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The multifactorial analysis and regulation of the immune evasion in viral-related hepatocellular carcinoma

Research Project

Project/Area Number 23790761
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionTohoku University

Principal Investigator

KONDO Yasuteru  東北大学, 病院, 助教 (70455822)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
KeywordsHBV / HCC / ケモカイン / NK Cell / T Cell / CX3CL1 / HCV / Tregs / NKG2D / NK cell / T cell
Research Abstract

HBV-HCV viral interaction was occurred with immune cells. HCV-Core antigen could directly suppress the immune response. The expression patterns of chemokine were different among the various HBV genotypes. Among them, the expression level of CX3CL1 and the migration activity of NK cells were significantly different among HBV-genotypes. Moreover, the expression of NKG2D on the migrated NK cells was suppressed.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (62 results)

All 2013 2012 2011 Other

All Journal Article (24 results) (of which Peer Reviewed: 22 results) Presentation (35 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Eradication ofhepatitis C virus (HCV) could improve the immunological status and pyoderma gangrenosum-like lesion2013

    • Author(s)
      Kondo Y, Iwata T, Haga T, Kimura O, Ninomiya M, Kakazu E, Kogure T, Morosawa T, Aiba S, Shimosegawa T.
    • Journal Title

      Hepatology Research

      Volume: 44 Issue: 2 Pages: 4-4

    • DOI

      10.1111/hepr.12102

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PPARs and Liver Diseases2013

    • Author(s)
      Kondo Y, Uno K, Machida K and Terajima M
    • Journal Title

      PPAR Research

      Volume: 2013 Pages: 896412-896412

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hepatitis B surface antigen could contribute to the immunopathogenesis of hepatitis B virus infection.2013

    • Author(s)
      Yasuteru Kondo et al.
    • Journal Title

      ISRN Gastroenterol.

      Volume: 2013:935295 Pages: 935295-935295

    • DOI

      10.1155/2013/935295

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Murine models of non-alcoholic fatty liver disease and steatohepatitis2013

    • Author(s)
      Ninomiya M, Kondo Y, Shimosegawa T
    • Journal Title

      ISRN Hepatology Volume

    • URL

      http://dx.doi.org/10.1155/2013/237870

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] PPARs and liver disease2013

    • Author(s)
      Yasuteru Kondo et al.
    • Journal Title

      PPAR Res.

      Volume: 2013:896412 Pages: 1-2

    • DOI

      10.1155/2013/896412

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma.2012

    • Author(s)
      Osamu Kimura et al.
    • Journal Title

      PPAR Res.

      Volume: 2012(574180) Pages: 574180-574180

    • DOI

      10.1155/2012/574180

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between renal dysfunction and abnormalities of the immune system in patients with decompensated cirrhosis2012

    • Author(s)
      Kakazu E, Kondo Y, Shimosegawa T
    • Journal Title

      ISRN Gastroenterology

      Volume: 2012 Pages: 123826-123826

    • DOI

      10.5402/2012/123826

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Double filtration plasmapheresis could induce a favorable immune response for chronic hepatitis C therapy.2012

    • Author(s)
      Yasuteru Kondo et al.
    • Journal Title

      Ther Apher Dial.

      Volume: 16(5) Issue: 5 Pages: 478-479

    • DOI

      10.1111/j.1744-9987.2012.01113.x

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis.2012

    • Author(s)
      Jun Inoue et al.
    • Journal Title

      J Clin Virol.

