| Project/Area Number |
23790915
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Sapporo Medical University |
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Principal Investigator |
KURONUMA Koji 札幌医科大学, 医学部, 助教 (40563250)
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| Project Period (FY) |
2011 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / 間質性肺炎 / 肺サーファクタント / 非感染性肺障害 / ブレオマイシン肺障害モデル / ブレオマイシン / Toll様受容体 |
|---|
| Research Abstract |
Since non-infectious pulmonary disorders can progress to a fatal clinical condition due to excessive production of inflammatory cytokine, the purpose of this study is to understand the lung protective role of pulmonary surfactant protein A (SP-A). SP-A deficient mice demonstrated the low survival rate, the increase of cell count in bronchoalveolar lavage fluid, and the production of proinflammatory cytokine following the transairway administration of bleomycin. SP-A might control innate immune systemby binding to bleomycin strongly and directly, and inhibiting bleomycin from binding to toll-like receptor.
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