Development of secondary prevention for hepatocellular carcinoma by enhancement of anti-tumor immunity stimulated by chemokine agents.

• Project/Area Number: 23790781
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Gastroenterology
• Research Institution: Kanazawa University
• Principal Investigator: ARAI Kuniaki 金沢大学, 大学病院, 助教 (50436838)
• Project Period (FY): 2011 – 2013
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 抗腫瘍免疫 / 肝細胞癌 / 免疫療法 / 樹状細胞 / ラジオ波焼灼療法

Research Abstract

The aim of this study is development of secondary prevention for hepatocellular carcinoma (HCC) by enhancement of anti-tumor immunity stimulated by chemokine agents in radiofrequency ablation (RFA) therapy with dendritic cell (DC) injection into HCC. We analyzed cellular immune response of DC and various method of introduction of DC. We revealed that stimulation of OK-432 enhances antigen presentation activity and immunopotentiative action. We started clinical trial of OK-432 stimulated DC injection into HCC after RFA therapy. Progression free survival in the group treated with RFA + OK432 stimulated DC transfer was much better.

Research Products

• [Journal Article] Liver cancer : progress in diagnosis and treatments. Topics : IV. Progress in guideline on liver cancer; 3 (2014)
  • Author(s): Arai K, Yamashita T, Kaneko S
  • Journal Title: Guideline of surveillance]. Nihon Naika Gakkai Zasshi Volume: 103(1) Pages: 37-43
• [Journal Article] Liver cancer : progress in diagnosis and treatments. Topics : VI. Progress in treatments of liver cancer; 5 (2014)
  • Author(s): Yamashita T, Arai K, Kaneko S
  • Journal Title: Chemotherapy. Nihon Naika Gakkai Zasshi Volume: 103(1) Pages: 102-9
• [Journal Article] Feasibility and efficacy of hepatic arterial infusion chemotherapy for advanced hepatocellular carcinoma after sorafenib. (2013)
  • Author(s): Terashima T, Yamashita T, Arai K, Sunagozaka H, Kitahara M, Nakagawa H, Kagaya T, Mizukoshi E, Honda M, Kaneko S.
  • Journal Title: Hepatol Res. Volume: Oct 31 Issue: 12 Pages: 1-7
  • DOI: 10.1111/hepr.12266
  • NAID: 120005537892
  • Peer Reviewed / Open Access
• [Journal Article] Evaluation of eligibility criteria in living donor liver transplantation for hepatocellular carcinoma byα-SMA -positive cancer-associated fibroblasts (2013)
  • Author(s): Takamura H, Arai K, 他27名
  • Journal Title: Oncol Rep Volume: 30(4) Issue: 4 Pages: 1561-74
  • DOI: 10.3892/or.2013.2616
  • Peer Reviewed
• [Journal Article] 進行肝癌治療Q69.わが国のソラフェニブ治療の実態と治療成績はどのくらいですか? (2013)
  • Author(s): 山下竜也,荒井邦明,金子周一
  • Journal Title: 肝癌診療Q&A Pages: 277-280
• [Journal Article] Increase in CD14+HLA-DR -/low myeloid-derived suppressor cells in hepatocellular carcinoma patients and its impact on prognosis. (2013)
  • Author(s): Arihara F, Mizukoshi E, Kitahara M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S
  • Journal Title: Cancer Immunol Immunother. Volume: 62(8) Issue: 8 Pages: 1421-1430
  • DOI: 10.1007/s00262-013-1447-1
  • Peer Reviewed
• [Journal Article] Peretinoin, an acyclic retinoid, improves the hepatic gene signature of chronic hepatitis C following curative therapy of hepatocellular carcinoma. (2013)
  • Author(s): Honda M, Yamashita T, Yamashita T, Arai K, Sakai Y, Sakai A, Nakamura M, Mizukoshi E, Kaneko S.