      Volume: 55(2) Issue: 2 Pages: 147-152

    • DOI

      10.1016/j.jcv.2012.06.011

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] The influence of pioglitazone on the plasma amino acids profile in patients with Nonalcoholic Steatohepatitis (NASH)2012

    • Author(s)
      Kakazu E, Kondo Y, Ninomiya M, Kimura O, Nagasaki F, Ueno Y, Shimosegawa T.
    • Journal Title

      Hepatology International

      Volume: 2012 Issue: 2 Pages: 577-585

    • DOI

      10.1007/s12072-012-9395-y

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential Immunological Analysis of HBV/HCV Co-Infected Patients During2012

    • Author(s)
      Kondo Y, Ueno Y, Ninomiya M, Tamai K, Tanaka Y, Inoue J, Kakazu E, Kobayashi K, Shimosegawa T
    • Journal Title

      Peg-IFN/RBV therapy J Gastroenterol

      Volume: 47(12) Issue: 12 Pages: 1323-35

    • DOI

      10.1007/s00535-012-0596-x

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Biological Significance of HCV in various kinds of lymphoid cells2012

    • Author(s)
      Kondo Y, Ueno Y, Shimosegawa T.
    • Journal Title

      International Journal of Microbiology

      Volume: 2012 Pages: 1-7

    • DOI

      10.1155/2012/647581

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Use of illumina deep sequencing technology to differentiate hepatitis Cvirus variants2012

    • Author(s)
      Ninomiya M, Ueno Y, Funayama R, Kagashima T, Nishida Y, Kondo Y, Inoue J, Kakazu E, Kimura O, Nakayama K, Shimosegawa T
    • Journal Title

      Journal of clinical microbiology

      Volume: 50 Issue: 3 Pages: 857-866

    • DOI

      10.1128/jcm.05715-11

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway2012

    • Author(s)
      Tamai K, Shiina M, Tanaka N, Nakano T, Yamamoto A, Kondo Y, Kakazu E, Inoue Fukushima K, Sano K, Ueno Y, Shimosegawa T
    • Journal Title

      Virology

      Volume: 20;422(2) Pages: 377-85

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Sequential Immunological Analysis of HBV/HCV Co-Infected Patients During Peg-IFN/RBV therapy2012

    • Author(s)
      Yasuteru Kondo et al.
    • Journal Title

      Journal of Gastroenterology

      Volume: -

    • NAID

      10031145519

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Rapid Reduction of HCV-Core protein in the peripheral blood improve the immunological response in ChronicHepatitis2011

    • Author(s)
      Kondo Y, Ueno Y, Wakui Y, Ninomiya M, Kakazu E, Inoue J, Kobayashi K, Obara N, Shimosegawa T
    • Journal Title

      C patients Hepatol Res

      Volume: 41(12) Pages: 1153-68

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Toll Like Receptors (TLRs) Signaling Contribute to Immunopathogenesis of HBV Infection2011

    • Author(s)
      Kondo Y, Ueno Y, Shimosegawa T.
    • Journal Title

      Gastroenterol Res Pract

      Volume: 2011 Pages: 810939-810939

    • DOI

      10.1155/2011/810939

    • Related Report
      2012 Final Research Report 2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dysfunction of Immune Systems and HostGenetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT2011

    • Author(s)
      Kondo Y, Ueno Y, Shimosegawa T.
    • Journal Title

      Hepatitis Research and Treatment

      Volume: 2011 Pages: 1-7

    • DOI

      10.1155/2011/713216

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+circulating monocytes in patients with advanced cirrhosis2011

    • Author(s)
      E. Kakazu, Y. Ueno, Y. Kondo, J. Inoue, M. Ninomiya, O. Kimura, Y. Wakui, K. Fukushima, K. Tamai, T. Shimosegawa
    • Journal Title

      PLoS One

      Volume: 6 Issue: 8 Pages: 23402-23402

    • DOI

      10.1371/journal.pone.0023402

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enhanced Replication of Hepatitis B Virus with Frameshift in the Precore Region Found in Fulminant Hepatitis Patients2011

    • Author(s)
      Inoue J, Ueno Y, Wakui Y, Fukushima K, Kondo Y, Kakazu E, Ninomiya M, Niitsuma H,Shimosegawa T.
    • Journal Title

      J Infect Dis

      Volume: 1;204(7) Pages: 1017-25

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] B型肝炎ウイルス制御のための病態解析2011

    • Author(s)
      近藤泰輝、上野義之、下瀬川徹
    • Journal Title

      消化器と免疫(48)

