Search for markers to monitor an effect of asbestos on CTL functions

• Project/Area Number: 23790679
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hygiene
• Research Institution: Kawasaki Medical School
• Principal Investigator: TAKEI Naoko 川崎医科大学, 医学部, 助教 (00509276)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2011: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
• Keywords: 石綿 / 中皮腫 / 胸膜プラーク / CTL / CD8

Research Abstract

We examined the effect of asbestos exposure on functions of CTL. Asbestos exposure showed the suppressed proliferation of CD8+ lymphocytes and the decreased cytotoxicity exerted by CD8+ T cells. Moreover, mesothelioma patients showedthe enhanced decrease in the percentage of perforin+ cells of stimulated CD8+ cells.

Research Products

• [Journal Article] Effect of Asbestos Exposure on Differentiation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Reaction of Human Peripheral Blood Mononuclear Cells. (2013)
  • Author(s): Kumagai-Takei N, Nishimura Y, Maeda M, Hayashi H, Matsuzaki H, Lee S, Hiratsuka J, and Otsuki T.
  • Journal Title: Am J Respir Cell Mol Biol Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] Effect of Asbestos Exposure on Differentiation of Cytotoxic T Lymphocytes in Mixed Lymphocyte Reaction of Human Peripheral Blood Mononuclear Cells. (2013)
  • Author(s): Naoko Kumagai-Takei
  • Journal Title: AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY Volume: -
  • Peer Reviewed
• [Journal Article] Asbestos induces reduction of tumor immunity. (2011)
  • Author(s): Kumagai-Takei N, Maeda M, Chen Y, Mastuzaki H, Lee S, Nishimura Y, Hiratsuka J, Otsuki T
  • Journal Title: Clin Devl Immunol Volume: 2011 Pages: 481439-481439
  • Peer Reviewed
• [Presentation] Difference in functional property of CD8+ lymphocytes between patients with pleural plaque and malignant mesothelioma (2013)
  • Author(s): Kumagai-Takei N, Nishimura Y, Maeda M, Matsuzaki H, Lee S, Kishimoto T, Fukuoka K, Nakano T, Otsuki T.
  • Organizer: 51th Annual Meeting of the Society of Toxicology
  • Place of Presentation: San Antonio, TX
  • Year and Date: 2013-03-11
• [Presentation] CD8+リンパ球に注目した胸膜プラーク陽性者と悪性中皮腫患者の免疫学的特徴 (2013)
  • Author(s): 武井直子,西村泰光,前田恵,林宏明,松崎秀紀,李順姫,岸本卓巳,福岡和也,中野孝司,大槻剛巳.
  • Organizer: 第12回分子予防環境医学研究会
  • Place of Presentation: 筑波
  • Year and Date: 2013-02-01
• [Presentation] IFN-γ production and cytotoxicity of CD8+ lymphocytes in patients with pleural plaque or malignant mesothelioma (2012)
  • Author(s): Kumagai-Takei N, Nishimura Y, Maeda M, Matsuzaki H, Lee S, Otsuki T.
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
  • Year and Date: 2012-12-07
• [Presentation] 胸膜プラーク陽性者と悪性中皮腫患者のCD8+リンパ球の機能解析 (2012)
  • Author(s): 武井直子,西村泰光,松崎秀紀,李順姫,大槻剛巳
  • Organizer: 第19回日本免疫毒性学会
  • Place of Presentation: 東京
  • Year and Date: 2012-09-16
• [Presentation] Effects of asbestos exposure on induction of cytotoxic T lymphocytes in mixed lymphocyte reactions and cytotoxic potential of CD8+ lymphocytes in asbestos-exposed people (2012)
  • Author(s): Kumagai-Takei N, Nishimura Y, Maeda M, Hayashi H, Matsuzaki H, Lee S, Kishimoto T, Otsuki T.
  • Organizer: The 30st International Commission on Occupational Health
  • Place of Presentation: Cancun,Mexico
  • Year and Date: 2012-03-19
• [Presentation] IFN-γ, granzyme B and perforin-positive cells of CD8+ lymphocytes in asbestos-exposed people with pleural plaque (2012)
  • Author(s): Kumagai-Takei N, Nishimura Y, Maeda M, Matsuzaki H, Lee S, Kishimoto T, Otsuki T.
  • Organizer: 51th Annual Meeting of the Society of Toxicology
  • Place of Presentation: San Francisco, CA
  • Year and Date: 2012-03-13
• [Presentation] 胸膜プラーク陽性石綿曝露者の末梢血CD8+リンパ球の機能評価 (2011)
  • Author(s): 武井直子,西村泰光,前田真組,松崎秀紀,李順姫,岸本卓巳,大槻剛巳
  • Organizer: 第55回中国四国合同産業衛生学会
  • Place of Presentation: 高知
  • Year and Date: 2011-12-11
• [Presentation] IFN-γ production and cytotoxicity of CD8+ lymphocytes in asbestos-exposed people with pleural plaque (2011)
  • Author(s): Kumagai N, Nishimura Y, Maeda M, Matsuzaki H, Lee S, Otsuki T
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
  • Year and Date: 2011-11-27
• [Presentation] ヒトCTL分化における石綿曝露影響および胸膜プラーク陽性者のCD8+Tリンパ球のIFNγ産生能 (2011)
  • Author(s): 熊谷直子,西村泰光,前田恵,松崎秀紀,李順姫,岸本卓巳,大槻剛巳
  • Organizer: がん予防大会2011京都
  • Place of Presentation: 京都
  • Year and Date: 2011-06-21
• [Presentation] 胸膜プラーク陽性者と悪性中皮腫患者のCD8+リンパ球の機能解析
  • Author(s): 武井直子
  • Organizer: 第19回 日本免疫毒性学会
  • Place of Presentation: 東京慈恵会医科大学大学 (東京)
• [Presentation] IFN-gamma production and cytotoxicity of CD8+ lymphocytes in patients with pleural plaque or malignant mesothelioma
  • Author(s): Naoko Kumagai-Takei
  • Organizer: 第41回 日本免疫学会学術集会
  • Place of Presentation: 神戸国際展示場 （神戸）
• [Presentation] CD8+リンパ球に注目した胸膜プラーク陽性者と悪性中皮腫患者の免疫学的特徴
  • Author(s): 武井 直子
  • Organizer: 第12回 分子予防環境医学研究会
  • Place of Presentation: つくばサイエンス・インフォメーションセンター （筑波）
• [Presentation] Difference in functional property of CD8+ lymphocytes between patients with pleural plaque and malignant mesothelioma
  • Author(s): Naoko Kumagai-Takei
  • Organizer: The 52st Annual meeting of Society of Toxicology
  • Place of Presentation: Henry B. Gonzalez Convention Center (San Antonio, TX, USA)
• [Presentation] IFN-gamma, granzyme B and perforin-positive cells of CD8+ lymphocytes in asbestos-exposed people with pleural plaque
  • Author(s): Naoko Kumagai-Takei
  • Organizer: The 51st Annnul meeting of Society of Toxicology
  • Place of Presentation: Moscone Convention Center (San Francisco, CA, USA)
• [Presentation] Effects of asbestos exposure on induction of cytotoxic T lymphocytes in mixed lymphocyte reactions and cytotoxic potential of CD8+ lymphocytes in asbestos-exposed people
  • Author(s): Naoko Kumagai
  • Organizer: The 30st International Commission on Occupational Health
  • Place of Presentation: Cancun Center (Cancun, Mexico)