| Project/Area Number |
23790669
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Hygiene
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| Research Institution | Kyoto Prefectural University of Medicine |
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Principal Investigator |
YOGOSAWA Shingo 京都府立医科大学, 医学研究科, 助教 (70381936)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 予防医学 / 食品成分 / 癌予防 / 細胞増殖シグナル伝達系 / 細胞周期 / シグナル伝達経路 / MEK-ERK経路 / PI3K-AKT経路 / CDK阻害因子 |
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| Research Abstract |
MEK-ERK or PI3K-Akt signal transduction pathways are accelerated in many cancers and considered to be the very important molecular targets not only for the cancer therapy but also for the cancer prevention. To develop a novel strategy for cancer prevention targeting the major signal transduction pathways associated with carcinogenesis by food constituents, growth inhibitory effect of brassinin ordehydrozingerone on human colon cancer cells was studied and the molecular mechanisms were analyzed. Brassinin, derived from cruciferous vegetables like cabbage or broccoli, repressed the growth of human colon cancer HT -29 cells mediated by inhibition of PI3K-Akt pathway . Dehydrozingerone, derived from a ginger, and is known as a structural half analogue of curcumin, which is known to inhibit MEK-ERK pathway. Dehydrozingerone repressed the growth of HT -29 cells in association with accumulation of intracellular reactive oxygen species (ROS). In addition, combination of a PI3K inhibitor with histone deacetylase inhibitor was shown to be useful for growth inhibition of human endometrial carcinoma HEC-1A cells.
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