cell Conference (KTCC)
  • Place of Presentation: 和順会館（京都）
• [Presentation] CRTAM expression regulates localization and differentiation of CD4+T cells in vivo. (2012)
  • Author(s): 竹内 新
  • Organizer: 日本免疫学会
  • Place of Presentation: 神戸国際会議場
• [Presentation] CRTAM+CD4+T cells represent a lineage of CD4+ cells with CTL function.
  • Author(s): 竹内新
  • Organizer: 日本免疫学会
  • Place of Presentation: 幕張メッセ（千葉）