The multifactorial analysis and regulation of the immune evasion in viral-related hepatocellular carcinoma

• Project/Area Number: 23790761
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Tohoku University
• Principal Investigator: KONDO Yasuteru 東北大学, 病院, 助教 (70455822)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: HBV / HCC / ケモカイン / NK Cell / T Cell / CX3CL1 / HCV / Tregs / NKG2D / NK cell / T cell

Research Abstract

HBV-HCV viral interaction was occurred with immune cells. HCV-Core antigen could directly suppress the immune response. The expression patterns of chemokine were different among the various HBV genotypes. Among them, the expression level of CX3CL1 and the migration activity of NK cells were significantly different among HBV-genotypes. Moreover, the expression of NKG2D on the migrated NK cells was suppressed.

Research Products

• [Journal Article] Eradication ofhepatitis C virus (HCV) could improve the immunological status and pyoderma gangrenosum-like lesion (2013)
  • Author(s): Kondo Y, Iwata T, Haga T, Kimura O, Ninomiya M, Kakazu E, Kogure T, Morosawa T, Aiba S, Shimosegawa T.
  • Journal Title: Hepatology Research Volume: 44 Issue: 2 Pages: 4-4
  • DOI: 10.1111/hepr.12102
  • Peer Reviewed
• [Journal Article] PPARs and Liver Diseases (2013)
  • Author(s): Kondo Y, Uno K, Machida K and Terajima M
  • Journal Title: PPAR Research Volume: 2013 Pages: 896412-896412
  • Peer Reviewed
• [Journal Article] Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection. (2013)
  • Author(s): Yasuteru Kondo et al.
  • Journal Title: ISRN Gastroenterol. Volume: 2013:935295 Pages: 935295-935295
  • DOI: 10.1155/2013/935295
  • Peer Reviewed
• [Journal Article] Murine models of non-alcoholic fatty liver disease and steatohepatitis (2013)
  • Author(s): Ninomiya M, Kondo Y, Shimosegawa T
  • Journal Title: ISRN Hepatology Volume
  • URL: http://dx.doi.org/10.1155/2013/237870
  • Peer Reviewed
• [Journal Article] PPARs and Liver Disease. (2013)
  • Author(s): Yasuteru Kondo et al.
  • Journal Title: PPAR Res. Volume: 2013:896412 Pages: 1-2
  • DOI: 10.1155/2013/896412
  • Peer Reviewed
• [Journal Article] PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma. (2012)
  • Author(s): Osamu Kimura et al.
  • Journal Title: PPAR Res. Volume: 2012(574180) Pages: 574180-574180
  • DOI: 10.1155/2012/574180
  • Peer Reviewed
• [Journal Article] Relationship between renal dysfunction and abnormalities of the immune system in patients with decompensated cirrhosis (2012)
  • Author(s): Kakazu E, Kondo Y, Shimosegawa T
  • Journal Title: ISRN Gastroenterology Volume: 2012 Pages: 123826-123826
  • DOI: 10.5402/2012/123826
  • Peer Reviewed
• [Journal Article] Double filtration plasmapheresis could induce a favorable immune response for chronic hepatitis C therapy. (2012)
  • Author(s): Yasuteru Kondo et al.
  • Journal Title: Ther Apher Dial. Volume: 16(5) Issue: 5 Pages: 478-479
  • DOI: 10.1111/j.1744-9987.2012.01113.x
  • Peer Reviewed
• [Journal Article] Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis. (2012)
  • Author(s): Jun Inoue et al.
  • Journal Title: J Clin Virol. Volume: 55(2) Issue: 2 Pages: 147-152
  • DOI: 10.1016/j.jcv.2012.06.011
  • Peer Reviewed
• [Journal Article] The influence of pioglitazone on the plasma amino acids profile in patients with Nonalcoholic Steatohepatitis (NASH) (2012)
  • Author(s): Kakazu E, Kondo Y, Ninomiya M, Kimura O, Nagasaki F, Ueno Y, Shimosegawa T.
