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Analysis of maintenance and repair mechanism of the intestinal mucosa by the Notch ligand-receptor system

Research Project

Project/Area Number 23790776
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Gastroenterology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

MORIO Junko (AKIYAMA Junko)  東京医科歯科大学, 医学部, 非常勤講師 (70581297)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords炎症性腸疾患 / Notchシグナル / 腸管上皮 / 分化制御 / 杯細胞 / 大腸炎 / Notchリガンド
Research Abstract

Analysis of normal and inflamed intestinal mucosa of mice revealed that mRNA of Notch ligands, DLL1, DLL4 and JAG1, is expressed within those tissues. Further analysis by immunohistochemistry showed that DLL1 and DLL4 are surely expressed in intestinal epithelial cells. Targeted disruption of DLL1 and DLL4 in intestinal stem cells clearly shifted the differentiation of intestinal epithelial cells towards secretory lineage cells, which clearly demonstrated that DLL1 and DLL4 surely has an indispensable functional role within the intestinal epithelium.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (17 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (14 results)

  • [Journal Article] Chronic Inflammatory Demyelinating Polyradiculoneuropathy in a Patient with Crohn's Disease2013

    • Author(s)
      Ohyagi , Akiyama J, Watanabe M et al
    • Journal Title

      Internal Medicine

      Volume: 52 Issue: 1 Pages: 125-128

    • DOI

      10.2169/internalmedicine.52.8452

    • NAID

      130003365560

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoscopic ultrasound with double-balloon endoscopy for the diagnosis of inverted Meckel'sdiverticulum: a case report2012

    • Author(s)
      Araki A, Tsuchiya K, Oshima S, Okada E,Suzuki S, Akiyama JM, Fujii T, OkamotoR, Watanabe M
    • Journal Title

      J Med Case Rep

      Volume: 6(1) Issue: 1 Pages: 328-328

    • DOI

      10.1186/1752-1947-6-328

    • Related Report
      2012 Annual Research Report 2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Histological Diagnosis ofFollicular Lymphoma by Biopsy of SmallIntestinal Normal Mucosa2012

    • Author(s)
      Okada E, Araki A, Suzuki S, Watanabe H, Ikeda T, Watanabe T, Kurata M, EishiY, Watanabe M
    • Journal Title

      Dig Endosc

      Volume: in press Issue: 5 Pages: 22-22

    • DOI

      10.1111/j.1443-1661.2012.01386.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Complete conversion of crypt progenitor cells into Atoh1-positive cells by targeted deletion of Dll1 and Dll4 in LGR5-positive intestinal stem cells.2013

    • Author(s)
      Shimizu H, Morio-Akiyama J, Watanabe M et al
    • Organizer
      DDW 2013
    • Place of Presentation
      オーランド
    • Related Report
      2012 Annual Research Report
  • [Presentation] Identification of Notch ligand expressing cells in normal and inflamed intestinal mucosa2012

    • Author(s)
      Shimizu H, Ryuichi Okamoto, Tatsuro Murano, Go Ito, Satoru Fujii, Morio-Akiyama Junko, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
    • Organizer
      Asian IBD Symposium Seoul 2012.
    • Place of Presentation
      Seoul
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] Notch pathway and TNF-a synergistically up-regulates OLFM4 expression in the inflamed mucosa of the human intestine2012

    • Author(s)
      Ryuichi Okamoto, Morio-Akiyama Junko, Hiromichi Shimizu, Tatsuro Murano, Go Ito, Satoru Fujii, Kiichiro Tsuchiya, Tetsuya Nakamura, Mamoru Watanabe
    • Organizer
      Asian IBD Symposium Seoul 2012.
    • Place of Presentation
      Seoul
    • Year and Date
      2012-11-03
    • Related Report
      2012 Final Research Report
  • [Presentation] 非典型的な画像所見を呈し診断に難渋した転移性肝血管肉腫の一例2012

