Analyses for transport of Amyloid beta through the blood-brain barrier
| Project/Area Number |
23790994
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Yamaguchi University |
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Principal Investigator |
SANO Yasuteru 山口大学, 医学(系)研究科(研究院), 助教 (20379978)
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| Project Period (FY) |
2011 – 2013
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | アミロイドβ / 血液脳関門 / アルツハイマー病 / Aβ蛋白 / Ａβ蛋白 |
|---|
| Research Abstract |
The clearance of amyloid beta (Ab) from the brain could be a novel therapeutic target for Alzheimer disease. We examined the role of efflux transporters as well as LRP1 on Ab transport on human BBB. Our results using a new human in vitro blood-brain barrier (BBB) model suggest that ABCG2 as well as LRP1 act to prevent the blood-borne Ab from entering brain at the human BBB. In addition, we also elucidated that rifampicin up-regulates the expression of LRP1 and ABCG2 in endothelial cells derived from human BBB.
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Report
(4 results)
Research Products
(32 results)
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[Journal Article] Blood-brain barrier destruction determines Fischer/Bickerstaff clinical phenotypes: an in vitro study2013
Author(s)
Kazuyuki Saito, Fumitaka Shimizu, Michiaki Koga, Yasuteru Sano, Ayako Tasaki, Masa-aki Abe, Hiroyo Haruki, Toshihiko Maeda, S. Suzuki, Susumu Kusunoki, Hidehiro Mizusawa, Takashi Kanda.
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Journal Title
J Neurol Neurosurg Psychiatry
Volume: 84
Issue: 7
Pages: 756-765
DOI
Related Report
Peer Reviewed
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[Journal Article] Sequential changes in the non-coding control region sequences of JC polyomaviruses from the cerebrospinal fluid of patients with progressive multifocal leukoencephalopathy.2013
Author(s)
Nakamichi K, Kishida S, Tanaka K, Suganuma A, Sano Y, Sano H, Kanda T, Maeda N, Kira JI, Itoh A, Kato N, Tomimoto H, Kurane I, Lim CK, Mizusawa H, Saijo M
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Journal Title
Archives of Virology
Volume: 158
Issue: 3
Pages: 639-650
DOI
Related Report
Peer Reviewed
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[Journal Article] Establishment and characterization of human peripheral nerve microvascular endothelial cell lines : a new in vitro blood-nerve barrier (BNB) model2012
Author(s)
Abe M, Sano Y, Maeda T, Shimizu F, Kashiwamura Y, Haruki H, Saito K, Tasaki A, Kawai M, Terasaki T, Kanda T
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Journal Title
Cell Struct Funct
Volume: 37(2)
Pages: 89-100
NAID
URL
Related Report
Peer Reviewed
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[Journal Article] p.Arg332Cys mutation of NOTCH3 gene in two unrelated Japanese families with CADASIL2011
Author(s)
Sano Y, Shimizu F, Kawai M, Omoto M, Negoro K, Kurokawa T, Fujisawa H, Suzuki M, Okayama N, Suehiro Y, Hinoda Y, Kanda T
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Journal Title
Intern Med
Volume: 50(22)
Pages: 2833-8
NAID
URL
Related Report
Peer Reviewed
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