Roles of TRP channels expressed in immune and glial cells in chronic pain
| Project/Area Number |
23790641
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pain science
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KANEKO Shuji 京都大学, 大学院・薬学研究科, 教授 (60177516)
SHIRAKAWA Hisashi 京都大学, 大学院・薬学研究科, 助教 (50402798)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 疼痛の発生・増強機序 / 神経障害性疼痛 / TRP チャネル / TRPM2 / 免疫系細胞 / グリア細胞 / 脊髄 / 中枢性感作 / 慢性疼痛 / ミクログリア / マクロファージ / 神経炎症応答 / TRPC3 / アストロサイト / TRPV4 |
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| Research Abstract |
Chronic pain, such as peripheral nerve injury-induced neuropathic pain, is based on both peripheral and central sensitization, which is caused by neuroinflammation mediated by the interaction between peripheral/spinal neurons and immune/glial cells. In this research, we found that transient receptor potential (TRP) channels expressed in immune/glial cells play an important role in chronic pain. Especially, we examined the roles of TRPM2, which acts as a sensor for reactive oxygen species (ROS) in macrophages and microglia, in inflammatory and neuropathic pain in mice
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Report
(3 results)
Research Products
(119 results)
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[Journal Article] Stimulation of transient receptor potential vanilloid 4 channel suppresses abnormal activation of microglia induced by lipopolysaccharide2012
Author(s)
Konno M, Shirakawa H, lida S, Sakimoto S, Matsutani I, Miyake T,Kageyama K, Nakagawa T, Shibasaki K, Kaneko, S.
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Journal Title
Glia
Volume: 60
Issue: 5
Pages: 761-770
DOI
Related Report
Peer Reviewed
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[Presentation] Functional coupling of TRPC1 and TRPC3 in thrombin-induced astrocyte activation2011
Author(s)
Shirakawa, H., Konno, M., Munakata, M., Sakimoto, S., Nakagawa, T., Kaneko, S.
Organizer
Neuroscience2011 (the 41th Annual Meeting of the Society for Neuroscience)
Place of Presentation
Washington, DC (USA)
Related Report
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[Presentation] Stimulation of TRPV4 channel suppresses aberrant activation of microglia induced by lipopolisaccharide2011
Author(s)
Konno, M., Shirakawa, H., Iida, S., Sakimoto, S., Nakagawa, T., Shibasaki, K., Kaneko, S.
Organizer
The 6th SKO Symposium
Place of Presentation
ソウル（韓国）
Related Report
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[Presentation] Involvement of TRPM2 channel in mechanisms underlying microglial activation2011
Author(s)
Shirakawa, H., Kusano, A., Miyake, T., Konno, M., Nakagawa, T., Kaneko, S.
Organizer
第34回日本神経科学大会
Place of Presentation
パシフィコ横浜（神奈川県）
Related Report
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