Steatohepatitis as altered immune metabolism by Regulatory T cell
| Project/Area Number |
23790791
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Gastroenterology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
HAMAGUCHI Masahide 大阪大学, 免疫学フロンティア研究センター, 特任助教 (80350883)
|
|---|
| Project Period (FY) |
2011 – 2013
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2012: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2011: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
|---|
| Keywords | 非アルコール性脂肪肝炎 / 非アルコール性脂肪疾患 / 制御性T細胞 / 慢性炎症 / インスリン抵抗性 / レプチン抵抗性 / 非アルコール性脂肪肝疾患 / 消化器内科学 / 免疫学 / 自己免疫 / 自然炎症 / 脂肪肝 |
|---|
| Research Abstract |
Chronic inflammation is now considered to have a pivotal role in the metabolic abnormality. In liver, steatohepatitis has been recognized as the hallmarks of chronic inflammation. However, the mechanisms underlying the progression from simple steatosis to steatohepatitis have not clarified yet. Here, we showed that immune supressive activity by Treg cells were impaired under high leptin condition and steatohepatitis was observed under the condition of temporally liver regulatory T (Treg) cells depletion combined with high fat diet (HFD). Taken together, altered immune metabolism by Regulatory T cell due to leptin resistance in subjects with over nutrition or obesity could be a pathogen for the development of Steatohepatitis.
|
Report
(4 results)
Research Products
(25 results)
-
[Journal Article] An atlas of active enhancers across human cell types and tissues.2014
Author(s)
Anderson R, Gebhard C, Miguel-Escalada I, Hoof I, Bornholdt J, Boyd M, Chen Y, Zhao X, Schmidl C, Suzuki T, Collaborators(261) Enomoto H, etc.
-
Journal Title
Nature
Volume: 507
Issue: 7493
Pages: 455-461
DOI
Related Report
Peer Reviewed / Open Access
-
[Journal Article] A promoter-level mammalian expression atlas.2014
Author(s)
Forrest, A.R.R., Kawaji, H., Rehli, M., Baillie, J.K, de Hoon, M.J.L., Haberle, V., Lassmann, T., Kulakovskiy, I.V., Lizio, M., Itoh, M., Andersson, R., Mungall, C. J.,et al.
-
Journal Title
Nature
Volume: 507
Issue: 7493
Pages: 462-470
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