    • Author(s)
      武井ゆりあ、吉野耕平、東正新、藤木純子、藤井俊光、森尾純子、齊藤詠子、櫻井幸、中川美奈、大岡真也、長堀正和、土屋輝一郎、渡辺守、裴有安、小林大輔
    • Organizer
      第319回日本消化器病学会関東支部例会
    • Place of Presentation
      東京
    • Year and Date
      2012-05-26
    • Related Report
      2012 Final Research Report
  • [Presentation] 炎症性腸疾患患者における抗TNFα受容体拮抗薬の選択に関する研究2012

    • Author(s)
      長堀正和、藤井俊光、齊藤詠子、森尾純子、長沼誠、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] 難治性潰瘍性大腸炎に対するTacrolimus静注療法の有用性と安全性の検討2012

    • Author(s)
      藤井俊光、齊藤詠子、森尾純子、長堀正和、長沼誠、渡辺守
    • Organizer
      第98回日本消化器病学会総会
    • Place of Presentation
      東京
    • Year and Date
      2012-04-21
    • Related Report
      2012 Final Research Report
  • [Presentation] Identification of Notch ligand expressing cells in normal and inflamed intestinal mucosa2012

    • Author(s)
      Shimizu H, Morio-Akiyama J, Watanabe M et al
    • Organizer
      Asian IBD Symposium Seoul 2012
    • Place of Presentation
      ソウル
    • Related Report
      2012 Annual Research Report
  • [Presentation] Serological test and vaccinations for Measles, Mumps, Rubella, and Varicella Zoster deserve considerations as early as possible after diagnosis of Inflammatory Bowel Disease.2011

    • Author(s)
      Naganuma M, Nagahori M, Fujii T, Akiyama J, Saito E, Watanabe M
    • Organizer
      UEGW2011
    • Place of Presentation
      Stockholm
    • Related Report
      2011 Research-status Report
  • [Presentation] IBD患者における風疹・麻疹・水痘・ムンプスに対する抗体価測定の意義2011

    • Author(s)
      長沼 誠、長堀正和、藤井俊光、秋山純子、齋藤詠子、渡辺 守
    • Organizer
      第15回日本消化器病学会総会
    • Place of Presentation
      福岡
    • Related Report
      2011 Research-status Report
  • [Presentation] 術後に判明した空腸異所性膵炎の一例2011

    • Author(s)
      鈴木康平、秋山純子、藤井俊光、櫻井 幸、福田将義、吉野耕平、竹中健人、東 正新、鈴木伸治、長堀正和、長沼 誠、坂本直哉、渡辺 守、小林宏寿、杉原健一、伊藤栄作、三浦圭子
    • Organizer
      第16回お茶の水消化器セミナー
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] チオプリン、タクロリムス不応例潰瘍性大腸炎に対するインフリキシマブ(IFX)の検討2011

    • Author(s)
      秋山純子、長沼 誠、藤井俊光、玄 世鋒、長堀正和、渡辺 守
    • Organizer
      第97回日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2011 Research-status Report
  • [Presentation] 非典型的な画像所見を呈し診断に難渋した転移性肝血管肉腫の一例

    • Author(s)
      武井ゆりあ、森尾純子、渡辺 守 他
    • Organizer
      第319回 日本消化器病学会関東支部例会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 炎症性腸疾患患者における抗TNFα受容体拮抗薬の選択に関する研究

    • Author(s)
      長堀正和、藤井俊光、齊藤詠子、森尾純子、長沼 誠、渡辺 守
    • Organizer
      第98回 日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 難治性潰瘍性大腸炎に対するTacrolimus静注療法の有用性と安全性の検討

    • Author(s)
      藤井俊光、齊藤詠子、森尾純子、長堀正和、長沼 誠、渡辺 守
    • Organizer
      第98回 日本消化器病学会総会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report

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Published: 2011-08-05   Modified: 2019-07-29  

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