  • Journal Title: BMC Cancer. Volume: 15 Issue: 1 Pages: 191-191
  • DOI: 10.1186/1471-2407-13-191
  • Peer Reviewed
• [Journal Article] Association of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C. (2013)
  • Author(s): Hodo Y, Honda M, Tanaka A, Nomura Y, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Sakai A, Sasaki M, Nakanuma Y, Moriyama M, Kaneko S.
  • Journal Title: Clin Cancer Res. Volume: 19 Issue: 7 Pages: 1827-37
  • DOI: 10.1158/1078-0432.ccr-12-1641
  • Peer Reviewed
• [Journal Article] Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma (2013)
  • Author(s): 水腰英四郎, 山下竜也
  • Journal Title: Hepatology Volume: 57 Issue: 4 Pages: 1448-1457
  • DOI: 10.1002/hep.26153
  • NAID: 120005254062
  • Peer Reviewed
• [Journal Article] 【肝細胞癌のすべて2012】肝がんの治療アルゴリズム海外(APASL, EASL/EORTC, AASLD)の診療ガイドライン (2012)
  • Author(s): 荒井邦明,山下竜也,金子周一
  • Journal Title: 肝・胆・膵 Volume: 65巻6号 Pages: 1199-1204
• [Journal Article] 【肝細胞癌のすべて2012】治療方別の治療効果判定の実際肝動注化学療法 (2012)
  • Author(s): 山下竜也,荒井邦明,金子周一
  • Journal Title: 肝・胆・膵 Volume: 65巻6号 Pages: 1364-1369
• [Journal Article] Expression of Chondroitin-glucuronate C5-epimerase and Cellular Immune Responses in Patients with Hepatocellular Carcinoma (2012)
  • Author(s): 水腰英四郎, 伏見一美
  • Journal Title: Liver International Volume: 32 Issue: 10 Pages: 1516-1526
  • DOI: 10.1111/j.1478-3231.2012.02853.x
  • NAID: 120004997021
  • Peer Reviewed
• [Journal Article] 【肝・胆・膵腫瘍の薬物療法-最近の進歩】肝がんソラフェニブの新たな展開(適応承認後明らかになってきた治療成績、課題、新たな臨床試験など) (2012)
  • Author(s): 山下竜也,荒井邦明,金子周一
  • Journal Title: 腫瘍内科 Volume: 9巻6号 Pages: 641-650
• [Journal Article] 【肝胆膵悪性腫瘍に対する分子標的療法の近未来的展望】肝細胞癌Sorafenib (2012)
  • Author(s): 山下竜也,荒井邦明,金子周一
  • Journal Title: 肝・胆・膵 Volume: 64巻5号 Pages: 645-655
• [Journal Article] Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population. (2012)
  • Author(s): Nakamura M
  • Journal Title: Am J Hum Genet. Volume: 91 Issue: 4 Pages: 721-728
  • DOI: 10.1016/j.ajhg.2012.08.010
  • Peer Reviewed
• [Journal Article] Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression. (2012)
  • Author(s): Takeshita Y, Takamura T, Inoue O, Okumura M, Kato K, Sunagozaka H, Arai K, Misu H, Nakamura M, Nakanuma Y, Kaneko S.
