diagnostics development of unstableatherosclerosis based on new technology

• Project/Area Number: 23790600
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Okayama University
• Principal Investigator: OGAWA Hiroko 岡山大学, 岡山大学病院, 助教 (70423283)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2011: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: イメージング / 動脈硬化 / リポソーム

Research Abstract

Detection of vulnerable plaque is a promising strategy for atherosclerosis imaging. Vulnerable plaque is characterized by the infiltration of inflammatory cells. SLX-Lipo-statin attenuated the inflammation of atherosclerotic lesions in vivo, which was monitored non-invasively. We demonstrated that E-selectin-targeted liposomes can be a powerful tool for the detection of and the treatment for atheromatous plaques with the advantage of non-invasive and repeatable assessment.

Research Products

• [Journal Article] Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis (2012)
  • Author(s): Obika M, Ogawa H, Takahashi K, Li J, Hatipoglu OF, Cilek MZ, Miyoshi T,Inagaki J, Ohtsuki T, Kusachi S, Ninomiya Y, Hirohata S
  • Journal Title: Cancer Sci Volume: 103(10) Pages: 1889-97
  • NAID: 120005324789
  • Peer Reviewed
• [Journal Article] Tumor growth inhibitory effect of ADAMTS1 is accompanied by the inhibition of tumor angiogenesis. (2012)
  • Author(s): Obika M
  • Journal Title: Cancer Science Volume: 10 Issue: 10 Pages: 1889-1897
  • DOI: 10.1111/j.1349-7006.2012.02381.x
  • Peer Reviewed
• [Journal Article] Distribution pattern of urine albumin creatinine ratio and the prevalence of high-normal levels in untreated asymptomatic non-diabetic hypertensive patients (2011)
  • Author(s): Ohmaru N, Nakatsu T, Izumi R, Mashima K, Toki M, Kobayashi A, Ogawa H, Hirohata S, Ikeda S, Kusachi S
  • Journal Title: Intern Med Volume: 50(16) Pages: 1621-9
  • NAID: 130000969361
  • Peer Reviewed
• [Journal Article] Olmesartan reduces arterial stiffness and serum adipocyte fatty acid-binding protein in hypertensive patients (2011)
  • Author(s): Miyoshi T, Doi M, Hirohata S, Kamikawa S, Usui S, Ogawa H, Sakane K, Izumi R, Ninomiya Y, Kusachi S
  • Journal Title: Heart Vessels Volume: 26(4) Pages: 408-13
  • Peer Reviewed
• [Presentation] Impact of Collagen Gene Deficiency on the Intimal Hyperplasia after Angioplasty (2012)
  • Author(s): 小川弘子、廣畑聡、小比賀真就、幡中邦彦、伊藤浩、佐田政隆、草地省蔵
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡
  • Year and Date: 2012-03-18
• [Presentation] Impact of Collagen Gene Deficiency on the Intimal Hyperplasia after Angioplasty (2012)
  • Author(s): 小川 弘子
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡県博多市
• [Presentation] Impact of Fluorescent Imaging with E-selectin-targeted Liposome on Non-invasive Assessment of Therapeutic Effect for Atherosclerosis in Mice (2012)
  • Author(s): 幡中 邦彦
  • Organizer: 第76回日本循環器学会学術集会
  • Place of Presentation: 福岡県博多市
• [Presentation] 発作性心房細動の出現率に対するarterial stiffness増加の影響 (2011)
  • Author(s): 小川弘子、三好亨、土井正行、廣畑聡、草地省蔵、小出典男
  • Organizer: 第58回日本臨床検査医学会
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-19
• [Presentation] 虚血性心疾患患者によるCAVIと冠動脈硬化、左心機能の関連性の検討 (2011)
  • Author(s): 小川弘子、三好亨、土井正行、廣畑聡、草地省蔵、小出典男
  • Organizer: 第58回日本臨床検査医学会
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-19
• [Presentation] ARB内服中高血圧愚者に対するカルシウム拮抗薬もしくは利尿剤の追加がAugment indexへ与える影響 (2011)
  • Author(s): 三好亨、土井正行、小川弘子、廣畑聡、草地省蔵、小出典男、伊藤浩
  • Organizer: 第58回日本臨床検査医学会
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-19
• [Presentation] 非糖尿病性未治療高血圧患者におけるUACRの分布とhigh-normalの頻度 (2011)
  • Author(s): 小川弘子、大丸奈月、中津高明、泉礼司、間島圭一、土岐美沙子、小林亜紗子、廣畑聡、池田敏、草地省蔵
  • Organizer: 第58回日本臨床検査医学会
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-18
• [Presentation] 急性冠症候群患者における血清ADAMTS-1レベルの上昇 (2011)
  • Author(s): 廣畑聡、小比賀真就、幡中邦彦、小川弘子、三好亨、石井裕子、坂本かおり、草地省蔵、伊藤浩、二宮善文
  • Organizer: 第58回日本臨床検査医学会
  • Place of Presentation: 岡山
  • Year and Date: 2011-11-18
• [Presentation] The role of α556 chains of Type IV Collagen In Restenosis After Angioplasty (2011)
  • Author(s): Hiroko Ogawa, Tomoko Yonezawa, Masataka Sata, Satoshi Hirohata, Toshitaka Oohashi, Shozo Kusachi, Norio Koide, Yoshifumi Ninomiya
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-16
• [Presentation] Neurocan-GFP, a novel probe for hyaluronan in atherosclerotic plaques (2011)
  • Author(s): Natsuki Ohmaru, HIroko Ogawa, Toshitaka Oohashi, Rauch Uwe, Yoshifumi NIinomiya, Shozo Kusachi
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-16
• [Presentation] Endothelial cell-specific Early lmmediate Response Gene Expression in Hypoxia (2011)
  • Author(s): Satoshi Hirohata, Cilek Mehmet, Masanari Obika, Hiroko Ogawa, Hatipoglu Faruk, Toru MIyoshi, Shozo Kusachi, Yoshifumi Niinomiya
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-07-15
• [Presentation] The Role of α556 Chains of Type IV Collagen In Restenosis After Angioplasty (2011)
  • Author(s): 小川 弘子
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 北海道札幌市
• [Presentation] Neurocan-GFP, a novel probe for hyaluronan in atherosclerotic plaques (2011)
  • Author(s): 大丸 奈月
  • Organizer: 第43回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 北海道札幌市
• [Remarks]
  • URL: http://okayama-u-sougounaika.jp/