  • Journal Title: Hepatology International Volume: 2012 Issue: 2 Pages: 577-585
  • DOI: 10.1007/s12072-012-9395-y
  • Peer Reviewed
• [Journal Article] Sequential Immunological Analysis of HBV/HCV Co-Infected Patients During (2012)
  • Author(s): Kondo Y, Ueno Y, Ninomiya M, Tamai K, Tanaka Y, Inoue J, Kakazu E, Kobayashi K, Shimosegawa T
  • Journal Title: Peg-IFN/RBV therapy J Gastroenterol Volume: 47(12) Issue: 12 Pages: 1323-35
  • DOI: 10.1007/s00535-012-0596-x
  • Peer Reviewed
• [Journal Article] Biological Significance of HCV in various kinds of lymphoid cells (2012)
  • Author(s): Kondo Y, Ueno Y, Shimosegawa T.
  • Journal Title: International Journal of Microbiology Volume: 2012 Pages: 1-7
  • DOI: 10.1155/2012/647581
  • Peer Reviewed
• [Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants (2012)
  • Author(s): Ninomiya M, Ueno Y, Funayama R, Kagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
  • Journal Title: Journal of clinical microbiology Volume: 50 Issue: 3 Pages: 857-866
  • DOI: 10.1128/jcm.05715-11
  • Peer Reviewed
• [Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway (2012)
  • Author(s): Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue Fukushima K, Sano K, Ueno Y, Shimosegawa T
  • Journal Title: Virology Volume: 20;422(2) Pages: 377-85
  • Peer Reviewed
• [Journal Article] Sequential Immunological Analysis of HBV/HCV Co-Infected Patients During Peg-IFN/RBV therapy (2012)
  • Author(s): Yasuteru Kondo et al.
  • Journal Title: Journal of Gastroenterology Volume: -
  • NAID: 10031145519
  • Peer Reviewed
• [Journal Article] Rapid Reduction of HCV-Core protein in the peripheral blood improve the immunological response in ChronicHepatitis (2011)
  • Author(s): Kondo Y, Ueno Y, Wakui Y, Ninomiya M, Kakazu E, Inoue J, Kobayashi K, Obara N, Shimosegawa T
  • Journal Title: C patients Hepatol Res Volume: 41(12) Pages: 1153-68
  • Peer Reviewed
• [Journal Article] Toll Like Receptors (TLRs) Signaling Contribute to Immunopathogenesis of HBV Infection (2011)
  • Author(s): Kondo Y, Ueno Y, Shimosegawa T.
  • Journal Title: Gastroenterol Res Pract Volume: 2011 Pages: 810939-810939
  • DOI: 10.1155/2011/810939
  • Peer Reviewed
• [Journal Article] Dysfunction of Immune Systems and HostGenetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT (2011)
  • Author(s): Kondo Y, Ueno Y, Shimosegawa T.
  • Journal Title: Hepatitis Research and Treatment Volume: 2011 Pages: 1-7
  • DOI: 10.1155/2011/713216
  • Peer Reviewed
• [Journal Article] Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+circulating monocytes in patients with advanced cirrhosis (2011)
  • Author(s): E. Kakazu, Y. Ueno, Y. Kondo, J. Inoue, M. Ninomiya, O. Kimura, Y. Wakui, K. Fukushima, K. Tamai, T. Shimosegawa
  • Journal Title: PLoS One Volume: 6 Issue: 8 Pages: 23402-23402
  • DOI: 10.1371/journal.pone.0023402
  • Peer Reviewed
• [Journal Article] Enhanced Replication of Hepatitis B Virus with Frameshift in the Precore Region Found in Fulminant Hepatitis Patients (2011)
  • Author(s): Inoue J, Ueno Y, Wakui Y, Fukushima K, Kondo Y, Kakazu E, Ninomiya M, Niitsuma H,Shimosegawa T.
