Expression of SHP-1 in the membrane of red blood cells in renal anemia

• Project/Area Number: 23790944
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Okayama University
• Principal Investigator: AKAGI Shigeru 岡山大学, 岡山大学病院, 講師 (80509315)
• Project Period (FY): 2011 – 2012
• Project Status: Completed (Fiscal Year 2012)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000); Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: SHP-1 / 腎性貧血 / 赤血球膜 / spectrin

Research Abstract

To elucidate mechanism of renal anemia in chronic renal failure, the expression of Src Homology-2 containing hematopoietic phosphatase-1 (SHP-1) and protein in the RBC membrane was examined in renal anemia model mice (5/6 nephrectomy). The expression of spectrin, one of the composition of RBC membrane was comfirmed and SHP-1 was also detected. However, no significant difference was observed in the expression of spectrin or SHP-1 between 5/6 nephrctomy model and control mice.