Individualized molecular targeted therapy based on pharmacogenomics and pharmacokinetic optimization
Project/Area Number |
23790597
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Applied pharmacology
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Research Institution | Kyoto University |
Principal Investigator |
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Project Period (FY) |
2011 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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Keywords | 分子標的治療薬 / 薬物動態 / 有効性 / 安全性 / ゲノム情報 / 個別最適投与 / 薬理ゲノム / 個別最適化 / 副作用 / 個別化投与設計 |
Research Abstract |
We demonstrated that plasma concentration of sorafenib was significantly higher in patients with renal cell carcinoma or hepatocellular carcinoma who developed grade 2 or higher hand-foot skin reaction as compared with those without the adverse event. Furthermore, the cumulative incidence of grade 3/4 adverse events was closely related with early drug exposure in lung cancer patients treated with erlotinib. These findings suggest that drug concentrations could be a useful predictor for avoiding adverse events induced by molecular targeted agents.
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Report
(3 results)
Research Products
(22 results)
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[Journal Article] Population pharmacokinetics/pharmacodynamics of erlotinib and pharmacogenomic analysis of plasma and cerebrospinal fluid drug concentrations in Japanese patients with non-small cell lung cancer.2013
Author(s)
Fukudo M, Ikemi Y, Togashi Y, Masago K, Kim YH, Mio T, Terada T, Teramukai S, Mishima M, Inui K, Katsura T.
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Journal Title
Clinical Pharmacokinetics
Volume: 52
Issue: 7
Pages: 593-609
DOI
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Peer Reviewed
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[Presentation] Population pharmacokinetics and pharmacogenomics of erlotinib: Impact of drug exposure on treatment outcomes in Japanese patients with non-small cell lung cancer2011
Author(s)
Fukudo M, Ikemi Y, Togashi Y, Masago K, Kim YH, Mio T, Mishima M, Inui K, Katsura T.
Organizer
2011 ASCO Annual Meeting
Place of Presentation
Chicago, IL, USA
Related Report
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