  • Journal Title: J Infect Dis Volume: 1;204(7) Pages: 1017-25
  • Peer Reviewed
• [Journal Article] B型肝炎ウイルス制御のための病態解析 (2011)
  • Author(s): 近藤泰輝、上野義之、下瀬川徹
  • Journal Title: 消化器と免疫(48) Pages: 62-65
• [Journal Article] C型肝炎のすべて2012:症例に応じたDAA治療時期の選択 (2011)
  • Author(s): 近藤泰輝、上野義之、下瀬川徹
  • Journal Title: 肝胆膵 Volume: 63(6) Pages: 1255-1260
• [Journal Article] Rapid Reduction of HCV-Core protein in the peripheral blood improve the immunological response in Chronic Hepatitis C patients (2011)
  • Author(s): Yasuteru Kondo, Yoshiyuki Ueno, Yuta Wakui et al.
  • Journal Title: Hepatology Research Volume: 41(12) Issue: 12 Pages: 1153-1168
  • DOI: 10.1111/j.1872-034x.2011.00878.x
  • Peer Reviewed
• [Journal Article] TheNutritional Index 'CONUT' Is Useful for Predicting Long-Term Prognosis of Patients with End-Stage Liver Diseases
  • Author(s): Fukushima K, Ueno Y, Kawagishi N, Kondo Y, Inoue J, Kakazu E, Ninomiya M, Wakui Y, Saito N, Satomi S, Shimosegawa T.
  • Journal Title: Tohoku J Exp Med Volume: 224(3) Pages: 215-9
  • Peer Reviewed
• [Presentation] シンポジウムHBV持続感染患者における免疫抑制のメカニズムとETV-IFNSequential療法中における経時的免疫解析 (2012)
  • Author(s): 近藤泰輝, 他
  • Organizer: 日本肝臓学会東部会
  • Place of Presentation: 東京
  • Year and Date: 2012-12-07
• [Presentation] Vitamin D3 supplementation could improve the sensitivity of immune-response during (2012)
  • Author(s): Kondo Y et al
  • Organizer: Peg-IFN/RBV therapy in chronic hepatitis C patients 10th STC-JSH 2012 Young Investigator Award
  • Place of Presentation: 東京
  • Year and Date: 2012-11-22
• [Presentation] HBV-related hepatocellular carcinoma could express CX3CL1 and affect the migration of NKG2DlowCX3CR1+NK cells (2012)
  • Author(s): Kondo Y, et al
  • Organizer: AASLD 2012 Annual Meeting
  • Place of Presentation: ボストン、アメ リカ
  • Year and Date: 2012-11-10
• [Presentation] Detection of a new genotype 1b lymphotropic HCV strain andanalysis of Th17 commitment (2012)
  • Author(s): Kondo Y, et al
  • Organizer: AASLD 2012Annual Meeting
  • Place of Presentation: ボストン、アメリカ
  • Year and Date: 2012-11-10
• [Presentation] パネルディスカッションTh17分化誘導によるHCV関連自己免疫疾患発症の可能性 (2012)
  • Author(s): 近藤泰輝, 他
  • Organizer: 日本肝臓学会大会JDDW
  • Place of Presentation: 神戸
  • Year and Date: 2012-10-11
• [Presentation] IL28B,ITPA polymorphismとVitamin D濃度からみた肝移植後C型肝炎治療今後の可能性 (2012)
  • Author(s): 近藤泰輝, 他
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2012-06-07
• [Presentation] HBV関連肝細胞癌より放出される液性因子は免疫細胞浸潤能、活性化に影響を与えるワークショップ (2012)
  • Author(s): 近藤泰輝, 他
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2012-06-07
• [Presentation] Vitamin D3製剤併用Peg-IFN/RBV治療の成績(多施設共同研究)オープンワークショップ (2012)
  • Author(s): 近藤泰輝, 他
  • Organizer: 48回日本肝臓学会総会
