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Pulmonary surfactant protein A modulates non-infectious lung injury.

Research Project

Project/Area Number 23790915
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionSapporo Medical University

Principal Investigator

KURONUMA Koji  札幌医科大学, 医学部, 助教 (40563250)

Project Period (FY) 2011 – 2012
Project Status Completed (Fiscal Year 2012)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2011: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords非閉塞性肺疾患癌 / 肺線維症 / 呼吸器感染症 / 間質性肺炎 / 肺サーファクタント / 非感染性肺障害 / ブレオマイシン肺障害モデル / ブレオマイシン / Toll様受容体
Research Abstract

Since non-infectious pulmonary disorders can progress to a fatal clinical condition due to excessive production of inflammatory cytokine, the purpose of this study is to understand the lung protective role of pulmonary surfactant protein A (SP-A). SP-A deficient mice demonstrated the low survival rate, the increase of cell count in bronchoalveolar lavage fluid, and the production of proinflammatory cytokine following the transairway administration of bleomycin. SP-A might control innate immune systemby binding to bleomycin strongly and directly, and inhibiting bleomycin from binding to toll-like receptor.

Report

(3 results)
  • 2012 Annual Research Report   Final Research Report ( PDF )
  • 2011 Research-status Report
  • Research Products

    (8 results)

All 2012 2011 Other

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (6 results)

  • [Journal Article] Pulmonary surfactant protein A protectslung epithelium from cytotoxicity of humanβ-defensin 32012

    • Author(s)
      Saito A, Ariki S, Sohma H, Nishitani C, Inoue K, Ebata N, Takahashi M, Hasegawa Y, Kuronuma K, Takahashi H, Kuroki Y
    • Journal Title

      J Biol Chem

      Volume: 287(18) Pages: 15034-43

    • Related Report
      2012 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pulmonary surfactant protein A protects lung epithelium from cytotoxicity of human β-defensin 3.2012

    • Author(s)
      Saito H, Kuronuma K, et.al.
    • Journal Title

      Journal of Biological Chemistry

      Volume: 印刷中

    • Related Report
      2011 Research-status Report
    • Peer Reviewed
  • [Presentation] The decrease of surfactant protein D in bronchoalveolar lavage fluid in patients with idiopathic pulmonary fibrosis and nonspecific interstitial pneumonia.2012

    • Author(s)
      Nishikiori H, Chiba H, Otsuka M, Kuronuma K, Takahashi H
    • Organizer
      European Respiratory Society Annual Congress
    • Place of Presentation
      Vienna, Austria
    • Related Report
      2012 Final Research Report
  • [Presentation] ブレオマイシン誘導肺障害に対するSP-Aの自然免疫制御作用2012

    • Author(s)
      黒沼幸治、工藤和実、黒木由夫、高橋弘毅
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      神戸
    • Related Report
      2012 Final Research Report
  • [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構2011

    • Author(s)
      黒沼幸治、工藤和実、黒木由夫、高橋弘毅
    • Organizer
      日本肺サーファクタント界面医学会総会
    • Place of Presentation
      徳島
    • Related Report
      2012 Final Research Report
  • [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構2011

    • Author(s)
      黒沼幸治、工藤和実、黒木由夫、高橋 弘毅
    • Organizer
      日本呼吸器学会総会
    • Related Report
      2012 Final Research Report
  • [Presentation] ブレオマイシン誘導肺障害に対するSP-Aの自然免疫制御作用

    • Author(s)
      黒沼幸治
    • Organizer
      日本呼吸器学会総会
    • Place of Presentation
      神戸市
    • Related Report
      2012 Annual Research Report
  • [Presentation] SP-AによるTLR2を介したブレオマイシン誘導肺障害の制御機構

    • Author(s)
      黒沼 幸治
    • Organizer
      日本肺サーファクタント・界面医学会第47回学術研究会
    • Place of Presentation
      徳島大学医学部青藍会館
    • Related Report
      2011 Research-status Report

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Published: 2011-08-05   Modified: 2019-07-29  

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