  • Journal Title: Intern Med. Volume: 51 Pages: 79-82
  • NAID: 130002062431
  • Peer Reviewed
• [Journal Article] 【肝細胞癌のすべて2012】 肝がんの治療アルゴリズム 海外（APASL, EASL/EORTC, AASLD）の診療ガイドライン (2012)
  • Author(s): 荒井 邦明, 山下 竜也, 金子 周一
  • Journal Title: 肝・胆・膵 Volume: 65 Pages: 1199-1204
• [Journal Article] 【肝細胞癌のすべて2012】 治療方別の治療効果判定の実際 肝動注化学療法 (2012)
  • Author(s): 山下 竜也, 荒井 邦明, 金子 周一
  • Journal Title: 肝・胆・膵 Volume: 65 Pages: 1364-1369
• [Journal Article] 肝細胞癌に対するソラフェニブ治療の効果判定基準の比較 (2012)
  • Author(s): 荒井 邦明, 山下 竜也, 寺島 健志，北原 征明，砂子阪 肇，金子 周一
  • Journal Title: The Liver Cancer Journal Volume: 4 Pages: 314-315
• [Journal Article] 進行肝細胞癌に対してS-1単剤投与が奏効した1例 (2012)
  • Author(s): 山下 竜也, 荒井 邦明, 寺島 健志, 砂子阪 肇, 島上 哲朗, 山下 太郎, 水腰 英四郎, 酒井 明人, 本多 政夫, 金子 周一
  • Journal Title: 癌と化学療法 Volume: 39 Pages: 1435-1437
• [Journal Article] 【いわゆる良性腫瘍のマリグナントプログレッション】 肝細胞性腫瘍:異型結節(デスプラジア結節)/早期肝細胞癌と高分化型細胞癌(古典的) 早期診断、癌化診断 最近のモダリティを用いて (2012)
  • Author(s): 北尾 梓，米田 憲秀, 小坂 一斗, 新村 理絵子, 南 哲弥, 龍 泰治, 香田 渉, 眞田 順一郎, 小林 聡, 蒲田 敏文, 荒井 邦明, 山下 太郎, 山下 竜也, 金子 周一, 中沼 安二, 松井 修
  • Journal Title: 肝・胆・膵 Volume: 65 Pages: 439-448
• [Journal Article] 【肝・胆・膵腫瘍の薬物療法-最近の進歩】 肝がん ソラフェニブの新たな展開(適応承認後明らかになってきた治療成績、課題、新たな臨床試験など) (2012)
  • Author(s): 山下 竜也, 荒井 邦明, 金子 周一
  • Journal Title: 腫瘍内科 Volume: 9 Pages: 641-650
• [Journal Article] 【肝胆膵悪性腫瘍に対する分子標的療法の近未来的展望】 肝細胞癌 Sorafenib (2012)
  • Author(s): 山下 竜也, 荒井 邦明, 金子 周一
  • Journal Title: 肝・胆・膵 Volume: 64 Pages: 645-655
• [Journal Article] 当科における80歳以上の高齢者肝細胞癌患者に対するラジオ波焼灼療法の現状 (2012)
  • Author(s): 砂子阪 肇， 山下 竜也, 北原 征明, 荒井 邦明, 金子 周一
  • Journal Title: 医学と薬学 Volume: 67 Pages: 66-68
• [Journal Article] Randomized, phase II study comparing interferon combined with hepatic arterial infusion of fluorouracil plus cisplatin and fluorouracil alone in patients with advanced hepatocellularcar cinoma (2011)
  • Author(s): Honda M, (他10名, 10番目)
  • Journal Title: Oncology Volume: 81(5-6) Issue: 5-6 Pages: 281-90
  • DOI: 10.1159/000334439
  • NAID: 120003674297
  • Peer Reviewed
• [Journal Article] Identification of a secretory protein c19orf10 activated in hepatocellular carcinoma (2011)
  • Author(s): Sunagozaka H, Honda M, 他7名
  • Journal Title: Int J Cancer Volume: 129(7) Issue: 7 Pages: 1576-85
  • DOI: 10.1002/ijc.25830
  • NAID: 120003339367
  • Peer Reviewed
• [Journal Article] 【肝細胞癌の化学療法-分子標的治療の進歩と効果判定】各論肝細胞癌の化学療法の進歩肝細胞癌の動注化学療法の進歩と治療成績 (2011)
  • Author(s): 山下竜也,荒井邦明,金子周一
  • Journal Title: 肝胆膵画像(1882-5087) Volume: 13巻6号 Pages: 602-607
• [Journal Article] Frequency of CD45RO+ subset in CD4+CD25(high) regulatory T cells associated with progression of hepatocellular carcinoma (2011)
  • Author(s): Takata Y, Nakamoto Y, Nakada A, Terashima T, Arihara F, Kitahara M, Kakinoki K, Arai K, Yamashita T, Sakai Y, Yamashita T, Mizukoshi E, Kaneko S
