| Project/Area Number |
23790553
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Immunology
|
|---|
| Research Institution | National Institute of Infectious Diseases |
|---|
Principal Investigator |
ONODERA Taishi 国立感染症研究所, 免疫部, 主任研究官 (90513143)
|
|---|
| Project Period (FY) |
2011 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | 記憶B細胞 / Toll様受容体 / ワクチン / インフルエンザウイルス / 免疫学 / ウイルス感染 / インフルエンザ / 記憶免疫応答 |
|---|
| Research Abstract |
Rapid production of high affinity antibodies by memory B cells, which are generated by prior vaccination and/or infection, plays an important role to improve mortality and morbidity in acute infectious diseases as influenza virus infection. In this study, we showed that memory B cells could produce high neutralizing antibodies against influenza virus more rapidly in CD4+ helper T cells independent way. Moreover, this reactivation mechanism was totally dependent upon B-cell intrinsic TLR7-MyD88 signaling, which is elicited by ssRNA included in virus particles. These findings provide insight into the new reactivating mechanisms of virus-specific memory B cells, together the development of new vaccine strategy to preferentially elicit high affinity antibodies from pre-existing memory B cell pool by booster vaccination.
|