      Pages: 62-65

    • Related Report
      2012 Final Research Report
  • [Journal Article] C型肝炎のすべて2012:症例に応じたDAA治療時期の選択2011

    • Author(s)
      近藤泰輝、上野義之、下瀬川徹
    • Journal Title

      肝胆膵

      Volume: 63(6) Pages: 1255-1260

    • Related Report
      2012 Final Research Report
  • [Journal Article] Rapid Reduction of HCV-Core protein in the peripheral blood improve the immunological response in Chronic Hepatitis C patients2011

    • Author(s)
      Yasuteru Kondo, Yoshiyuki Ueno, Yuta Wakui et al.
    • Journal Title

      Hepatology Research

      Volume: 41(12) Issue: 12 Pages: 1153-1168

    • DOI

      10.1111/j.1872-034x.2011.00878.x

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Journal Article] TheNutritional Index 'CONUT' Is Useful for Predicting Long-Term Prognosis of Patients with End-Stage Liver Diseases

    • Author(s)
      Fukushima K, Ueno Y, Kawagishi N, Kondo Y, Inoue J, Kakazu E, Ninomiya M, Wakui Y, Saito N, Satomi S, Shimosegawa T.
    • Journal Title

      Tohoku J Exp Med

      Volume: 224(3) Pages: 215-9

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Presentation] シンポジウムHBV持続感染患者における免疫抑制のメカニズムとETV-IFNSequential療法中における経時的免疫解析2012

    • Author(s)
      近藤泰輝, 他
    • Organizer
      日本肝臓学会東部会
    • Place of Presentation
      東京
    • Year and Date
      2012-12-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Vitamin D3 supplementation could improve the sensitivity of immune-response during2012

    • Author(s)
      Kondo Y et al
    • Organizer
      Peg-IFN/RBV therapy in chronic hepatitis C patients 10th STC-JSH 2012 Young Investigator Award
    • Place of Presentation
      東京
    • Year and Date
      2012-11-22
    • Related Report
      2012 Final Research Report
  • [Presentation] HBV-related hepatocellular carcinoma could express CX3CL1 and affect the migration of NKG2DlowCX3CR1+NK cells2012

    • Author(s)
      Kondo Y, et al
    • Organizer
      AASLD 2012 Annual Meeting
    • Place of Presentation
      ボストン、アメ リカ
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] Detection of a new genotype 1b lymphotropic HCV strain andanalysis of Th17 commitment2012

    • Author(s)
      Kondo Y, et al
    • Organizer
      AASLD 2012Annual Meeting
    • Place of Presentation
      ボストン、アメリカ
    • Year and Date
      2012-11-10
    • Related Report
      2012 Final Research Report
  • [Presentation] パネルディスカッションTh17分化誘導によるHCV関連自己免疫疾患発症の可能性2012

    • Author(s)
      近藤泰輝, 他
    • Organizer
      日本肝臓学会大会JDDW
    • Place of Presentation
      神戸
    • Year and Date
      2012-10-11
    • Related Report
      2012 Final Research Report
  • [Presentation] IL28B,ITPA polymorphismとVitamin D濃度からみた肝移植後C型肝炎治療今後の可能性2012

    • Author(s)
      近藤泰輝, 他
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] HBV関連肝細胞癌より放出される液性因子は免疫細胞浸潤能、活性化に影響を与えるワークショップ2012

    • Author(s)
      近藤泰輝, 他
    • Organizer
      第48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Vitamin D3製剤併用Peg-IFN/RBV治療の成績(多施設共同研究)オープンワークショップ2012

    • Author(s)
      近藤泰輝, 他
    • Organizer
      48回日本肝臓学会総会
    • Place of Presentation
      金沢
    • Year and Date
      2012-06-07
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapid Reduction of HCV-core Protein in the peripheral Blood induces Favorable Effect in Treatment ofChronic Hepatitis C Patients2012

