The Role of Smooth Muscle Rac1 in Neointimal Formation after Vascular Injury
Project/Area Number |
23790883
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Circulatory organs internal medicine
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Research Institution | Nihon University |
Principal Investigator |
LI YUXIN 日本大学, 医学部, 助教 (30599048)
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Project Period (FY) |
2011 – 2012
|
Project Status |
Completed (Fiscal Year 2013)
|
Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | 分子血管病態学 / 血管障害 / 新生内膜 / 低分子量Gタンパク質 / Rac1 / 血管平滑筋細胞 |
Research Abstract |
Four weeks after carotid artery ligation, neointimal formation in smRac1+/- mice was substantially reduced compared to control mice. SmRac1+/- SMCs showed decreased chemotaxis, proliferation with decreased phosphorylation of PAK1, ERK, and reduced ROS production compared to that of control SMCs. Furthermore, the expression of cell cycle-associated genes, such as CyclineA, CyclineE, and CDK4 decreased in SMCs from smRac1+/- mice than that in control mice. Moreover, the expression of SM22, a differentiation marker of smooth muscle and highly expressed in differentiated phenotypes of SMCs, was increased in smRac1+/- mice than that in control mice. These results indicate that SMC Rac1 mediates vessel remodeling after intimal injury through inhibition of SMC migration, proliferation and differentiation. Therapeutic modalities, which target Rac1 in SMCs, therefore, may be beneficial in preventing vascular proliferative diseases.
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Report
(4 results)
Research Products
(25 results)
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[Journal Article] Plaque stabilization by intensive LDL-cholesterol lowering therapy with atorvastatin is delayed in type 2 diabetic patients with coronary artery disease-Serial angioscopic and intravascular ultrasound analysis2013
Author(s)
T. Takayama, T. Hiro, Y. Ueda, J. Honye, S. Komatsu, O. Yamaguchi, Y. Li, J. Yajima, K. Takazawa, S. Nanto, S. Saito , A. Hirayama and K. Kodama
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Journal Title
J. Cardiol
Volume: 61
Issue: 6
Pages: 381-386
DOI
Related Report
Peer Reviewed
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[Journal Article] Influence of Achieved Low-Density Lipoprotein Cholesterol Level With Atorvastatin Therapy on Stabilization of Coronary Plaques2012
Author(s)
Okada K, Ueda Y, Takayama T, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Takazawa K, Nanto S, Saito S, Hirayama A, Kodama K
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Journal Title
Circ J
Volume: 76
Pages: 1197-202
URL
Related Report
Peer Reviewed
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[Journal Article] Influence of Achieved Low-Density Lipoprotein Cholesterol Level With Atorvastatin Therapy on Stabilization of Coronary Plaques2012
Author(s)
Okada K, Ueda Y, Takayama T, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Takazawa K, Nanto S, Saito S, Hirayama A, Kodama K.
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Journal Title
Circulation Journal
Volume: 76
Issue: 5
Pages: 1197-1202
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Journal Article] Plaque-Stabilizing Effect of Atorvastatin Is Stronger for Plaques Evaluated as More Unstable by Angioscopy and Intravenous Ultrasound2011
Author(s)
Hirayama A, Saito S, Ueda Y, Takayama T, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Nanto S, Takazawa K, Kodama K
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Journal Title
Circ J
Volume: 75(6)
Pages: 1448-54
URL
Related Report
Peer Reviewed
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[Journal Article] Notch1 in Bone Marrow–Derived Cells Mediates Cardiac Repair After Myocardial Infarction2011
Author(s)
Li Y, Hiroi Y, Ngoy S, Okamoto R, Noma K, Wang CY, Wang HW, Zhou Q, Radtke F, Liao R, Liao JK
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Journal Title
Circulation
Volume: 123
Issue: 8
Pages: 866-76
DOI
Related Report
Peer Reviewed
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[Journal Article] Plaque-Stabilizing Effect of Atorvastatin Is Stronger for Plaques Evaluated as More Unstable by Angioscopy and Intravenous Ultrasound2011
Author(s)
Hirayama A, Saito S, Ueda Y, Takayama T, Honye J, Komatsu S, Yamaguchi O, Li Y, Yajima J, Nanto S, Takazawa K, Kodama K.
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Journal Title
Circulation Journal
Volume: 75
Issue: 6
Pages: 1448-1454
DOI
NAID
ISSN
1346-9843, 1347-4820
Related Report
Peer Reviewed
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[Presentation] Pleiotropic Effects Of Statin In Stabilization Of Unstable Coronary Plaque - Direct Evidence From Low Density Lipoprotein Receptor Knockout Pig2013
Author(s)
Yuxin Li, Akira Onishi, Mitsumasa Sudo, Seiji Fukushima, Qingfei Lin, Shunichi Suzuki, Daiichiro Fuchimoto, Shoichiro Sembon, Masaki Iwamoto, Michiko Hashimoto, Hironori Haruta, Tadateru Takayama, Satoshi Kunimoto, Takafumi Hiro, Taro Matsumoto, Masako Mitsumata, Masahiko Sugitani, Satoshi Saito, Atsushi Hirayama
Organizer
Scientific Sessions 2013 of American Heart Association.
Place of Presentation
Dallas, Texas
Related Report
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[Presentation] Development of Hypercholesterolemia-Induced Complex Unstable Atherosclerotic Lesions in a Novel Low Density Lipoprotein Receptor Knockout Pig2012
Author(s)
Sudo M, Li Y,Onishi A, Fukushima S, Suzuki S, Fuchimoto D, Sembon S, Iwamato M, Hashimoto M, Haruta H, Takayama T, Hiro T, Matsumoto T, Mitsumata M, Sugitani M, Saito S, Hirayama A.
Organizer
Scientific Sessions 2012 of American Heart Association
Place of Presentation
Los Angeles
Related Report
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