The multifactorial analysis and regulation of the immune evasion in viral-related hepatocellular carcinoma
| Project/Area Number |
23790761
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Gastroenterology
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
|---|
| Keywords | HBV / HCC / ケモカイン / NK Cell / T Cell / CX3CL1 / HCV / Tregs / NKG2D / NK cell / T cell |
|---|
| Research Abstract |
HBV-HCV viral interaction was occurred with immune cells. HCV-Core antigen could directly suppress the immune response. The expression patterns of chemokine were different among the various HBV genotypes. Among them, the expression level of CX3CL1 and the migration activity of NK cells were significantly different among HBV-genotypes. Moreover, the expression of NKG2D on the migrated NK cells was suppressed.
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Report
(3 results)
Research Products
(62 results)
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[Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants2012
Author(s)
Ninomiya M, Ueno Y, Funayama R, Kagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
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Journal Title
Journal of clinical microbiology
Volume: 50
Issue: 3
Pages: 857-866
DOI
Related Report
Peer Reviewed
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[Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2012
Author(s)
Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue Fukushima K, Sano K, Ueno Y, Shimosegawa T
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Journal Title
Virology
Volume: 20;422(2)
Pages: 377-85
Related Report
Peer Reviewed
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[Journal Article] TheNutritional Index 'CONUT' Is Useful for Predicting Long-Term Prognosis of Patients with End-Stage Liver Diseases
Author(s)
Fukushima K, Ueno Y, Kawagishi N, Kondo Y, Inoue J, Kakazu E, Ninomiya M, Wakui Y, Saito N, Satomi S, Shimosegawa T.
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Journal Title
Tohoku J Exp Med
Volume: 224(3)
Pages: 215-9
Related Report
Peer Reviewed
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