Molecular mechanism for sustention of placental function by ezrinand a new approach to prevention of fetal growth retardation

• Project/Area Number: 23790606
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Applied pharmacology
• Research Institution: Keio University
• Principal Investigator: KOSE Noriko 慶應義塾大学, 薬学部, 研究員 (60348612)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
• Keywords: 薬物代謝酵素 / トランスポーター / 血液胎盤関門 / 胎児成長 / エズリン / ヒポタウリン / 胎盤関門

Research Abstract

We analyzed the mechanisms of hypotaurine deficiency in the placenta of ezrin (Vil2) gene knockout mouse which shows fetal growth retardation. The results indicate that hypotaurine concentration in the placenta is mainly supplied by membrane transport

Research Products

• [Journal Article] Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes. (2012)
  • Author(s): Nishimura T, Chishu T, Tomi M, Nakamura R, Sato K, Kose N, Sai Y, Nakashima E
  • Journal Title: Drug Metab Pharmacokinet Volume: 27(4) Pages: 439-46
  • NAID: 130004463266
• [Journal Article] Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate (2011)
  • Author(s): Nishimura T, Tanaka J, Tomi M, Seki Y, Kose N, Sai Y, Nakashima E.
  • Journal Title: J Pharm Sci Volume: 100 Issue: 9 Pages: 3959-3967
  • DOI: 10.1002/jps.22624
  • Peer Reviewed
• [Presentation] (2012)
  • Author(s): Sugita Y, Higuchi K, Kamata K, Nishimura T, Kose N, Sai Y, Tomi M, Nakashima E
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: Tokyo Japan
• [Presentation] (2012)
  • Author(s): Duereh M, Higuchi K, Nishimura T, Kose N, Tomi M, Nakashima E
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: Tokyo Japan
• [Presentation] Increase of placental Slc6a13 expression and hypotaurine concentration at E12. (2012)
  • Author(s): Sugita Y, Higuchi K, Kamata K, Nishimura T, Kose N, Sai Y, Tomi M, Nakashima E.
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: 一橋記念講堂（東京都）
• [Presentation] Antioxidant effect of hypotaurine, a substrate for Sic6a13/ezrin complex, in the placenta. (2012)
  • Author(s): Duereh M, Higuchi K, Nishimura T, Kose N, Tomi M, Nakashima E.
  • Organizer: International Symposium on Past, Present and Future of Molecular Pharmacokinetics
  • Place of Presentation: 一橋記念講堂（東京都）
• [Presentation] (2011)
  • Author(s): Asada T, Takanohashi T, Nishimura T, Kose N, Tomi M, Nakashima E.
  • Organizer: 26th JSSX Annual Meeting
  • Place of Presentation: Hiroshima Japan
• [Presentation] (2011)
  • Author(s): Sugita Y, Higuchi K, Kamata K, Nishimura T, Kose N, Sai Y, Tomi M, Nakashima E
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Kuala Lumpur Malaysia
• [Presentation] (2011)
  • Author(s): Oda K, Nishimura T, Kose N, Tomi M, Nakashima E
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Kuala Lumpur Malaysia
• [Presentation] (2011)
  • Author(s): Duereh M, Nishimura T, Sugita Y, Kose N, Tomi M, Nakashima E
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Kuala Lumpur Malaysia
• [Presentation] (2011)
  • Author(s): 西村友宏, 田中純, 登美斉俊, 巨勢典子, 中島恵美
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: 東京
• [Presentation] (2011)
  • Author(s): 小田憲司, 西村友宏, 巨勢典子, 登美斉俊, 中島恵美
  • Organizer: 日本薬剤学会第26年会
  • Place of Presentation: 東京
• [Presentation] (2011)
  • Author(s): 杉田友紀, 鎌田可奈子, 西村友宏, 巨勢典子, 崔 吉道, 登美斉俊, 中島恵美
  • Organizer: 第6回トランスポーター研究会年仙台
  • Place of Presentation: 仙台
• [Presentation] (2011)
  • Author(s): 小田憲司, 西村友宏, 巨勢典子, 登美斉俊, 中島恵美
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 仙台
• [Presentation] (2011)
  • Author(s): Mariam Duereh、西村友宏、巨勢典子、登美斉俊、中島恵美
  • Organizer: 第55回日本薬学会関東支部大会
  • Place of Presentation: 船橋
• [Presentation] Relationship between hypotaurine concentration and expression levels of EZRIN and SLC6A13 shinnotransporter in mice placenta during pregnancy. (2011)
  • Author(s): Sugita Y, Higuchi K, Kamata K, Nishimura T, Kose N, Sai Y, Tomi M, Nakashima E.
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Renaissance Hotel Kuala Lumpur (Kuala Lumpur, Malaysia)
• [Presentation] Protecting effect of hypotaurine from hydrogen peroxide induced cytotoxicity in placental trophoblast cells. (2011)
  • Author(s): Duereh M, Nishimura T, Sugita Y, Kose N, Tomi M, Nakashima E.
  • Organizer: Asian Federation for Pharmaceutical Sciences 2011
  • Place of Presentation: Renaissance Hotel Kuala Lumpur (Kuala Lumpur, Malaysia)
• [Presentation] 妊娠経過に伴うマウス胎盤ezrinおよびSlc6a13の発現量推移とhypotaurine濃度への影響. (2011)
  • Author(s): 杉田友紀, 鎌田可奈子, 西村友宏, 巨勢典子, 崔 吉道, 登美斉俊, 中島恵美.
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 東北大学（宮城県仙台市）
• [Presentation] 酸化ストレスからのhypotaurineによる胎盤細胞保護効果. (2011)
  • Author(s): Mariam Duereh、西村友宏、巨勢典子、登美斉俊、中島恵美.
  • Organizer: 第6回トランスポーター研究会年会
  • Place of Presentation: 東北大学（宮城県仙台市）
• [Presentation] 胎盤におけるGABAトランスポーターの発現とヒポタウリン輸送能. (2011)
  • Author(s): 樋口慧、鎌田可奈子、西村友宏、巨勢典子、登美斉俊、崔吉道、中島恵美.
  • Organizer: 日光シンポジウム
  • Place of Presentation: 日光東照宮晃陽苑（栃木県日光市）