Analysis of differentiation process from human ES/iPS cells into vascular cell components and researches using disease-specific iPS cells with vascular disorders
| Project/Area Number |
23790847
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Circulatory organs internal medicine
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | 幹細胞 / iPS細胞 / ES細胞 / 血管 / 再生医療 / 血管内皮細胞 / 血管平滑筋細胞 / 血管生物学 |
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| Research Abstract |
We clarified the transition of the expression of humoral factors and their receptors in the differentiation process from human ES/iPS cells to vascular cell components.We induced vascular endothelial cells and mural cells from patient-specific iPS cells of inherited vascular disorders, and compared these cells with those of healthy volunteers.In some diseases, we succeeded in detecting a diagnostic marker and showing the significance of a susceptibility gene mutation in vascular cell dysfunction.
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Report
(3 results)
Research Products
(30 results)
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[Journal Article] Human induced pluripotent stem cells differentiated into chondrogenic lineage via generation of mesenchymal progenitor cells2013
Author(s)
Koyama, N., Miura, M., Nakao, K., Kondo, E., Fujii, T., Taura, D., Kanamoto, N., Sone, M., Yasoda, A., Arai, H., Bessho, K., Nakao, K.
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Journal Title
Stem Cells and Development
Volume: 22(1)
Issue: 1
Pages: 102-113
DOI
Related Report
Peer Reviewed
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[Journal Article] A case of myelolipoma with bilateral adrenal hyperaldosteronism cured after unilateral adrenalectomy2012
Author(s)
Inuzuka M, Tamura N, Sone M, Taura D, Sonoyama T, Honda K, Kojima K, Fukuda Y, Ueda Y, Yamashita Y, Kondo E, Yamada G, Fujii T, Miura M, Kanamoto N, Yasoda A, Arai H, Mikami Y, Sasano H, Nakao K.
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Journal Title
Intern Med
Volume: 51(5)
Pages: 479-85
NAID
Related Report
Peer Reviewed
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[Journal Article] Induced pluripotent stem cells generated from diabetic patients with mitochondrial DNA A3243G mutation.2012
Author(s)
Fujikura J, Nakao K, Sone M, Noguchi M, Mori E, Naito M, Taura D, Harada-Shiba M, Kishimoto I, Watanabe A, Asaka I, Hosoda K, Nakao K.
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Journal Title
Diabetologia
Volume: in press
Related Report
Peer Reviewed
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[Journal Article] Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma2011
Author(s)
Sonoyama T, Sone M, Miyashita K, Tamura N, Yamahara K, Park K, Oyamada N, Taura D, Inuzuka M, Kojima K, Honda K, Fukunaga Y, Kanamoto N, Miura M, Yasoda A, Arai H, Itoh H, Nakao K
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Journal Title
J Clin Endocrinol Metab
Volume: 96(9)
Issue: 9
Pages: 2771-8
DOI
Related Report
Peer Reviewed
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[Journal Article] Significance of adrenocorticotropin stimulation test in the diagnosis of an aldosterone-producing adenoma.2011
Author(s)
Sonoyama T, Sone M, Miyashita K, Tamura N, Yamahara K, Park K, Oyamada N, Taura D, Inuzuka M, Kojima K, Honda K, Fukunaga Y, Kanamoto N, Miura M, Yasoda A, Arai H, Itoh H, Nakao K.
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Journal Title
J Clin Endocrinol Metab.
Volume: 96(9)
Pages: 2771-8
Related Report
Peer Reviewed
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