The role of nuclear hormone receptor PPARδon the pathogenesis of diabetic nephropathy

• Project/Area Number: 23790942
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Okayama University
• Principal Investigator: OGAWA Daisuke 岡山大学, 大学院・医歯薬学総合研究科, 准教授 (70535195)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2012: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 糖尿病性腎症 / 核内受容体

Research Abstract

Activation of the nuclear hormone receptor peroxisome proliferator-activated receptor o(PPARo) has been shown to improve insulin resistance, adiposity, and plasma HDL levels. Recently, several studies reported that activation of PPARδis atheroprotective, however, the effect for the renalfunction remains unclear. Here we report the renoprotecitve effects of PPARo activation in a model of streptozotosin-induced diabetic nephropathy.

Research Products

• [Journal Article] Combination therapy with an angiotensin converting enzyme inhibitor and an angiotensin II receptor antagonist ameliorates microinflammation and oxidative stress in patients with diabetic nephropathy (2013)
  • Author(s): Nakamura A, Shikata K, Nakatou T, KitamuraT, KajitaniN, OgawaD, Makino H
  • Journal Title: J Diabetes Invest Volume: 4 Pages: 195-201
  • Peer Reviewed
• [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing oxidative stress in db/db mice (2013)
  • Author(s): Sato-Horiguchi C, Ogawa D, Wada J, Tachibana H, Kodera R, Eguchi J, Nakatsuka A, Terami N, Shikata K, Makino H
  • Journal Title: Nephron Exp Nephrol Volume: 121
  • Peer Reviewed
• [Journal Article] The effects of telmisartan treatment on the abdominal fat depot in patients with metabolic syndrome and essential hypertension: Abdominal fat Depot Intervention Program of Okayama (ADIPO) (2013)
  • Author(s): Murakami K, Wada J, Ogawa D, Horiguchi CS, Miyoshi T, Sasaki M, Uchida HA, Nakamura Y, Makino H
  • Journal Title: Diab Vasc Dis Res Volume: 10 Pages: 93-6
  • Peer Reviewed
• [Journal Article] Telmisartan attenuates diabetic nephropathy by suppressing ixidative stress in db/db mice. (2013)
  • Author(s): Sato-Horiguchi C
  • Journal Title: Nephron Exp Nephrol Volume: 121(3-4) Issue: 3-4 Pages: 97-108
  • DOI: 10.1159/000343102
  • Peer Reviewed
• [Journal Article] Liver x receptor agonist suppresses osteopontin expression in diabetic nephropathy (2012)
  • Author(s): Tachibana H, Ogawa D, Matsushita Y, Bruemmer D, Wada J, Teshibawara S, Eguchi J, Uchida HA, Shikata K, Makino H
  • Journal Title: J Am Soc Nephrol Volume: 23 Pages: 1835-46
  • Peer Reviewed
• [Journal Article] Vaspin is an adipokine ameliorating ER Stress in obesity as a ligand for cell-surface GRP78/MTJ-1 complex (2012)
  • Author(s): Nakatsuka A, Wada J, Iseda I, Teshigawara S, Higashio K, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Hida K, Eguchi J, Horiguchi CS, Ogawa D, Matsuki Y, Hiramatsu R, Yagita H, Kakuta S, Iwakura Y, Makino H
  • Journal Title: Diabetes Volume: 61 Pages: 2823-2832
  • NAID: 120005300245
  • Peer Reviewed
• [Journal Article] A case of emphysematous cholecystitis in the patient with type 2 diabetes mellitus associated with schizophrenia (2012)
  • Author(s): Ogawa A, Shikata K, Uchida HA, Shinoura S, Yokomichi N, Ogawa D, Sato-Horiguchi C, Yagi T, Wada J, Makino H
  • Journal Title: J Diabetes Invest Volume: 3 Pages: 534-535
  • Peer Reviewed
• [Journal Article] Phenotypic change of macrophages in the progression of diabetic nephropathy; sialoadhesin-positive activated macrophages are increased in diabetic kidney (2012)
  • Author(s): Nagase R, Kajitani N, Shikata K, Ogawa D, Kodera R, Okada S, Kido Y, Makino H
  • Journal Title: Clin Exp Nephrol Volume: 16 Pages: 739-748
  • NAID: 10031122261
  • Peer Reviewed
• [Journal Article] Cholecystokinin plays a novel protective role in diabetic kidney through anti-inflammatory actions on macrophage: anti-inflammatory effect of cholecystokinin (2012)