  • Place of Presentation: 金沢
  • Year and Date: 2012-06-07
• [Presentation] Rapid Reduction of HCV-core Protein in the peripheral Blood induces Favorable Effect in Treatment ofChronic Hepatitis C Patients (2012)
  • Author(s): Kondo Y, et al
  • Organizer: IF-Best Poster Award Presentation in the 3rd International Forum JSGE
  • Place of Presentation: 東京
  • Year and Date: 2012-04-20
• [Presentation] The CX3CL1 produced fromHBV-replicated human hepatoma cells could affect the migration activity of lymphoid cells (2012)
  • Author(s): Kondo Y, et al
  • Organizer: APASL 2012 Annual Meeting
  • Place of Presentation: 台北台湾
  • Year and Date: 2012-02-17
• [Presentation] Rapid Reduction of HCV-Core protein in the peripheral blood induces favorable effect in treatment of Chronic Hepatitis C patients (2012)
  • Author(s): Yasuteru Kondo
  • Organizer: 日本消化器病学会総会
  • Place of Presentation: 東京
• [Presentation] ワークショップ 肝細胞癌に対する免疫の基礎と治療への展開 HBV関連肝細胞癌より放出される液性因子は免疫細胞浸潤能、活性化に影響を与える (2012)
  • Author(s): 近藤泰輝
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] Vitamin D3製剤併用Peg-IFN/RBV治療の成績（多施設共同研究） (2012)
  • Author(s): 近藤泰輝
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] IL28B, ITPA polymorphismとVitamin D濃度からみた肝移植後C型肝炎治療今後の可能性 (2012)
  • Author(s): 近藤泰輝
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 金沢
• [Presentation] パネルディスカッション：ウイルス性肝炎と肝外病変 Th17分化誘導によるHCV関連自己免疫疾患発症の可能性 (2012)
  • Author(s): 近藤泰輝
  • Organizer: JDDW
  • Place of Presentation: 神戸
• [Presentation] Detection of a new genotype 1b lymphotropic HCV strain and the analysis of Th17 commitment. (2012)
  • Author(s): Yasuteru Kondo
  • Organizer: AASLD Annual Meeting
  • Place of Presentation: ボストン、アメリカ
• [Presentation] HBV-related hepatocellular carcinoma could express CX3CL1 and affect the migration of NKG2DlowCX3CR1+NK cells (2012)
  • Author(s): Yasuteru Kondo
  • Organizer: AASLD Annual Meeting
  • Place of Presentation: ボストン、アメリカ
• [Presentation] Distinguished Presentation: Vitamin D3 supplementation could improve the sensitivity of immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients (2012)
  • Author(s): Yasuteru Kondo
  • Organizer: The 10th JSH Single Topic Conference “Hepatitis C: Best Practice Based on Science”
  • Place of Presentation: 東京
• [Presentation] シンポジウム：B型肝炎診療「ウイルス増殖と免疫反応から」 HBV持続感染患者における免疫抑制のメカニズムとETV-IFN Sequential療法中における経時的免疫解析 (2012)
  • Author(s): 近藤泰輝
  • Organizer: 日本肝臓学会東部会
  • Place of Presentation: 東京
• [Presentation] IMMUNOLOGICAL AND VIROLOGICAL ANALYSIS OF HBV/HCV DUAL INFECTION AASLD (2011)
  • Author(s): Kondo Y, et al
  • Organizer: Annual Meeting
  • Place of Presentation: サンフランシスコ アメリカ
  • Year and Date: 2011-11-01