  • Journal Title: Cancer Lett Volume: 307 Issue: 2 Pages: 165-173
  • DOI: 10.1016/j.canlet.2011.03.029
  • NAID: 120003141809
  • Peer Reviewed
• [Journal Article] 【肝細胞がん診療の進歩 : Up-To-Date】治療肝細胞がんに対する肝動注化学療法の位置づけ (2011)
  • Author(s): 山下竜也,荒井邦明,金子周一
  • Journal Title: 最新医学(0370-8241) Volume: 66巻8号 Pages: 1804-1810
• [Journal Article] Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma (2011)
  • Author(s): Honda M, (他9名, 9番目)
  • Journal Title: Hepatology Volume: 53(4) Issue: 4 Pages: 206-16
  • DOI: 10.1002/hep.24149
  • Peer Reviewed
• [Journal Article] 当科における肝癌局所療法後の再発とその対策 (2011)
  • Author(s): 北原征明, 山下竜也, 砂子阪肇, 荒井邦明, 金子周一
  • Journal Title: 医学と薬学 Volume: 66 Pages: 208-211
• [Journal Article] 【肝細胞癌の化学療法-分子標的治療の進歩と効果判定】 各論 肝細胞癌の化学療法の進歩 肝細胞癌の動注化学療法の進歩と治療成績 (2011)
  • Author(s): 山下竜也, 荒井邦明, 金子周一
  • Journal Title: 肝胆膵画像 Volume: 13 Pages: 1804-1810
• [Journal Article] 【消化器癌の予防とサーベイランス】 肝臓癌の予防とサーベイランス (2011)
  • Author(s): 酒井明人, 荒井邦明, 金子周一
  • Journal Title: G.I.Research Volume: 19 Pages: 334-341
• [Presentation] The impact of post-progression survival on overall survival of patients with advanced hepatocellular carcinoma treated by sorafenib therapy (2013)
  • Author(s): T Terashima, T Yamashita, N Takata, H Nakagawa, K Arai, T Kagaya, E Mizukoshi, M Hondo, S Kaneko
  • Organizer: AASLD2013 2094
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2013-11-05
• [Presentation] Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma with stem cell features (2013)
  • Author(s): H Sunagozaka, T Yamashita, N Oishi, T Hayashi, H Takatori, T Shimakami, K Kitamura, K Arai, T Kagaya, Y Sakai, T Yamashita, E Mizukoshi, M Hondo, S Kaneko
  • Organizer: AASLD2013 1792
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2013-11-05
• [Presentation] Phase I Trial of Alpha-Fetoprotein-Derived Peptides in the Treatment of Hepatocellular Carcinoma (2013)
  • Author(s): E Mizukoshi, T Yamashita, K Arai, H Sunagozaka, K Fushimi, H Nakagawa, K Yamada, K Kaji, M Kitahara, S Kaneko
  • Organizer: AASLD2013 251
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2013-11-05
• [Presentation] Therapeutic Efficacy and Safety of OK432-Stimulated Monocyte-Derived Dendritic Cell Injection into Hepotocellular Carcinoma after Radiofrequency Ablation (2013)
  • Author(s): M Kitahara, E Mizukoshi, K Kaji, K Yamada, H Nakagawa, H Sunagozaka, K Arai, T Yamashita, S Kaneko
  • Organizer: AASLD2013 1265
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2013-11-04
• [Presentation] Cellular immune responses for human homologue of Prp24p-derived peptides in patients with Hepatocellular Carcinoma (2013)
  • Author(s): K Kaji, E Mizukoshi, T Yamashita, K Arai, H Sunagozaka, K Fushimi, H Nakagawa, K Yamada, M Kitahara, S Kaneko
  • Organizer: AASLD2013 1262
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2013-11-04
