| Project/Area Number |
23790752
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General internal medicine (including Psychosomatic medicine)
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| Research Institution | Kitasato University |
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Principal Investigator |
ENDO Mari 北里大学, 東洋医学総合研究所, 上級研究員 (60296829)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 東洋医学 / 呼気試験 / 潰瘍性大腸炎 / 漢方薬 / DSS マウス大腸炎 / 13C 酪酸 / 内科 / マウス大腸炎 / 酪酸 / 内科学一般 / DSSマウス大腸炎 / 13C酪酸 |
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| Research Abstract |
In this study, we showed for the first time that 13C-butyrate breath-test is well correlated with parameters commonly used for assessing inflammatory phase of Dextran sodium sulphate (DSS)-induced murine colitis. Because excretion of 13CO2in trinitoro benzene sulfonic acid (TNBS)-induced murine colitis was significantly lower than those of the normal mice, we confirmed that various types of murine colitis could be assessed by 13C-butyrate breath-test. Moreover, we have demonstrated the recovery of 13CO2excretion after the administration of Kampo medicine. Our data suggest that 13C-butyrate breath-test might reflect therapeutic efficacy of Kampo medicine in DSS-murine colitis. In conclusion, 13C-butyrate breath-test is newly established, non-invasive method for assessing murine colitis. It may provide real-time information on colonic inflammation, so it may be a useful tool in research on experimental colitis.
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