• [Presentation] HCV-CORE PROTEIN COULD INDUCE TH17 COMMITMENT BY ENHANCING THE STAT-3 SIGNALING AASLD (2011)
  • Author(s): Kondo Y, et al
  • Organizer: Annual Meeting
  • Place of Presentation: サンフランシスコアメリカ
  • Year and Date: 2011-11-01
• [Presentation] シンポジウム:消化器疾患と免疫慢性C型肝炎患者における自己免疫性疾患発生の新規メカニズム (2011)
  • Author(s): 近藤泰輝、上野義之、下瀬川徹
  • Organizer: JDDW
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] Vitamin DまたはDDFPP併用Peg-IFN/RBV治療は免疫細胞活性化を介して抗ウイルス効果を増強する (2011)
  • Author(s): 近藤泰輝, 他
  • Organizer: JDDW
  • Place of Presentation: 福岡
  • Year and Date: 2011-10-21
• [Presentation] C型肝炎治療におけるアフェレーシスの役割DFPP併用Peg-IFN/RBV治療は免疫細胞活性化を介して抗ウイルス効果を増強する (2011)
  • Author(s): 近藤泰輝, 他
  • Organizer: 日本アフェレーシス学会
  • Place of Presentation: 東京
  • Year and Date: 2011-09-30
• [Presentation] シンポジウム:免疫療法によるB型肝炎ウイルス制御のための病態解析 (2011)
  • Author(s): 近藤泰輝、上野義之、下瀬川徹
  • Organizer: 日本消化器免疫学会
  • Place of Presentation: 金沢
  • Year and Date: 2011-07-21
• [Presentation] HBV/HCV共感染患者における免疫病態解析 (2011)
  • Author(s): 近藤泰輝, 他
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] HBV複製肝癌細胞から産生されるケモカインの解析 (2011)
  • Author(s): 近藤泰輝, 他
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-06-02
• [Presentation] HBV/HCV共感染の免疫病態解析 (2011)
  • Author(s): 近藤泰輝, 他
  • Organizer: 日本内科学会総会
  • Place of Presentation: 東京
  • Year and Date: 2011-04-15
• [Presentation] B型C型肝炎ウイルス共感染症例における免疫学的検討 (2011)
  • Author(s): 近藤泰輝
  • Organizer: 日本内科学会総会
  • Place of Presentation: 東京
• [Presentation] 各種HBVジェノタイプ関連肝細胞癌から産生される液性因子の免疫病態に与える影響 (2011)
  • Author(s): 近藤泰輝
  • Organizer: 日本肝臓学会総会
  • Place of Presentation: 東京
• [Presentation] シンポジウム-消化器疾患の免疫療法：免疫療法によるB型肝炎ウイルス制御のための病態解析 (2011)
  • Author(s): 近藤泰輝
  • Organizer: 消化器免疫学会
  • Place of Presentation: 金沢
• [Presentation] ワークショップ-C型肝炎治療におけるアフェレシスの役割：DFPP併用Peg-IFN/RBV治療は免疫細胞活性化を介して抗ウイルス効果を増強する (2011)
  • Author(s): 近藤泰輝
  • Organizer: 日本アフェレーシス学会
  • Place of Presentation: 東京
• [Presentation] シンポジウム12 消化器疾患と免疫 慢性C型肝炎患者における自己免疫性疾患発生の新規メカニズム (2011)
  • Author(s): 近藤泰輝
  • Organizer: JDDW
  • Place of Presentation: 福岡
• [Presentation] Immunological and virological analysis of HBV/HCV dual infection (2011)
  • Author(s): Yasuteru Kondo
  • Organizer: AASLD
  • Place of Presentation: Sanfrancisco、アメリカ合衆国
• [Presentation] HCV-core protein could induce Th17 commitment by enhancing the STAT-3 signaling (2011)
  • Author(s): Yasuteru Kondo
  • Organizer: AASLD
  • Place of Presentation: Sanfrancisco、アメリカ合衆国
• [Book] C型肝炎のすべて2012 (2011)
  • Author(s): 近藤泰輝、上野義之、下瀬川徹
  • Total Pages: 6
  • Publisher: アークメディア
• [Remarks] ReaD & Researchmap
  • URL: http://researchmap.jp/read0139938/
• [Remarks]
  • URL: http://www.gastroente.med.tohoku.ac.jp/index.html