• [Presentation] Assessment of the therapeutic response of hepatocellular carcinoma treated with radiofrequency ablation : comparison of contrast-enhanced ultrasonography and computed tomography (2013)
  • Author(s): K Arai, T Yamashita, E Mizukoshi, S Kaneko
  • Organizer: WFUMB 2013 PA03-004
  • Place of Presentation: Sao Paulo, Brazil
• [Presentation] Contrast-enhanced ultra -sonography for evaluating treatment of sorafenib in hepatocellular carcinoma (2013)
  • Author(s): K Arai, T Yamashita, E Mizukoshi, S Kaneko
  • Organizer: WFUMB 2013 PA03-003
  • Place of Presentation: Sao Paulo, Brazil
• [Presentation] Assessment of the therapeutic response of hepatocellular carcinoma treated with radiofrequency ablation : comparison of contrast-enhanced ultrasonography and computed tomography. (2013)
  • Author(s): Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
  • Organizer: WFUMB 2013
  • Place of Presentation: SAO PAULO, Brazil
• [Presentation] Contrast -enhanced ultrasonography for evaluating treatment of sorafenib in hepatocellular carcinoma. (2013)
  • Author(s): Kuniaki Arai, Tatsuya Yamashita, Eishiro Mizukoshi, Shuichi Kaneko
  • Organizer: WFUMB 2013
  • Place of Presentation: SAO PAULO, Brazil
• [Presentation] Phase I Trial of Alpha-Fetoprotein-Derived Peptides in the Treatment of Hepatocellular Carcinoma. (2013)
  • Author(s): Eishiro Mizukoshi, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Hidetoshi Nakagawa, Kazutoshi Yamada, Kiichiro Kaji, Masaaki Kitahara, Shuichi Kaneko
  • Organizer: AASLD2013
  • Place of Presentation: Washington DC, USA
• [Presentation] Cellular immune responses for human homologue of Prp24p-derived peptides in patients with Hepatocellular Carcinoma. (2013)
  • Author(s): Kiichiro Kaji, Eishiro Mizukoshi, Tatsuya Yamashita, Kuniaki Arai, Hajime Sunagozaka, Kazumi Fushimi, Hidetoshi Nakagawa, Kazutoshi Yamada, Masaaki Kitahara, Shuichi Kaneko
  • Organizer: AASLD2013
  • Place of Presentation: Washington DC, USA
• [Presentation] Therapeutic Efficacy and Safety of OK432-Stimulated Monocyte-Derived Dendritic Cell Injection into Hepotocellular Carcinoma after Radiofrequency Ablation. (2013)
  • Author(s): Masaaki Kitahara, Eishiro Mizukoshi, Kiichiro Kaji, Kazutoshi Yamada, Hidetoshi Nakagawa, Hajime Sunagozaka, Kuniaki Arai, Tatsuya Yamashita, Shuichi Kaneko
  • Organizer: AASLD2013
  • Place of Presentation: Washington DC, USA
• [Presentation] Serum Dickkopf-1 as a biomarker for the diagnosis of hepatocellular carcinoma with stem cell features. (2013)
  • Author(s): Hajime Sunagozaka, Toro Yamashita, Naoki Oishi, Takehiro Hayashi, Hajime Takatori, Tetsuro Shimakami, Kazuya Kitamura, Kuniaki Arai, Takashi Kagaya, Yoshio Sakai, Tatsuya Yamashita, Eishiro Mizukoshi, Masao Hondo, Shuichi Kaneko