    • Author(s)
      Kondo Y, et al
    • Organizer
      IF-Best Poster Award Presentation in the 3rd International Forum JSGE
    • Place of Presentation
      東京
    • Year and Date
      2012-04-20
    • Related Report
      2012 Final Research Report
  • [Presentation] The CX3CL1 produced fromHBV-replicated human hepatoma cells could affect the migration activity of lymphoid cells2012

    • Author(s)
      Kondo Y, et al
    • Organizer
      APASL 2012 Annual Meeting
    • Place of Presentation
      台北台湾
    • Year and Date
      2012-02-17
    • Related Report
      2012 Final Research Report
  • [Presentation] Rapid Reduction of HCV-Core protein in the peripheral blood induces favorable effect in treatment of Chronic Hepatitis C patients2012

    • Author(s)
      Yasuteru Kondo
    • Organizer
      日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] ワークショップ 肝細胞癌に対する免疫の基礎と治療への展開 HBV関連肝細胞癌より放出される液性因子は免疫細胞浸潤能、活性化に影響を与える2012

    • Author(s)
      近藤泰輝
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] Vitamin D3製剤併用Peg-IFN/RBV治療の成績(多施設共同研究)2012

    • Author(s)
      近藤泰輝
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] IL28B, ITPA polymorphismとVitamin D濃度からみた肝移植後C型肝炎治療今後の可能性2012

    • Author(s)
      近藤泰輝
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      金沢
    • Related Report
      2012 Annual Research Report
  • [Presentation] パネルディスカッション:ウイルス性肝炎と肝外病変 Th17分化誘導によるHCV関連自己免疫疾患発症の可能性2012

    • Author(s)
      近藤泰輝
    • Organizer
      JDDW
    • Place of Presentation
      神戸
    • Related Report
      2012 Annual Research Report
  • [Presentation] Detection of a new genotype 1b lymphotropic HCV strain and the analysis of Th17 commitment.2012

    • Author(s)
      Yasuteru Kondo
    • Organizer
      AASLD Annual Meeting
    • Place of Presentation
      ボストン、アメリカ
    • Related Report
      2012 Annual Research Report
  • [Presentation] HBV-related hepatocellular carcinoma could express CX3CL1 and affect the migration of NKG2DlowCX3CR1+NK cells2012

    • Author(s)
      Yasuteru Kondo
    • Organizer
      AASLD Annual Meeting
    • Place of Presentation
      ボストン、アメリカ
    • Related Report
      2012 Annual Research Report
  • [Presentation] Distinguished Presentation: Vitamin D3 supplementation could improve the sensitivity of immune-response during Peg-IFN/RBV therapy in chronic hepatitis C patients2012

    • Author(s)
      Yasuteru Kondo
    • Organizer
      The 10th JSH Single Topic Conference “Hepatitis C: Best Practice Based on Science”
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] シンポジウム:B型肝炎診療「ウイルス増殖と免疫反応から」 HBV持続感染患者における免疫抑制のメカニズムとETV-IFN Sequential療法中における経時的免疫解析2012

    • Author(s)
      近藤泰輝
    • Organizer
      日本肝臓学会東部会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] IMMUNOLOGICAL AND VIROLOGICAL ANALYSIS OF HBV/HCV DUAL INFECTION AASLD2011

    • Author(s)
      Kondo Y, et al
    • Organizer
      Annual Meeting
    • Place of Presentation
      サンフランシスコ アメリカ
    • Year and Date
      2011-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] HCV-CORE PROTEIN COULD INDUCE TH17 COMMITMENT BY ENHANCING THE STAT-3 SIGNALING AASLD2011

    • Author(s)
      Kondo Y, et al
    • Organizer
      Annual Meeting
    • Place of Presentation
      サンフランシスコアメリカ
    • Year and Date
      2011-11-01
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム:消化器疾患と免疫慢性C型肝炎患者における自己免疫性疾患発生の新規メカニズム2011

    • Author(s)
      近藤泰輝、上野義之、下瀬川徹
    • Organizer
      JDDW
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Vitamin DまたはDDFPP併用Peg-IFN/RBV治療は免疫細胞活性化を介して抗ウイルス効果を増強する2011

