Elucidation of new reactivation mechanisms of influenza virus specific memory B cells in mouse model for influenza infection
Project/Area Number |
23790553
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Immunology
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Research Institution | National Institute of Infectious Diseases |
Principal Investigator |
ONODERA Taishi 国立感染症研究所, 免疫部, 主任研究官 (90513143)
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 記憶B細胞 / Toll様受容体 / ワクチン / インフルエンザウイルス / 免疫学 / ウイルス感染 / インフルエンザ / 記憶免疫応答 |
Research Abstract |
Rapid production of high affinity antibodies by memory B cells, which are generated by prior vaccination and/or infection, plays an important role to improve mortality and morbidity in acute infectious diseases as influenza virus infection. In this study, we showed that memory B cells could produce high neutralizing antibodies against influenza virus more rapidly in CD4+ helper T cells independent way. Moreover, this reactivation mechanism was totally dependent upon B-cell intrinsic TLR7-MyD88 signaling, which is elicited by ssRNA included in virus particles. These findings provide insight into the new reactivating mechanisms of virus-specific memory B cells, together the development of new vaccine strategy to preferentially elicit high affinity antibodies from pre-existing memory B cell pool by booster vaccination.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection2012
Author(s)
Onodera, T., Takahashi, Y., Yokoi, Y., Ato, M., Kodama, Y., Hachimura, S., Kurosaki, T., and Kobayashi, K
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Journal Title
Proc. Natl. Acad. Sci. U. S. A.
Volume: 109
Issue: 7
Pages: 2485-90
DOI
Related Report
Peer Reviewed
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[Presentation] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection2012
Author(s)
Takahashi, Y.Onodera, T., Yokoi, Y., Ato, M.,Hachimura, S., Kurosaki, T., Kobayashi, K
Organizer
Keystone symposia, Viral Immunity and Host Gene Influence
Place of Presentation
Colorado, USA
Year and Date
2012-03-25
Related Report
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[Presentation] Memory B cells in the lung participate in protective humoral immune responses to pulmonary influenza virus reinfection
Author(s)
Takahashi, Y.Onodera, T., Yokoi, Y., Ato, M., Hachimura, S., Kurosaki, T., Kobayashi, K.
Organizer
Keystone symposia, Viral Immunity and Host Gene Influence(招待講演)
Place of Presentation
Colorado, USA
Related Report
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