  • Organizer: AASLD2013
  • Place of Presentation: Washington DC, USA
• [Presentation] The impact of post-progression survival on overall survival of patients with advanced hepatocellular carcinoma treated by sorafenib therapy. (2013)
  • Author(s): Takeshi Terashima, tatsuya Yamashita, Noboru Takata, Hidetoshi Nakagawa, Kuniaki Arai, Takashi Kagaya, Eishiro Mizukoshi, Masao Hondo, Shuichi Kaneko
  • Organizer: AASLD2013
  • Place of Presentation: Washington DC, USA
• [Presentation] The Study Group on New Liver Cancer Therapies (NLCT) in Japan. Efficacy and safety of miriplatin for hepatocellular carcinoma : a multi‐center retrospective study in Japan (2012)
  • Author(s): K Arai, S Kaneko, T Yamashita, K Ikeda, J Furuse, M Kudo
  • Organizer: AASLD 2012
  • Place of Presentation: Boston, USA
  • Year and Date: 2012-11-10
• [Presentation] A phase I study of vaccination with human telomerase reverse transcriptase-derived peptide in patients with hepatocellular carcinoma (2012)
  • Author(s): E Mizukoshi,T Yamashita, K Arai, H Sunagozaka, K Fushimi, S Kaneko
  • Organizer: AASLD2012
  • Place of Presentation: Boston, USA
  • Year and Date: 2012-11-10
• [Presentation] Efficacy and safety of hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma (2012)
  • Author(s): T Yamashita,T Terashima, K Arai, H Sunagozaka, E Mizukoshi, A Sakai, M Honda, S Kaneko
  • Organizer: AASLD2012
  • Place of Presentation: Boston, USA
  • Year and Date: 2012-11-09
• [Presentation] Efficacy and safety of miriplatin for hepatocellular carcinoma : a multi‐center retrospective study in Japan. (2012)
  • Author(s): Kuniaki Arai, Shuichi Kaneko, Tatsuya Yamashita, Kenji Ikeda, Junji Furuse, Masatoshi Kudo, The Study Group on New Liver Cancer Therapies (NLCT) in Japan.
  • Organizer: AASLD 2012
  • Place of Presentation: ハインズコンベンションセンター（米国）
• [Presentation] 肝細胞癌画像診断の進歩 肝細胞癌に対するSorafenib治療の効果判定基準比較 (2012)
  • Author(s): 荒井 邦明, 山下 竜也, 金子 周一
  • Organizer: 第48回日本肝臓学会総会
  • Place of Presentation: 石川県立音楽堂（石川県）
• [Presentation] MRIのTopics Gd-EOB-DTPA造影MRI肝細胞相低信号非多血性結節の長期経過に関する検討 (2012)
  • Author(s): 荒井 邦明, 山下 竜也, 金子 周一
  • Organizer: 第98回日本消化器病学会総会
  • Place of Presentation: 京王プラザホテル（東京都）
• [Presentation] 肝細胞癌に対するSorafenib治療の効果判定基準の比較 (2012)
  • Author(s): 荒井邦明, 山下竜也, 寺島健志，北原征明, 砂子阪肇, 金子周一
  • Organizer: 第6回日本肝がん分子標的治療研究会
  • Place of Presentation: ザ・プリンス箱根（神奈川県）
• [Presentation] 肝細胞癌に対するSorafenib治療の効果判定基準の比較 (2012)
  • Author(s): 荒井邦明, 山下竜也, 寺島健志，北原征明, 砂子阪肇, 金子周一
  • Organizer: 第48回日本肝癌研究会
  • Place of Presentation: 石川県立音楽堂（石川県）
• [Presentation] Efficacy and safety of hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma (2012)
  • Author(s): T. Yamashita, T. Terashima, K. Arai, H. Sunagozaka, T. Yamashita, E. Mizukoshi, A. Sakai, M. Honda, S. Kaneko
  • Organizer: AASLD 2012