    • Author(s)
      近藤泰輝, 他
    • Organizer
      JDDW
    • Place of Presentation
      福岡
    • Year and Date
      2011-10-21
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] C型肝炎治療におけるアフェレーシスの役割DFPP併用Peg-IFN/RBV治療は免疫細胞活性化を介して抗ウイルス効果を増強する2011

    • Author(s)
      近藤泰輝, 他
    • Organizer
      日本アフェレーシス学会
    • Place of Presentation
      東京
    • Year and Date
      2011-09-30
    • Related Report
      2012 Final Research Report
  • [Presentation] シンポジウム:免疫療法によるB型肝炎ウイルス制御のための病態解析2011

    • Author(s)
      近藤泰輝、上野義之、下瀬川徹
    • Organizer
      日本消化器免疫学会
    • Place of Presentation
      金沢
    • Year and Date
      2011-07-21
    • Related Report
      2012 Final Research Report
  • [Presentation] HBV/HCV共感染患者における免疫病態解析2011

    • Author(s)
      近藤泰輝, 他
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report 2011 Research-status Report
  • [Presentation] HBV複製肝癌細胞から産生されるケモカインの解析2011

    • Author(s)
      近藤泰輝, 他
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-06-02
    • Related Report
      2012 Final Research Report
  • [Presentation] HBV/HCV共感染の免疫病態解析2011

    • Author(s)
      近藤泰輝, 他
    • Organizer
      日本内科学会総会
    • Place of Presentation
      東京
    • Year and Date
      2011-04-15
    • Related Report
      2012 Final Research Report
  • [Presentation] B型C型肝炎ウイルス共感染症例における免疫学的検討2011

    • Author(s)
      近藤泰輝
    • Organizer
      日本内科学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 各種HBVジェノタイプ関連肝細胞癌から産生される液性因子の免疫病態に与える影響2011

    • Author(s)
      近藤泰輝
    • Organizer
      日本肝臓学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] シンポジウム-消化器疾患の免疫療法:免疫療法によるB型肝炎ウイルス制御のための病態解析2011

    • Author(s)
      近藤泰輝
    • Organizer
      消化器免疫学会
    • Place of Presentation
      金沢
    • Related Report
      2011 Research-status Report
  • [Presentation] ワークショップ-C型肝炎治療におけるアフェレシスの役割:DFPP併用Peg-IFN/RBV治療は免疫細胞活性化を介して抗ウイルス効果を増強する2011

    • Author(s)
      近藤泰輝
    • Organizer
      日本アフェレーシス学会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] シンポジウム12 消化器疾患と免疫 慢性C型肝炎患者における自己免疫性疾患発生の新規メカニズム2011

    • Author(s)
      近藤泰輝
    • Organizer
      JDDW
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] Immunological and virological analysis of HBV/HCV dual infection2011

    • Author(s)
      Yasuteru Kondo
    • Organizer
      AASLD
    • Place of Presentation
      Sanfrancisco、アメリカ合衆国
    • Related Report
      2011 Research-status Report
  • [Presentation] HCV-core protein could induce Th17 commitment by enhancing the STAT-3 signaling2011

    • Author(s)
      Yasuteru Kondo
    • Organizer
      AASLD
    • Place of Presentation
      Sanfrancisco、アメリカ合衆国
    • Related Report
      2011 Research-status Report
  • [Book] C型肝炎のすべて20122011

    • Author(s)
      近藤泰輝、上野義之、下瀬川徹
    • Total Pages
      6
    • Publisher
      アークメディア
    • Related Report
      2011 Research-status Report
  • [Remarks] ReaD & Researchmap

    • URL

      http://researchmap.jp/read0139938/

    • Related Report
      2012 Final Research Report
  • [Remarks]

    • URL

      http://www.gastroente.med.tohoku.ac.jp/index.html

    • Related Report
      2012 Final Research Report

URL: 

Published: 2011-08-05   Modified: 2019-07-29  

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