Pulmonary surfactant protein A modulates non-infectious lung injury.

• Project/Area Number: 23790915
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Sapporo Medical University
• Principal Investigator: KURONUMA Koji 札幌医科大学, 医学部, 助教 (40563250)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / 間質性肺炎 / 肺サーファクタント / 非感染性肺障害 / ブレオマイシン肺障害モデル / ブレオマイシン / Toll様受容体

Research Abstract

Since non-infectious pulmonary disorders can progress to a fatal clinical condition due to excessive production of inflammatory cytokine, the purpose of this study is to understand the lung protective role of pulmonary surfactant protein A (SP-A). SP-A deficient mice demonstrated the low survival rate, the increase of cell count in bronchoalveolar lavage fluid, and the production of proinflammatory cytokine following the transairway administration of bleomycin. SP-A might control innate immune systemby binding to bleomycin strongly and directly, and inhibiting bleomycin from binding to toll-like receptor.

Research Products

• [Journal Article] Pulmonary surfactant protein A protectslung epithelium from cytotoxicity of humanβ-defensin 3 (2012)
  • Author(s): Saito A, Ariki S, Sohma H, Nishitani C, Inoue K, Ebata N, Takahashi M, Hasegawa Y, Kuronuma K, Takahashi H, Kuroki Y
  • Journal Title: J Biol Chem Volume: 287(18) Pages: 15034-43
  • Peer Reviewed
• [Journal Article] Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 3. (2012)
  • Author(s): Saito H, Kuronuma K, et.al.
  • Journal Title: Journal of Biological Chemistry Volume: 印刷中
  • Peer Reviewed
• [Presentation] The decrease of surfactant protein D in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia. (2012)
  • Author(s): Nishikiori H, Chiba H, Otsuka M, Kuronuma K, Takahashi H
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: Vienna, Austria
• [Presentation] ブレオマイシン誘導肺障害に対するSP-Aの自然免疫制御作用 (2012)
  • Author(s): 黒沼幸治、工藤和実、黒木由夫、高橋弘毅
  • Organizer: 日本呼吸器学会総会
  • Place of Presentation: 神戸
• [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構 (2011)
  • Author(s): 黒沼幸治、工藤和実、黒木由夫、高橋弘毅
  • Organizer: 日本肺サーファクタント界面医学会総会
  • Place of Presentation: 徳島
• [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構 (2011)
  • Author(s): 黒沼幸治、工藤和実、黒木由夫、高橋 弘毅
  • Organizer: 日本呼吸器学会総会
• [Presentation] ブレオマイシン誘導肺障害に対するSP-Aの自然免疫制御作用
  • Author(s): 黒沼幸治
  • Organizer: 日本呼吸器学会総会
  • Place of Presentation: 神戸市
• [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構
  • Author(s): 黒沼 幸治
  • Organizer: 日本肺サーファクタント・界面医学会第４７回学術研究会
  • Place of Presentation: 徳島大学医学部青藍会館