  • Place of Presentation: ハインズコンベンションセンター（米国）
• [Presentation] A phase I study of vaccination with human telomerase reverse transcriptase-derived peptide in patients with hepatocellular carcinoma (2012)
  • Author(s): E. Mizukoshi, T. Yamashita, K. Arai, H. Sunagozaka, T. Yamashita, M. Honda, S. Kaneko,
  • Organizer: AASLD 2012
  • Place of Presentation: ハインズコンベンションセンター（米国）
• [Presentation] Impaired infiltration of immune regulatory cells into liver lobules of chronic hepatitis C patients with interferonresistant IL28B genotype (2012)
  • Author(s): M. Honda, A. Sakai, T. Shirasaki, M. Nakamura, T. Yamashita, K. Arai, T. Shimakami, Y. Sakai, T. Yamashita, E. Mizukoshi, S. Kaneko
  • Organizer: AASLD 2012
  • Place of Presentation: ハインズコンベンションセンター（米国）
• [Presentation] Increase of CD14+HLA-DR-/low myeloid-derived suppressor cells in hepatocellular carcinoma and its impact for prognosis of patients (2011)
  • Author(s): F Arihara,E Mizukoshi, M Kitahara, Y Takada, K Arai, T Yamashita, Y Nakamoto, S Kaneko
  • Organizer: AASLD2011
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-11-08
• [Presentation] Enhancement of tumor-associated antigen-specific T cell responses by radiofrequency ablation of hepatocellular carcinoma (2011)
  • Author(s): E Mizukoshi,F Arihara, T Yamashita, K Arai, H Sunagozaka, T Ueda, T Kagaya, T Yamashita, S Kaneko
  • Organizer: AASLD2011
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-11-08
• [Presentation] Distinct Liver Cancer Stem Cells defined by EpCAM and CD90 in Human Hepatocellular Carcinoma (2011)
  • Author(s): T Yamashita,M Honda, Y Nakamoto, E Mizukoshi, T Yamashita, K Arai, K Nio, Y Hara, X W.Wong, S Kaneko
  • Organizer: AASLD2011
  • Place of Presentation: San Francisco, USA
  • Year and Date: 2011-11-07
• [Presentation] Sonazoid造影超音波検査によるSorafenib治療効果ならびに副作用早期予測の試み (2011)
  • Author(s): 荒井邦明, 山下竜也, 北原征明, 砂子阪肇, 金子周一
  • Organizer: 第47回日本肝臓学会総会
  • Place of Presentation: ホテルグランパシフィック ル ダイバ（東京）
• [Presentation] 非典型的な造影パターンを呈した，造影超音波検査が診断に有用であった肝過形成結節の一例 (2011)
  • Author(s): 荒井邦明, 山下竜也, 高畠央，北原征明, 砂子阪肇, 金子周一
  • Organizer: 日本超音波医学会第31回中部地方会学術集会
  • Place of Presentation: 名古屋第一赤十字病院（名古屋）
• [Presentation] 造影超音波検査を用いたSorafenibの治療効果ならびに副作用早期予測の試み (2011)
  • Author(s): 荒井邦明, 山下竜也, 北原征明, 砂子阪肇, 金子周一
  • Organizer: 第47回日本肝癌研究会
  • Place of Presentation: 静岡県コンベンションアーツセンター（静岡）
• [Presentation] Gd-EOB-DTPA造影MRI肝細胞相にて低信号を呈する非多血性結節の経過 (2011)
  • Author(s): 荒井邦明, 山下竜也, 北原征明, 砂子阪肇, 金子周一
  • Organizer: 日本消化器病学会（JDDW2011）
  • Place of Presentation: マリンメッセ福岡(福岡）
• [Presentation] Gd-EOB-DTPA造影MRI肝細胞相低信号非多血性結節の自然経過に関する検討 (2011)
  • Author(s): 荒井邦明，山下竜也，北原征明，砂子阪肇，金子周一
  • Organizer: 第39回肝臓学会西部会
  • Place of Presentation: 岡山コンベンションセンター(岡山）
• [Book] 肝腫瘍, 臨床病態学 (2013)
  • Author(s): 荒井邦明,金子周一
  • Publisher: ヌーヴェルヒロカワ