  • Author(s): Miyamoto S, Shikata K, Miyasaka K, Okada S, Sasaki M, Kodera R, Hirota D, Kajitani N, Takatsuka T, Kataoka HU, Nishishita S, Sato C, Funakoshi A, Nishimori H, Uchida HA, Ogawa D, Makino H
  • Journal Title: Diabetes Volume: 61 Pages: 897-907
  • Peer Reviewed
• [Journal Article] RXR antagonism induces G0/G1 cell cycle arrest and ameliorates obesity by up-regulating the p53-p21 (Clip1) pathway in adipocytes (2012)
  • Author(s): Nakatsuka A, Wada J, Hida K, Hida A, Eguchi J, Teshigawara S, Murakami K, Kanzaki M, Inoue K, Terami T, Katayama A, Ogawa D, Kagechika H, Makino H
  • Journal Title: J Pathol Volume: 226 Pages: 784-95
  • Peer Reviewed
• [Journal Article] Activation of liver x receptor inhibits osteopontin and ameliorates diabetic nephropathy. (2012)
  • Author(s): Tachibana H
  • Journal Title: J Am Soc Nephrol Volume: 23(11) Issue: 11 Pages: 1835-1846
  • DOI: 10.1681/asn.2012010022
  • Peer Reviewed
• [Journal Article] High glucose increases metallothionein expression in renal proximal tubular epithelial cells (2011)
  • Author(s): Ogawa D, Asanuma M, Miyazaki I, Tachibana H, Wada J, Sogawa N, Sugaya T, Kitamura S, Maeshima Y, Shikata K, Makino H
  • Journal Title: Exp Diabetes Res2011 Volume: 2011 Pages: 534872-534872
  • Peer Reviewed
• [Journal Article] The macrophage is a key factor in renal injuries caused by glomerular hyperfiltration (2011)
  • Author(s): Sasaki M, Shikata K, Okada S, Miyamoto S, Nishishita S, Usui HK, Sato C, Wada J, Ogawa D, Makino H
  • Journal Title: Acta Med Okayama Volume: 65 Pages: 81-9
  • NAID: 120002970764
  • Peer Reviewed
• [Journal Article] Intercellular adhesion molecule-1 plays a critical role for glomeruloscrelosis after subtotal nephrectomy (2011)
  • Author(s): Kido Y, Ogawa D, Shikata K, Sasaki M,Nagase R, Okada S, Usui-Kataoka H, Wada J, Makino H
  • Journal Title: Clin Exp Nephrol Volume: 15 Pages: 212-9
  • Peer Reviewed
• [Journal Article] Activation of peroxisome proliferator-activated receptor δ inhibits streptozotocin-induced diabetic nephropathy through anti-inflammatory mechanisms in mice. (2011)
  • Author(s): Matsushita Y, Ogawa D, Wada J, Noriko Y, Shikata K, Sato C, Tachibana H, Toyota N, Makino H
  • Journal Title: Diabetes Volume: 60 Pages: 960-968
  • Peer Reviewed
• [Presentation] 早期糖尿病性腎症におけるTelmisartanの抗酸化作用の検討 (2012)
  • Author(s): 佐藤千景、小川大輔、松下裕一、橘洋美、小寺亮、廣田大昌、宮本聡、梶谷展生、和田淳、四方賢一、槇野博史
  • Organizer: 第55回日本糖尿病学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-17
• [Presentation] 早期糖尿病性腎症におけるTelmisartanの抗酸化作用の検討 (2012)
  • Author(s): 堀口千景、小川大輔、橘洋美、松下裕一、小寺亮、廣田大昌、梶谷展生、片岡仁美、和田淳、四方賢一、槇野博史
  • Organizer: 第27回日本糖尿病合併症学会
  • Place of Presentation: 福岡
• [Presentation] 糖尿病性腎症におけるPPARδアゴニストの腎保護効果 (2011)
  • Author(s): 小川大輔、松下裕一、四方賢一、和田淳、佐藤千景、橘洋美、豊田智子、槇野博史
  • Organizer: 第54回日本腎臓学会学術総会
  • Place of Presentation: 横浜
  • Year and Date: 2011-06-16
• [Presentation] PPARoアゴニストは抗炎症効果により糖尿病性腎症の進展を抑制する (2011)
  • Author(s): 松下裕一、小川大輔、橘洋美、豊田智子、佐藤千景、和田淳、四方賢一、槇野博史
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
  • Year and Date: 2011-05-19
• [Presentation] PPARδアゴニストは抗炎症効果により糖尿病性腎症の進展を抑制する (2011)
  • Author(s): 松下裕一、小川大輔、橘洋美、豊田智子、佐藤千景、和田淳、四方賢一、槇野博史
  • Organizer: 第54回日本糖尿病学会年次学術集会
  • Place of Presentation: 札幌
• [Presentation] 核内受容体制御による糖尿病性腎症治療の可能性 (2011)
  • Author(s): 小川大輔
  • Organizer: 第26回日本糖尿病合併症学会
  • Place of Presentation: 大宮
• [Presentation] 心腎連関における炎症の役割とその制御 (2011)
  • Author(s): 小川大輔
  • Organizer: 第23回日本糖尿病性腎症研究会
  • Place of Presentation: 東京
• [Book] 日本臨床増刊 最新臨床糖尿病学 下 (2012)
  • Author(s): 小川大輔,槇野博史
  • Publisher: 日本臨床社
• [Book] 糖尿病腎症のすべて (2012)
  • Author(s): 小川大輔
  • Publisher: 中山書店
• [Book] 糖尿病×CKD診療ガイドQ&A (2012)
  • Author(s): 小川大輔
  • Publisher: 南山堂
• [Book] 日本臨床増刊 最新臨床糖尿病学 下 (2012)
  • Author(s): 小川大輔，槇野博史
  • Publisher: 日本臨床社
• [Book] 糖尿病診療ガイド (2011)
  • Author(s): 小川大輔，槇野博史
  • Publisher: 南山堂
• [Book] 高血圧ナビゲーター第3版 (2011)
  • Author(s): 小川大輔，槇野博史
  • Publisher: メディカルビュー社